Injury From Nematode Lung Migration Induces an IL‐13‐Dependent Hyaluronan Matrix DOI Creative Commons
Rebecca J. Dodd,

D.J. Moffatt,

Monika Vachiteva

et al.

Proteoglycan Research, Journal Year: 2024, Volume and Issue: 2(4)

Published: Oct. 1, 2024

ABSTRACT A consistent feature of lung injury is a rapid and sustained accumulation hyaluronan (HA). The rodent gut‐dwelling nematode Nippostrongylus brasiliensis (Nb) induces tissue damage as it migrates through the lungs. Type 2 immune responses are essential for repair lungs, hence Nb infection well‐established model to study immune‐mediated repair. We found that was associated with increased HA in lung, which peaked at d7 post‐infection (p.i.). Deposition alveolar epithelium correlated regions damaged type response, characterized by eosinophilia cytokines such IL‐13. Consistent HA, we observed expression major synthase Has2 , alongside decreased Hyal1, Hyal2 Tmem2 can degrade existing HA. Expression Tsg6 also presence inter‐α‐inhibitor heavy chain–HA complexes (HC·HA) p.i. Using IL‐13‐deficient mice, during IL‐13 dependent. Our data thus provide further evidence modulator matrix challenge links IL‐13‐mediated regulation pathways.

Language: Английский

Age-related immune response disparities between adults and children with severe COVID-19: a case–control study in China DOI Creative Commons
Hongliang Chen, Yuan Li, Liping Yuan

et al.

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 4, 2025

Background Elucidation of immune response differences is critical for uncovering underlying mechanisms and developing potential intervention measures among adults children with COVID-19. Methods In this retrospective study, we analyzed serum biochemical markers cytokine profiles COVID-19 in the First People’s Hospital Chenzhou Hunan, China from 1 December 2022 to 13 February 2023. A case–control study was conducted using propensity score matching (PSM) mitigate possible confounding factors. Results The significant observed included lymphocyte exhaustion, an increased neutrophil-to-lymphocyte (NEU/LYM) ratio, high levels C-reactive protein (CRP), a storm, characterized by Th1 proinflammatory cytokines, including interleukin 1β (IL-1β), IL-6, IL-8, interferon type I (IFN- γ ), tumor necrosis factor (TNF- α ) lung severe adult patients. Additionally, systemic responses were Conclusion Significant between highlight different

Language: Английский

Citations

0
Hyaluronan in COVID-19: a matrix for understanding lung disease DOI Creative Commons
Rebecca J. Dodd, Judith E. Allen, Anthony J. Day

et al.

mBio, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 18, 2024

The polysaccharide hyaluronan (HA) is an important component of lung extracellular matrix that increases following infection with influenza or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Hellman et al. (U. Hellman, E. Rosendal, J. Lehrstrand, Henriksson, al., mBio 15:e01303-24, https://doi.org/10.1128/mbio.01303-24) show fragmented HA accumulates in the lungs disease 2019 (COVID-19) patients, systemic levels being associated reduced function 3-6 months after infection. This study provides novel insights into HA's role COVID-19 pathology and its potential utility as a biomarker for severity. However, much remains to be understood about how it compares other conditions. In particular, HA-binding proteins organizing crosslinked network yet fully determined at molecular level. knowledge crucial understanding inter-relationships between structure regulation immune response, thus our ability target therapeutically improved outcomes COVID-19.

Language: Английский

Citations

2
Injury From Nematode Lung Migration Induces an IL‐13‐Dependent Hyaluronan Matrix DOI Creative Commons
Rebecca J. Dodd,

D.J. Moffatt,

Monika Vachiteva

et al.

Proteoglycan Research, Journal Year: 2024, Volume and Issue: 2(4)

Published: Oct. 1, 2024

ABSTRACT A consistent feature of lung injury is a rapid and sustained accumulation hyaluronan (HA). The rodent gut‐dwelling nematode Nippostrongylus brasiliensis (Nb) induces tissue damage as it migrates through the lungs. Type 2 immune responses are essential for repair lungs, hence Nb infection well‐established model to study immune‐mediated repair. We found that was associated with increased HA in lung, which peaked at d7 post‐infection (p.i.). Deposition alveolar epithelium correlated regions damaged type response, characterized by eosinophilia cytokines such IL‐13. Consistent HA, we observed expression major synthase Has2 , alongside decreased Hyal1, Hyal2 Tmem2 can degrade existing HA. Expression Tsg6 also presence inter‐α‐inhibitor heavy chain–HA complexes (HC·HA) p.i. Using IL‐13‐deficient mice, during IL‐13 dependent. Our data thus provide further evidence modulator matrix challenge links IL‐13‐mediated regulation pathways.

Language: Английский

Citations

2