РЕАКТИВАЦІЯ ХРОНІЧНОГО ЛАЙМ-БОРЕЛІОЗУ ПІСЛЯ ПЕРЕНЕСЕНОЇ ІНФЕКЦІЇ COVID-19: КЛІНІЧНИЙ ВИПАДОК

Здобутки клінічної і експериментальної медицини, Journal Year: 2024, Volume and Issue: 1, P. 81 - 88

Published: March 28, 2024

РЕЗЮМЕ. Враховуючи зростаючу актуальність комбінованого перебігу інфекційних захворювань розглянуто клінічний випадок реактивації хронічного Лайм-бореліозу після COVID-19. Мета роботи – підтвердити потенційний вплив коронавірусної хвороби на можливість хронічної інфекційної патології, навіть за умови легкого COVID-19 прикладі клінічного випадку Лайм-бореліозу. Матеріал і методи. При дослідженні застосовані клініко-анамнестичні, епідеміологічні, лабораторні (загальноклінічні, та інструментальні (електрокардіографія, Холтерівське моніторування, рентгенологічне) обстеження. Результати. Був встановлений діагноз бореліозного поліартриту, а результатами лабораторного інструментального обстеження Лайм-міокардиту. У ході подальшого пошуку потенційного збудника, який призвів до виявлених змін, хворий протестований виявлення антитіл Bоrrelia burgdorferi методом імуноферментного аналізу. Отриманий позитивний результат при детекції специфічних (IgM 46,64 ОД/мл, IgG 87,31 ОД/мл) вказував реактивацію Лайм-бореліозу. Призначено лікування: доксициклін 100 мг × 2 рази/добу 28 днів, протизапальна терапія. Після завершення курсу етіотропної терапії клінічна ремісія, також негативні результати IgM через 3, 6 12 місяців. Висновок. На клінічному показані труднощі встановлення діагнозу Лайм-бореліозу, наголошено необхідності клінічної настороженості фахівців практичної охорони здоров’я щодо подібних випадків, COVID-19.

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"The Expanding Spectrum of Ixodes Tick-Borne Diseases: Insights, Challenges, and Innovations"

Annals of Reviews & Research, Journal Year: 2024, Volume and Issue: 11(2)

Published: June 8, 2024

Annals of Reviews & Research open access journal that publishes high-quality solicited and unsolicited articles, from various types subject areas ranging management to engineering sciences, accounting, criminal etc. which deal with innovative research work.

Language: Английский

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Borrelia burgdorferi loses essential genetic elements and cell proliferative potential during stationary phase in culture but not in the tick vector.

Published: Oct. 28, 2024

The Lyme disease agent

Language: Английский

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High-Throughput Drug Screening on Borrelia Garinii and Borrelia Afzelii Identified Hypocrellin A as an Active Drug Candidate against Borrelia Species

Published: Dec. 8, 2022

Lyme disease (LD) is a tick-transmitted infection caused by Borrelia burgdorferi sensu lato species which includes B. burgdorferi, afzelii, and garinii. The majority of patients with early LD can be cured standard treatment, yet some still suffer from post-treatment syndrome (PTLDS). presence persisters has been proposed as contributing factor, cannnot completely killed the currently used antibiotics for disease. Finding new pharmaceuticals targeting crucial in developing more effective treatment. Here, we first confirmed existence cultures garinii afzelii then conducted high-throughput screening custom drug library against persister-rich stationary-phase afzelii. Among 2427 compounds screened, hypocrellin A (HA), anthracycline class drugs, topical along other natural were identified to have strong potential killing HA was most active anti-Borrelia compound, capable eradicating persisters, particular when combined doxycycline and/or ceftriaxone. Liposoluble antioxidant vitamin E found antagonize activity HA, indicating HA’s target cell membrane where HA-triggered reactive oxygen (ROS) generation took place light. distinct bactericidal but had poor or no Gram-positive Gram-negative bacteria. Identification above-mentioned candidates may help develop therapies LD.

Language: Английский

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Homology Modeling and Molecular Docking Studies of Selected Substituted Tetradecane on vlsE Borrelia spielmanii

Journal of Molecular Docking, Journal Year: 2022, Volume and Issue: 2(1), P. 16 - 28

Published: June 30, 2022

VlsE is the key enzyme in antibacterial and suicide antigenic variation. While vlsE of Borrelia burgdorferi sensu lato complex causes Lyme disease. Therefore, considered a significant drug target for In this paper, we report model three-dimensional structure resulting from homology modeling study. Homology was developed using three different software evaluating best model. Subsequent docking studies natural substrate tetradecane known drugs were performed with SwissDock shed new light on binding characteristics enzyme. Binding energies ranged -2024.12 to -2032.17 kcal/mol. As result, they might be synthesized further into active commercial drugs.

Language: Английский

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High-Throughput Drug Screening on Borrelia garinii and Borrelia afzelii Identified Hypocrellin A as an Active Drug Candidate Against Borrelia Species

Infectious Microbes & Diseases, Journal Year: 2023, Volume and Issue: 5(2), P. 83 - 92

Published: March 7, 2023

Abstract Lyme disease (LD) is a tick-transmitted infection caused by Borrelia burgdorferi sensu lato species, which include B . , afzelii and garinii The majority of patients with early LD can be cured the standard treatment, yet some still suffer from posttreatment syndrome. presence persisters has been proposed as contributing factor, because they cannot completely eradicated currently used antibiotics for LD. Finding new pharmaceuticals targeting crucial developing more effective treatments. Here, we first confirmed existence in cultures then conducted high-throughput screening custom drug library against persister-rich stationary-phase cultures. Among 2427 compounds screened, hypocrellin A (HA), anthracycline class drugs topical along other natural were identified to have strong potential killing HA was most active anti- compound, capable eradicating persisters, particular when combined doxycycline and/or ceftriaxone. Liposoluble antioxidant vitamin E found antagonize activity HA, indicating HA’s target cell membrane where triggers generation reactive oxygen species light. distinct bactericidal but had poor or no gram-positive gram-negative bacteria. Identification abovementioned candidates may help develop therapies

Language: Английский

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Borrelia Burgdorferi Sensu Lato Infection-induced Autoimmunity – A Decennary Literature Review

Journal of Health Study and Medicine, Journal Year: 2023, Volume and Issue: 2023(1), P. 59 - 71

Published: Jan. 1, 2023

Abstract Borrelia burgdorferi sensu lato is a Gram-negative spirochete that causes Lyme disease (Lyme borreliosis). The signs and symptoms of are consequence the immune response to in soft tissues, it debated if said can become an autoimmune body over time due bacterial HLA/MHC molecular mimicry. Continual Disease (CDL) also known as Post-Treatment Syndrome (PTLDS) broad group rapidly appearing flu-rash cognitive difficulties combined with chronic fatigue observed after at least six months completing treatment. This review contains scientific collections throughout last 10 years studies related alleged post-infection auto-immunogenicity.

Language: Английский

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Renegade Bacterial Genetic Sequences in a Stealth Adapted Virus: Biological and Diagnostic Implications

Authorea (Authorea), Journal Year: 2022, Volume and Issue: unknown

Published: July 14, 2022

There are major differences between viruses, bacteria, and eukaryotic cells in the structuring of their genomes, modes replication, capacity to horizontally transfer genetic sequences.DNA sequencing studies on a virus cultured from patient with chronic fatigue syndrome (CFS) have confirmed previously underappreciated certain viruses capture bacterial cellular sequences as part infectious process.The originated an African green monkey simian cytomegalovirus (SCMV).It is termed stealth adapted since infection not accompanied by inflammation.The immune evasion attributed loss mutation genes coding for relatively few components that normally targeted system.This article further elucidation origins many bacterial-derived present virus.There multiple clones close but non-identical sequence alignments different genomic regions Ochrobactrum quorumnocens A44 species bacteria.Another set matched most closely diverse Mycoplasma fermentans bacteria.The several other could only be approximately aligned those types clone 3B513 consistent contributions genomes term viteria refers bacteria-derived sequences.They likely primary cause CFS autism, act cofactors illnesses, including AIDS.As more general phenomenon renegade can lead mistaken diagnoses rather than viral diseases.It important genetically additional patients wide range currently being Mycoplasma, Borrelia, or Streptococcal infections.

Language: Английский

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Reply to Luger, “Why Is It So Hard to Find Persistent Borreliella burgdorferi?”

mBio, Journal Year: 2022, Volume and Issue: 13(5)

Published: Aug. 22, 2022

Language: Английский

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Why Is It So Hard to Find Persistent Borreliella burgdorferi?

mBio, Journal Year: 2022, Volume and Issue: 13(5)

Published: Aug. 22, 2022

Language: Английский

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