The roles of ferroptosis in cancer: Tumor suppression, tumor microenvironment, and therapeutic interventions

Cancer Cell, Journal Year: 2024, Volume and Issue: 42(4), P. 513 - 534

Published: April 1, 2024

Language: Английский

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From imbalance to impairment: the central role of reactive oxygen species in oxidative stress-induced disorders and therapeutic exploration

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 18, 2023

Increased production and buildup of reactive oxygen species (ROS) can lead to various health issues, including metabolic problems, cancers, neurological conditions. Our bodies counteract ROS with biological antioxidants such as SOD, CAT, GPx, which help prevent cellular damage. However, if there is an imbalance between these antioxidants, it result in oxidative stress. This cause genetic epigenetic changes at the molecular level. review delves into how plays a role disorders caused by We also look animal models used for researching pathways. study offers insights mechanism, pathology, changes, assist drug development disease understanding.

Language: Английский

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Thioredoxin Reductase Inhibition for Cancer Therapy

The Annual Review of Pharmacology and Toxicology, Journal Year: 2021, Volume and Issue: 62(1), P. 177 - 196

Published: Aug. 24, 2021

The cytosolic selenoprotein thioredoxin reductase 1 (TrxR1, TXNRD1), and to some extent mitochondrial TrxR2 (TXNRD2), can be inhibited by a wide range of electrophilic compounds. Many such compounds also yield cytotoxicity toward cancer cells in culture or mouse models, most are likely irreversibly modify the easily accessible selenocysteine residue TrxR1, thereby inhibiting its normal activity reduce (Trx1, TXN) other substrates enzyme. This leads an oxidative challenge. In cases, forms TrxR1 not catalytically inert instead converted prooxidant NADPH oxidases, named SecTRAPs, thus further aggravating stress, particularly expressing higher levels this review, possible molecular cellular consequences these effects discussed relation therapy, with focus on outstanding questions that should addressed if targeted inhibition is developed for therapeutic use.

Language: Английский

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Bone marrow stromal cell‐derived exosomal circular RNA improves diabetic foot ulcer wound healing by activating the nuclear factor erythroid 2‐related factor 2 pathway and inhibiting ferroptosis

Diabetic Medicine, Journal Year: 2022, Volume and Issue: 40(7)

Published: Dec. 20, 2022

Abstract Background Diabetic foot ulcer (DFU) remains a serious chronic diabetic complication that can lead to disability. CircRNA‐itchy E3 ubiquitin protein ligase (circ‐ITCH) was observed be down‐regulated in retinopathy and nephropathy, overexpression of circ‐ITCH could inhibit the processes these diseases. However, detailed physiological pathological functions wound healing DFU remain undetermined. Methods Exosomes derived from bone marrow stromal cells (BMSCs) were isolated identified. Cell viability angiogenesis human umbilical vein endothelial (HUVECs) evaluated by cell counting kit‐8 (CCK‐8) tube formation assays, respectively. The interplays circ‐ITCH, TATA‐Box‐binding associated factor 15 (TAF15) nuclear erythroid 2‐related 2 (Nrf2) mRNA analysed RNA immunoprecipitation (RIP), fluorescence situ hybridization (FISH) combined immunofluorescent staining pull‐down assays. qRT‐PCR, western blot or immunohistochemistry (IHC) used measure expression TAF15, Nrf2, vascular growth (VEGFR) ferroptosis‐related makers. mice model established verify vitro results. Results Circ‐ITCH vivo models DFU. Deferoxamine (DFO), an iron chelating agent, improved angiogenic ability high glucose (HG)‐treated HUVECs. Overexpression co‐cultured with exosomal BMSCs alleviate HG‐induced ferroptosis improve HUVECs recruited TAF15 stabilize Nrf2 mRNA, thus activating signalling pathway suppressing ferroptosis. Exosomal also accelerated process inhibiting time‐dependent manner. Conclusion inhibited through activation recruiting protein, ultimately accelerating

Language: Английский

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Oxidative stress and the role of redox signalling in chronic kidney disease

Nature Reviews Nephrology, Journal Year: 2023, Volume and Issue: 20(2), P. 101 - 119

Published: Oct. 19, 2023

Language: Английский

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