Maternal and Fetal Outcomes of COVID-19 According to the Trimester of Diagnosis: A Cross-Sectional Prospective Study in a Tertiary University Hospital DOI Open Access
Naser Al-Husban,

Rahaf Mohammad Di’bas,

Sara Salem Karadsheh

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(17), P. 5262 - 5262

Published: Sept. 5, 2024

Pregnant women are considered a high-risk group because they may be particularly susceptible to COVID-19. Our study tried relate fetomaternal outcomes and trimester-specific infection.

Language: Английский

An update on COVID-19 and pregnancy DOI Open Access
Denise J. Jamieson, Sonja A. Rasmussen

American Journal of Obstetrics and Gynecology, Journal Year: 2021, Volume and Issue: 226(2), P. 177 - 186

Published: Sept. 14, 2021

Language: Английский

Citations

421
SARS-CoV-2 infection during pregnancy and risk of preeclampsia: a systematic review and meta-analysis DOI Creative Commons

Agustín Conde‐Agudelo,

Roberto Romero

American Journal of Obstetrics and Gynecology, Journal Year: 2021, Volume and Issue: 226(1), P. 68 - 89.e3

Published: July 21, 2021

To examine the relationship between SARS-CoV-2 infection during pregnancy and risk for preeclampsia.

Language: Английский

Citations

248
COVID-19 in pregnancy: implications for fetal brain development DOI Creative Commons
Lydia L. Shook, Elinor L. Sullivan, Jamie O. Lo

et al.

Trends in Molecular Medicine, Journal Year: 2022, Volume and Issue: 28(4), P. 319 - 330

Published: Feb. 14, 2022

The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during pregnancy on the developing fetal brain is poorly understood. Other antenatal infections such as influenza have been associated with adverse neurodevelopmental outcomes in offspring. Although vertical transmission has rarely observed SARS-CoV-2 to date, given potential for profound maternal immune activation (MIA), likely. Here we review evidence that and other viral can result maternal, placental, activation, ultimately offspring morbidity. Finally, highlight need cellular models development better understand short- long-term impacts next generation.

Language: Английский

Citations

119
Inflammatory responses in the placenta upon SARS-CoV-2 infection late in pregnancy DOI Creative Commons
Lissenya B. Argueta, Lauretta A. Lacko, Yaron Bram

et al.

iScience, Journal Year: 2022, Volume and Issue: 25(5), P. 104223 - 104223

Published: April 11, 2022

The effect of SARS-CoV-2 infection on placental function is not well understood. Analysis placentas from women who tested positive at delivery showed genomic and subgenomic RNA in 22 out 52 placentas. Placentas two mothers with symptomatic COVID-19 whose pregnancies resulted adverse outcomes for the fetuses contained high levels viral Alpha variant RNA. was localized to trophoblasts that cover fetal chorionic villi direct contact maternal blood. intervillous spaces were infiltrated macrophages T cells. Transcriptome analysis an increased expression chemokines pathways associated inflammation. Infection cultures live spike protein-pseudotyped lentivirus syncytiotrophoblast and, rare cases, endothelial cells mediated by ACE2 Neuropilin-1. Viruses Alpha, Beta, Delta spikes infected significantly greater levels.

Language: Английский

Citations

78
Fetal Deaths in Ireland Due to SARS-CoV-2 Placentitis Caused by SARS-CoV-2 Alpha DOI Open Access
Brendan Fitzgerald, Keelin O’Donoghue,

Noel McEntagart

et al.

Archives of Pathology & Laboratory Medicine, Journal Year: 2022, Volume and Issue: 146(5), P. 529 - 537

Published: Jan. 12, 2022

A severe third wave of COVID-19 disease affected Ireland in the first 3 months 2021. In this wave, 1 second-trimester miscarriage and 6 stillbirths were observed Irish population because placental insufficiency as a result SARS-CoV-2 placentitis. This observation was at odds with country's previous experience pregnant mothers.To describe clinical pathologic features these pregnancy losses.Retrospective review data cases miscarriage, stillbirth, or neonatal death identified by perinatal pathologists being due to placentitis during Ireland.Clinical available for pregnancies. Sequencing genotyping virus alpha (B.1.1.7) all cases. Three had maternal thrombocytopenia, fetal growth restriction not prominent, suggesting rapidly progressive disease.The identification suggests that emergence variant associated an increased risk when compared original virus. Maternal thrombocytopenia may have potential marker placentitis, but other inflammatory markers need investigation. women been assessed reduced movements hospital some days before deaths actually occurred; could suggest there be window intervention

Language: Английский

Citations

40
Placental response to maternal SARS-CoV-2 infection DOI Creative Commons
Mirella Mourad,

Taylor Jacob,

Elena Sadovsky

et al.

Scientific Reports, Journal Year: 2021, Volume and Issue: 11(1)

Published: July 13, 2021

The coronavirus disease 2019 (COVID-19) pandemic affected people at all ages. Whereas pregnant women seemed to have a worse course of than age-matched non-pregnant women, the risk feto-placental infection is low. Using cohort 66 COVID-19-positive in late pregnancy, we correlated clinical parameters with severity, placental histopathology, and expression viral entry Interferon-induced transmembrane (IFITM) antiviral transcripts. All newborns were negative for SARS-CoV-2. None demographic or histopathological characteristics associated severity. fetal-maternal transfer ratio IgG against N S proteins was commonly less one, as recently reported. We found that level ACE2, but not TMPRSS2 Furin, higher severe COVID-19. Placental IFITM1 IFITM3, which been implicated response, participants disease. also showed IFITM3 protein expression, localized early endosomes, enhanced Our data suggest an association between severity SARS-CoV-2 processing pathways, implying role these response

Language: Английский

Citations

50
Decidual immune response following COVID-19 during pregnancy varies by timing of maternal SARS-CoV-2 infection DOI Open Access
Lillian J. Juttukonda, Elisha M. Wachman, Jeffery Boateng

et al.

Journal of Reproductive Immunology, Journal Year: 2022, Volume and Issue: 151, P. 103501 - 103501

Published: Feb. 24, 2022

Language: Английский

Citations

31
A placental model of SARS-CoV-2 infection reveals ACE2-dependent susceptibility and differentiation impairment in syncytiotrophoblasts DOI Creative Commons
Joseph Chen,

Jessica A. Neil,

Jianping Tan

et al.

Nature Cell Biology, Journal Year: 2023, Volume and Issue: 25(8), P. 1223 - 1234

Published: July 13, 2023

Abstract SARS-CoV-2 infection causes COVID-19. Several clinical reports have linked COVID-19 during pregnancy to negative birth outcomes and placentitis. However, the pathophysiological mechanisms underpinning placentation early are not clear. Here, shed light on this, we used induced trophoblast stem cells generate an in vitro placenta model. We identified that syncytiotrophoblasts could be infected through angiotensin-converting enzyme 2 (ACE2). Using a co-culture model of vertical transmission, confirmed ability virus infect previous endometrial cell infection. further demonstrated transcriptional changes led impairment cellular processes, reduced secretion HCG hormone morphological vital for syncytiotrophoblast function. Furthermore, different antibody strategies antiviral drugs restore these impairments. In summary, established scalable tractable platform study placental types highlighted its use studying protect placenta.

Language: Английский

Citations

21
Clinical and in Vitro Evidence against Placenta Infection at Term by Severe Acute Respiratory Syndrome Coronavirus 2 DOI Creative Commons
Arthur Colson, Christophe Depoix,

Géraldine Dessilly

et al.

American Journal Of Pathology, Journal Year: 2021, Volume and Issue: 191(9), P. 1610 - 1623

Published: June 8, 2021

Language: Английский

Citations

36
Correlation between Pregnancy Outcome and Placental Pathology in COVID-19 Pregnant Women DOI Creative Commons
Sara A. Al-Rawaf,

Enas T. Mousa,

Noora M. Kareem

et al.

Infectious Diseases in Obstetrics and Gynecology, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 5

Published: Aug. 21, 2022

Background. Vertical transmission of several viruses during pregnancy has been shown to cause adverse fetal outcomes. The question about the possibility a similar outcome in association with SARS-CoV-2 raised recently published articles. Indeed, rate through placenta fetus reported women COVID-19 form minority. aim this study was explore possible histopathological changes pregnant after delivery and those umbilical cord. Methods. A case-control including total 50 full-term 60 control females. Histopathological evaluation placental tissues cords were reported. Results. main findings cord increased thickness vessels, thrombus formation, endothelins, narrow lumen; except for blood these more frequently seen COVID-19, comparison significant manner ( p < 0.05 ). Increased vessels significantly observed group compared id="M2"> 0.01 Findings included avascular villi, fibrin, thrombosis, meconium macrophage various combinations. Except fibrin as sole findings, all other combinations encountered id="M3"> Conclusion. Pregnant have pathological alterations These reflect capability causing immunological reactions placenta, either directly or indirectly, pathologies may be linked higher neonatal outcomes maternal admission intensive care unit.

Language: Английский

Citations

26