Multiple blood feeding bouts in mosquitoes allow for prolonged survival and are predicted to increase viral transmission during dry periods
iScience,
Journal Year:
2025,
Volume and Issue:
28(2), P. 111760 - 111760
Published: Jan. 9, 2025
Dry
conditions
increase
blood
feeding
in
mosquitoes,
but
it
is
unknown
if
dehydration-induced
bloodmeals
are
increased
beyond
what
necessary
for
reproduction.
In
this
study,
we
investigated
the
role
of
dehydration
secondary
behaviors
mosquitoes.
Following
an
initial
bloodmeal,
prolonged
exposure
to
dry
mosquitoes
by
nearly
two-fold,
and
chronic
allowed
survive
up
20
days
without
access
water.
Exposure
desiccating
following
a
bloodmeal
resulted
activity,
decreased
sleep
levels,
prompted
return
CO2
sensing
before
egg
deposition.
Increased
higher
survival
during
periods
predicted
pathogen
transmission,
allowing
rapid
rebound
mosquito
populations
when
favorable
return.
Overall,
these
results
solidify
our
understanding
how
impact
that
contributes
transmission
dynamics.
Language: Английский
Dehydration-induced Ae-Aper50 regulates midgut infection in Aedes aegypti mosquitoes
mBio,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 23, 2025
ABSTRACT
Climate
change
is
predicted
to
increase
the
spread
of
mosquito-borne
viruses,
but
genetic
mechanisms
underlying
influence
environmental
variation
on
ability
insect
vectors
transmit
human
pathogens
unknown.
In
response
a
changing
climate,
mosquitoes
will
experience
longer
periods
drought.
An
important
physiological
dry
environments
protection
against
dehydration,
here
defined
as
desiccation
tolerance.
While
temperature
known
impact
interactions
between
mosquito
and
virus,
role
dehydration
remains
We
identified
two
genetically
diverse
lines
Aedes
aegypti
,
major
arbovirus
vector,
with
marked
differences
in
To
determine
these
contrasting
lines,
we
compared
gene
expression
profiles
desiccant-
non-desiccant-treated
individuals
both
desiccation-tolerant
-susceptible
by
RNAseq.
Gene
analysis
demonstrated
that
several
genes
are
differentially
expressed
stress
lines.
The
most
highly
transcript
under
desiccation-susceptible
line
encodes
peritrophin
protein,
Ae-Aper50
.
Peritrophins
play
crucial
peritrophic
matrix
formation
midgut
after
bloodmeal.
silencing
RNAi
required
for
survival
stress,
not
line.
Moreover,
knockdown
resulted
higher
Zika
virus
(ZIKV)
infection
rates
increased
ZIKV
viral
replication
susceptible
line,
chikungunya
(CHIKV)
Altogether,
results
provide
link
infection,
which
has
implications
predicting
how
climate
viruses.
IMPORTANCE
have
profound
impacts
burden
viruses
transmitted
mosquitoes.
know
changes
physiology
dynamics
within
mosquito,
there
complete
lack
knowledge
low
humidity,
or
drought
tolerance,
arboviruses.
Understanding
tolerance
alter
arboviruses
critical
preventing
This
work
demonstrates
functional
infection.
significantly
enhances
our
understanding
droughts
could
Language: Английский
The impact of sugar diet on humidity preference, survival, and host landing in mosquitoes
Journal of Medical Entomology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 13, 2025
Mosquito-borne
diseases
have
caused
more
than
1
million
deaths
each
year.
There
is
an
urgent
need
to
develop
effective
way
reduce
mosquito-host
interaction
mitigate
disease
transmission.
Sugar
diets
long
been
linked
abnormal
physiology
in
animals,
making
them
potential
candidates
for
mosquito
control.
Here,
we
show
the
impact
of
sugar
on
humidity
preference
and
survival
Aedes
aegypti
(Gainesville)
Culex
pipiens
(Buckeye).
Two-choice
assays
with
high
low
relative
(80%
50%
RH)
that
species-specific.
In
comparison
Cx.
pipiens,
various
resulted
marked
reductions
avidity
Ae.
aegypti,
which
exhibited
significant
differences.
Among
diets,
arabinose
significantly
reduced
rate
mosquitoes
at
concentrations.
Moreover,
found
host
landing
was
not
impacted
by
feeding
different
types.
Our
study
suggests
specific
treatments
could
be
applied
control
dampening
their
reducing
lifespan,
thus
mosquito-borne
Language: Английский