The avengers: SAMHD1 cooperates with MX2/MxB to defend against HIV-1 DOI Creative Commons
Zhi Wan,

Gang Zhong,

Huiqing Wang

et al.

mBio, Journal Year: 2024, Volume and Issue: 15(10)

Published: Sept. 6, 2024

SAMHD1 is an intrinsic limiting factor that effectively prevents HIV-1 infection in macrophages, dendritic cells, and resting CD4+ T cells. Extensive studies have underscored the indispensable role of dNTPase activity its antiviral function by primarily depleting dNTPs quiescent thereby impeding cDNA synthesis. However, recent advancements understanding posttranslational modifications revealed specific modification site mutants maintain their ability to reduce dNTP levels while impairing inhibition replication. Thus, precise anti-HIV-1 mechanism remains enigmatic, necessitating a comprehensive underlying mechanisms develop novel therapeutic strategies targeting activity. Recent findings Guo et al. shed light on as core sensor suppressing after viral synthesis through interaction with MX2 (H. Guo, W. Yang, H. Li, J. al., mBio 15:e01363-24, 2024, https://doi.org/10.1128/mbio.01363-24).

Language: Английский

Sodium propionate protects against bronchopulmonary dysplasia by inhibiting IL-17-mediated apoptosis of alveolar epithelial cells DOI Creative Commons
Anni Xie, Weilin Qian, Danni Ye

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 5, 2025

Sodium propionate (SP) has been shown to enhance alveolar growth retardation in Bronchopulmonary Dysplasia (BPD), but the mechanism remains unclear. The aim of this study is explore potential SP treatment BPD by utilizing animal and cell models along with bioinformation analysis. Neonatal mice were exposed either air (21% O2) or hyperoxia (85% from first day after birth establish model. neonatal intraperitoneally injected normal saline (control group) (500 mg/kg, 8 14. significantly reduced inflammatory condition septal thickening, decreased fusion mitigated weight loss mice. ELISA results demonstrated that inhibited secretion IL-17, IL-6 TNFα. Transcriptome analysis confirmed IL-17 signaling pathway closely related therapeutic effects on BPD. In addition, MX2, MMP10, IL-11, ZMAT4 SEC1 genes identified as key targets involved treating Meanwhile, mouse epithelial cells, apoptosis was induced hyperoxia, it following intervention. expression genes: IL-17A, IL-6, TNFα cox2 treated cells conclusion, through transcriptome analysis, experiments, we explored role sodium attenuating a model pathway.

Language: Английский

Citations

0
dNTP depletion and beyond: the multifaceted nature of SAMHD1-mediated viral restriction DOI Creative Commons
Pak‐Hin Hinson Cheung, Hua Yang, Li Wu

et al.

Journal of Virology, Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

ABSTRACT SAMHD1 is a dNTPase of mammalian cells. In 2011, was found to be host restriction factor against retroviruses through dNTP reduction. Recent research provides evidence that the antiviral mechanisms cannot explained solely by its activity. Instead, versatility SAMHD1-mediated various viruses suggests extend beyond depletion. This explains multifaceted and broad functions play significant role in innate immunity.

Language: Английский

Citations

0
CRL4-DCAF1 Ubiquitin Ligase Dependent Functions of HIV Viral Protein R and Viral Protein X DOI Creative Commons

Ashley Dobransky,

Mary Root,

Nicholas Hafner

et al.

Viruses, Journal Year: 2024, Volume and Issue: 16(8), P. 1313 - 1313

Published: Aug. 17, 2024

The Human Immunodeficiency Virus (HIV) encodes several proteins that contort the host cell environment to promote viral replication and spread. This is often accomplished through hijacking of cellular ubiquitin ligases. These reprogrammed complexes initiate or enhance ubiquitination may otherwise act restrain replication. Ubiquitination target alter protein function proteasome-dependent destruction. HIV Viral Protein R (Vpr) related HIV-2 X (Vpx), engage CRL4-DCAF1 ligase complex numerous proteins. In this review we describe its interactions with Vpr Vpx. We additionally summarize targeted by association as well observed hypothesized impact on HIV.

Language: Английский

Citations

2
The avengers: SAMHD1 cooperates with MX2/MxB to defend against HIV-1 DOI Creative Commons
Zhi Wan,

Gang Zhong,

Huiqing Wang

et al.

mBio, Journal Year: 2024, Volume and Issue: 15(10)

Published: Sept. 6, 2024

SAMHD1 is an intrinsic limiting factor that effectively prevents HIV-1 infection in macrophages, dendritic cells, and resting CD4+ T cells. Extensive studies have underscored the indispensable role of dNTPase activity its antiviral function by primarily depleting dNTPs quiescent thereby impeding cDNA synthesis. However, recent advancements understanding posttranslational modifications revealed specific modification site mutants maintain their ability to reduce dNTP levels while impairing inhibition replication. Thus, precise anti-HIV-1 mechanism remains enigmatic, necessitating a comprehensive underlying mechanisms develop novel therapeutic strategies targeting activity. Recent findings Guo et al. shed light on as core sensor suppressing after viral synthesis through interaction with MX2 (H. Guo, W. Yang, H. Li, J. al., mBio 15:e01363-24, 2024, https://doi.org/10.1128/mbio.01363-24).

Language: Английский

Citations

1