Wastewater-based surveillance of respiratory viruses in Northern Tuscany (Italy): Challenges and added value for public health purposes DOI Creative Commons
Annalaura Carducci, Ileana Federigi, Alessandra Almeida Castro Pagani

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 957, P. 177752 - 177752

Published: Nov. 30, 2024

During the COVID-19 pandemic, wastewater-based surveillance (WBS) showed great potential as an early warning system and could complement human clinical surveillance. This study aimed to highlight added value of WBS for respiratory infections alongside different systems. Sewage collected at entry four Wastewater Treatment Plants in Northern Tuscany (Italy) were analyzed SARS-CoV-2, Human Adenovirus (HAdV), Respiratory Syncytial Virus (RSV) Influenza (IV), over two years. Clinical data available area, while other viruses came from national virological For correlation was highly significant between hospitalization (ρ = 0.8460), but not wastewater or 0.1682 ρ 0.0569, respectively). SARS-CoV-2 RNA found even period when cases reported, indicating a continuous community circulation. HAdVs detected 74.3 % samples, most sequences identified belonged enteric species (HAdV-F41), need distinguishing causing diseases RSV only winter 2022-2023, IV had been wastewater, probably due poor test sensitivity. In conclusion, although there may be various challenges testing targets, can provide pathogen-specific situational assessment which complements existing

Language: Английский

Recreational response patterns by sociodemographic groups in a pandemic DOI
W. Jason Beasley, Alyssa S. Thomas, Matthew R. Sloggy

et al.

Leisure/Loisir, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 22

Published: Sept. 16, 2024

Language: Английский

Citations

0
A Serum Multi-Parametric Analysis Identifies an Early Innate Immune Signature Associated to Increased Vaccine-Specific Antibody Production and Seroconversion in Simultaneous COVID-19 mRNA and Cell-Based Quadrivalent Influenza Vaccination DOI Creative Commons
Martina Severa, Daniela Ricci, Marilena P. Etna

et al.

Vaccines, Journal Year: 2024, Volume and Issue: 12(9), P. 1050 - 1050

Published: Sept. 13, 2024

In this pilot study, a multi-parametric analysis comparing immune responses in sera of adult healthy subjects (HS) or people with type 2 diabetes mellitus (T2D) undergoing the single simultaneous administration mRNA-based COVID-19 and cellular quadrivalent inactivated influenza vaccines was conducted. While SARS-CoV-2 antibodies remains comparable, antibody titers seroconversion were significantly higher upon vaccination. Magnitude anti-influenza humoral response closely correlated an early innate signature, previously described for vaccine, composed IL-15, IL-6, TNF-α, IFN-γ, CXCL-10 here extended also to acute-phase protein Pentraxin 3. People T2D receiving vaccination showed protective comparable HS correlating induction IFN-γ/CXCL10 significant reduction circulating glucose level due increased oxidation digestion consumption. These data, although preliminary in-need validation larger cohorts, might be exploited optimize future chronic disorders, including diabetes.

Language: Английский

Citations

0
NDICATORS OF BLOOD COAGULATION FUNCTION, CONCENTRATION OF ENDOTHELIN-1 AND LONG-COVID DOI Creative Commons
Vladyslav Svitailo, Mykola Dmytrovych Chemych

Bulletin of Problems Biology and Medicine, Journal Year: 2024, Volume and Issue: 1(3), P. 180 - 180

Published: Jan. 1, 2024

Language: Английский

Citations

0
Optimal Annual COVID-19 Vaccine Boosting Dates Following Previous Booster Vaccination or Breakthrough Infection DOI Creative Commons
Jeffrey P. Townsend, Hayley B. Hassler, Alex Dornburg

et al.

Clinical Infectious Diseases, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 26, 2024

COVID-19 booster vaccinations mitigate transmission and reduce the morbidity mortality associated with infection. However, optimal date for administration remains uncertain. Geographic variation in infection rates throughout year makes it challenging to intuit best yearly effectively prevent infection, also provide guidance on how alter response a breakthrough

Language: Английский

Citations

0
Wastewater-based surveillance of respiratory viruses in Northern Tuscany (Italy): Challenges and added value for public health purposes DOI Creative Commons
Annalaura Carducci, Ileana Federigi, Alessandra Almeida Castro Pagani

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 957, P. 177752 - 177752

Published: Nov. 30, 2024

During the COVID-19 pandemic, wastewater-based surveillance (WBS) showed great potential as an early warning system and could complement human clinical surveillance. This study aimed to highlight added value of WBS for respiratory infections alongside different systems. Sewage collected at entry four Wastewater Treatment Plants in Northern Tuscany (Italy) were analyzed SARS-CoV-2, Human Adenovirus (HAdV), Respiratory Syncytial Virus (RSV) Influenza (IV), over two years. Clinical data available area, while other viruses came from national virological For correlation was highly significant between hospitalization (ρ = 0.8460), but not wastewater or 0.1682 ρ 0.0569, respectively). SARS-CoV-2 RNA found even period when cases reported, indicating a continuous community circulation. HAdVs detected 74.3 % samples, most sequences identified belonged enteric species (HAdV-F41), need distinguishing causing diseases RSV only winter 2022-2023, IV had been wastewater, probably due poor test sensitivity. In conclusion, although there may be various challenges testing targets, can provide pathogen-specific situational assessment which complements existing

Language: Английский

Citations

0