Review: COVID 19 as a natural experiment in physiology: developments in physical chemistry throw light on its anomalous features. — R0/PR4

Published: Jan. 6, 2022

Chapter 1: COVID-19 pathogenesis poses paradoxes difficult to explain with traditional physiology. For instance, since type II pneumocytes are considered the primary cellular target of SARS-CoV-2; as these produce pulmonary surfactant (PS), possibility that insufficient PS plays a role in has been raised. However, opposite predicted high alveolar surface tension is found many early patients: paradoxically normal lung volumes and compliance occur, profound hypoxemia. That ‘COVID anomaly’ was quickly rationalised by invoking vascular mechanisms–mainly because surprisingly preserved hypoxemic cases. quick rejection damage only occurred actual mechanism gas exchange long presumed be non-problematic, due diffusion through surface. On contrary, we provide physical chemical evidence occurs an process expansion contraction three-dimensional structures its associated proteins. This view explains anomalous observations from level cryo-TEM whole individuals. It encompasses results premature infants deepest diving seals. Once understood, COVID anomaly dissolves straightforwardly explained covert viral 3D structure PS, direct treatment implications. As natural experiment, SARS-CoV-2 virus itself helped us simplify clarify not nature dyspnea relationship compliance, but also fine detail including such features water channels which had heretofore entirely unexpected.

Language: Английский

Review: COVID 19 as a natural experiment in physiology: developments in physical chemistry throw light on its anomalous features. — R0/PR2

Published: Dec. 19, 2021

Chapter 1: COVID-19 pathogenesis poses paradoxes difficult to explain with traditional physiology. For instance, since type II pneumocytes are considered the primary cellular target of SARS-CoV-2; as these produce pulmonary surfactant (PS), possibility that insufficient PS plays a role in has been raised. However, opposite predicted high alveolar surface tension is found many early patients: paradoxically normal lung volumes and compliance occur, profound hypoxemia. That ‘COVID anomaly’ was quickly rationalised by invoking vascular mechanisms–mainly because surprisingly preserved hypoxemic cases. quick rejection damage only occurred actual mechanism gas exchange long presumed be non-problematic, due diffusion through surface. On contrary, we provide physical chemical evidence occurs an process expansion contraction three-dimensional structures its associated proteins. This view explains anomalous observations from level cryo-TEM whole individuals. It encompasses results premature infants deepest diving seals. Once understood, COVID anomaly dissolves straightforwardly explained covert viral 3D structure PS, direct treatment implications. As natural experiment, SARS-CoV-2 virus itself helped us simplify clarify not nature dyspnea relationship compliance, but also fine detail including such features water channels which had heretofore entirely unexpected.

Language: Английский