The Effect of Alcohol Consumption on Progressive Supranuclear Palsy: A Cross‐Sectional Study DOI Creative Commons
敏彦 平田, Bohan Zhang,

Heyin Liu

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(12)

Published: Dec. 1, 2024

ABSTRACT Aims To investigate the effect of alcohol consumption on clinical symptoms in a cohort Progressive supranuclear palsy (PSP) patients. Methods We conducted cross‐sectional study focusing possible and probable PSP patients Qilu Hospital Shandong University. Diagnoses phenotypes were confirmed using 2017 Movement Disorder Society criteria Multiple Allocations eXtinction (MAX) rules. Data drinking habits demographics collected via face‐to‐face interviews medical records reviews. Clinical scales assessed motor nonmotor symptoms. Alcohol was categorized into light, moderate, heavy status. Using multivariate linear regression adjusting for confounding factors, we analyzed relationship between Results The comprised 128 participants (59.4% male 45.31% drinkers). has been associated with severe symptoms, particularly among Compared nondrinkers, consumers exhibit significantly more cognitive impairments, domains visuospatial executive abilities, memory, language. Moreover, when categorizing individuals based their intake weekly, those show higher Rating Scale (PSPRS) Unified Parkinson's Disease (UPDRS) scores, as well lower Montreal Cognitive Assessment (MoCA) Mini Mental State Examination (MMSE) scores compared to nonconsumers. Conclusion Our findings indicate an association pronounced PSP, especially function. It raises possibility that may play role modulating course PSP.

Language: Английский

Gut mycobiome and neuropsychiatric disorders: insights and therapeutic potential DOI Creative Commons
Inès Hadrich, M. Turki, I. Chaâri

et al.

Frontiers in Cellular Neuroscience, Journal Year: 2025, Volume and Issue: 18

Published: Jan. 8, 2025

The human gut mycobiome, a minor but integral component of the microbiome, has emerged as significant player in host homeostasis and disease development. While bacteria have traditionally been focus microbiome studies, recent evidence suggests that fungal communities (mycobiota) may also play crucial role modulating health, particularly neuropsychiatric disorders. This review aims to provide comprehensive overview current knowledge on relationship between mycobiome disorders, exploring potential targeting novel therapeutic strategy. We summarized findings from metagenomic analyses characterize diversity composition mycobiota discuss how these interact with other microorganisms via gut-brain axis. Key methodologies for studying mycobiota, such high-throughout sequencing bioinformatics approaches, were reviewed highlight advances field. Emerging research links dysbiosis conditions schizophrenia, Alzheimer's disease, autism spectrum bipolar disorder, depression. Studies indicate specific populations, Candida Saccharomyces, influence neuroinflammation, permeability immune responses, thereby affecting mental health outcomes. Understanding mycobiome's disorders opens new avenues interventions, including antifungal treatments, probiotics, dietary modifications. Future should integrate multi-omics approaches unravel complex interkingdom interactions within ecosystem, paving way personalized medicine care.

Language: Английский

Citations

3
Neurolaw: Revisiting Huberty v. McDonald’s through the Lens of Nutritional Criminology and Food Crime DOI Creative Commons

Alan Logan,

Jeffrey J. Nicholson,

Stephen J. Schoenthaler

et al.

Laws, Journal Year: 2024, Volume and Issue: 13(2), P. 17 - 17

Published: March 21, 2024

Recent studies have illuminated the potential harms associated with ultra-processed foods, including poor mental health, aggression, and antisocial behavior. At same time, human gut microbiome has emerged as an important contributor to cognition behavior, disrupting concepts of biopsychosocial ‘self’ raising questions related free will. Since is undeniably connected dietary patterns components, topics nutrition microbes are heightened interest neuroscience psychiatry. Research spanning epidemiology, mechanistic bench science, intervention trials brought legitimacy nutritional criminology idea that relevance criminal justice system. The individual community-level relationships between behavior also salient torts relatively new field food crime—that which examines vast harms, grand-scale non-communicable diseases behavioral outcomes, caused by manufacturers, distributors, marketers products. Here in this essay, we will synthesize various strands research, reflecting emergent using a notable case straddled both neurolaw crime, Huberty v. McDonald’s (1987). It our contention legalome—microbiome omics science applied forensics—will play increasing role 21st-century courtroom discourse, policy, decision-making.

Language: Английский

Citations

7
Therapeutic potential of faecal microbiota transplantation for alcohol use disorder, a narrative synthesis DOI

JOHN M. DOCHERTY

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown, P. 111354 - 111354

Published: April 1, 2025

Language: Английский

Citations

0
The role of gut flora-driven Th cell responses in preclinical rheumatoid arthritis DOI
Shih‐Yao Chen, Dan Liu, Xiang Li

et al.

Journal of Autoimmunity, Journal Year: 2025, Volume and Issue: 154, P. 103426 - 103426

Published: April 28, 2025

Language: Английский

Citations

0
The Intersection of Ultra-Processed Foods, Neuropsychiatric Disorders, and Neurolaw: Implications for Criminal Justice DOI Creative Commons
Susan L. Prescott, Kathleen F. Holton, Christopher A. Lowry

et al.

NeuroSci, Journal Year: 2024, Volume and Issue: 5(3), P. 354 - 377

Published: Sept. 23, 2024

Over the last decade there has been increasing interest in links between consumption of ultra-processed foods and various neuropsychiatric disorders, aggression, antisocial behavior. Neurolaw is an interdisciplinary field that seeks to translate rapid voluminous advances brain science into legal decisions policy. An enhanced understanding biophysiological mechanisms by which influence behavior allows for a historical reexamination one forensic neuropsychiatry's most famous cases-

Language: Английский

Citations

3
Prenatal Stress and Ethanol Exposure: Microbiota-Induced Immune Dysregulation and Psychiatric Risks DOI Open Access
Rosana Camarini, Priscila Marianno, Maylin Hanampa-Maquera

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 9776 - 9776

Published: Sept. 10, 2024

Changes in maternal gut microbiota due to stress and/or ethanol exposure can have lasting effects on offspring’s health, particularly regarding immunity, inflammation response, and susceptibility psychiatric disorders. The literature search for this review was conducted using PubMed Scopus, employing keywords phrases related stress, exposure, microbiota, microbiome, gut–brain axis, diet, dysbiosis, progesterone, placenta, prenatal development, inflammation, depression identify relevant studies both preclinical human research. Only a limited number of reviews were included support the arguments. encompassed from 1990s present. This begins by exploring role modulating host health disease. It then examines how disturbances affect immune system. analysis continues investigating interplay between focusing influences offspring its implications depression. also considers impact consumption with an emphasis microbiota. Finally, it is suggested that dysbiosis may be significantly exacerbated combined leading system dysfunction chronic which could increase risk offspring. These interactions underscore potential novel mental interventions address especially relation health.

Language: Английский

Citations

2
Homicide or Happiness: Did Folate Fortification and Public Health Campaigns Influence Homicide Rates and the Great American Crime Decline? DOI Creative Commons
Stephen J. Schoenthaler, Susan L. Prescott,

Alan Logan

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(7), P. 1075 - 1075

Published: April 6, 2024

The last several years have witnessed a remarkable growth in research directed at nutrition and behavior, with increased interest the field of nutritional criminology. It is becoming clear that dietary patterns specific nutrients play an important role cognition including those related to aggression, violence, antisocial activity. Included this expanding knowledge base recognition folate, through multiple pathways, enzymatic reactions gut microbiome ecology, plays critical central nervous system functioning. These mechanistic advances allow for retrospective analysis topic remains unexplained—the sudden unpredicted drop homicide other violent crime rates United States nations 1990s. Here, we revisit marked reduction lens coincident public health campaign (and subsequent mandatory fortification) increase folic acid intake. Based on objectively measured blood folate levels National Health Nutrition Examination Surveys, there little doubt tissue dramatic rise national level from 1988 2000. Drawing accumulated emerging neurobehavioral aspects it our contention relatively massive may contributed reductions States.

Language: Английский

Citations

1
The mechanisms of protective effect of a peptide from Pinctada martensii meat against alcohol-induced liver injury in mice DOI Creative Commons
Yifan Chen, Jie Zhou, Xiaoyang Liu

et al.

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 122, P. 106481 - 106481

Published: Sept. 29, 2024

Language: Английский

Citations

1
Mapping the relationship between alcohol use disorder and gut microbiota: a 20-year bibliometric study DOI Creative Commons
Xiang Ao, Yonglong Chang, Shi Li

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 18, 2024

Background Alcohol use disorder (AUD) is a psychiatric that widespread worldwide. significant contributor to the global burden of death, disability and disease. Modulation gut microbiota promising approach improve efficacy minimize adverse effects colorectal cancer treatment. The relationship between presence microbes AUD has been widely validated. However, few studies have examined this using bibliometric methods. Therefore, study analyzes research hotspots trends in human microbiology over last two decades from perspective. This aims at provide new directions for basic clinical field. Objective A comprehensive discussion current state intestinal flora. Methods We collected publications Web Science Core Collection database 2003 2023 according established inclusion criteria. analyzed countries, institutions, authors, contributions CiteSpace, VOSviewer, Scimago Graphics visualize Results total 2,102 were obtained, with rapid increase number since 2016. United States China are major contributors field network partners several countries. Five hundred ninety-five academic journals published articles on topic. author highest Prof. Bernd Schnabl Department Gastroenterology University California, San Diego. In addition “gut flora” “AUD,” high frequency words keyword co-occurrence analysis included alcoholic liver disease, tryptophan metabolism, enterohepatic axis, fecal microbial transplantation. Conclusion results visualization key areas past 20 years. suggest role its potential mechanisms, especially therapeutic targets, should be closely monitored could become hot topic

Language: Английский

Citations

1
Intestinal Microbiota and Alcohol Addiction DOI Open Access

Ridha Khélifa,

M. Rabhia

SAR Journal of Pathology and Microbiology, Journal Year: 2024, Volume and Issue: 5(03), P. 54 - 58

Published: May 14, 2024

The involvement of the gut microbiota in various diseases, including psychiatric disorders, is increasingly being studied. We present here a review recent data regarding potential role development and maintenance alcohol addiction. Changes composition function have been observed alcoholic patients. Several pathophysiological mechanisms explain this addiction, through intestinal immune system, production psychoactive bacterial metabolites, or alteration permeability. Modulation nutritional pharmaceutical interventions thus promising therapeutic avenue for management alcoholism.

Language: Английский

Citations

0