An investigation into the transcription factors and regulatory mechanisms of Aspergillus DOI Creative Commons

Yuxin Qin,

Huan Yu, Jun Tian

et al.

Food Safety and Health, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 18, 2024

Abstract Aflatoxins produced by Aspergillus flavus , a group of filamentous fungi widely distributed in nature as foodborne pathogens, are major threat to food safety. It is thus clear that inextricably linked the sector. Transcription factors enable correct expression genes at specific spatial and temporal levels, they constitute considerable proportion fungal genome sequence. Their presence particularly important for growth, secondary metabolism, stress response, pathogenic process . This article reviews functional regulatory mechanisms transcription pathogen other species, current status research technologies, potential value applying them diverse fields such safety, biotechnology, medical health, agricultural output future.

Language: Английский

Leveraging endophytic fungi and multiomics integration for targeted drug discovery DOI
Aleena James Chirayimmel, Gursharan Kaur, Swapnil Kajale

et al.

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 277 - 293

Published: Jan. 1, 2025

Language: Английский

Citations

0
Discovering the hidden function in fungal genomes DOI Creative Commons
Nicholas C. Gervais, Rebecca S. Shapiro

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Sept. 19, 2024

Language: Английский

Citations

2
An auxin-inducible degron system for conditional mutation in the fungal meningitis pathogenCryptococcus neoformans DOI Open Access
Manning Y. Huang,

Matt J. Nalley,

Patrick Hecht

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 18, 2024

is the top-ranked W.H.O. fungal priority pathogen, but tools for generating conditional mutations are limited. Auxin-inducible degron systems permit rapid and effective cellular depletion of a tagged protein interest upon adding small molecule. These invaluable, particularly studying essential genes, which may play important roles in pathogen biology. AID2 one such system that improves on previous strategies. This achieves greater sensitivity specificity using "bumped" auxin, 5-Ph-IAA, alongside an OsTIR1(F74G) "hole" mutant. We adapted

Language: Английский

Citations

0
Going fishing: how to get what you want from a fungal genetic screen DOI Creative Commons
Teresa R. O’Meara

mSphere, Journal Year: 2024, Volume and Issue: 9(7)

Published: July 3, 2024

Five years ago, as I was starting my lab, wrote about two functional genomic screens in fungi that had inspired me (mSphere 4:e00299-19, https://doi.org/10.1128/mSphere.00299-19). Now, want to discuss some of the principles and questions ask myself students we embark on our own screens. A good screen, whether it is a genetic or chemical can be point for new discovery an excellent basis beginning scientific research project. However, are often criticized being "fishing expeditions." To stretch this metaphor extreme, because people worried do not know how fish, will come home without any bring wrong what with fish if caught it. How you set up screen analyze results determines useful. In mini-review, spirit teaching scientist recent fungal illustrate key aspects successful screen.

Language: Английский

Citations

0
An investigation into the transcription factors and regulatory mechanisms of Aspergillus DOI Creative Commons

Yuxin Qin,

Huan Yu, Jun Tian

et al.

Food Safety and Health, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 18, 2024

Abstract Aflatoxins produced by Aspergillus flavus , a group of filamentous fungi widely distributed in nature as foodborne pathogens, are major threat to food safety. It is thus clear that inextricably linked the sector. Transcription factors enable correct expression genes at specific spatial and temporal levels, they constitute considerable proportion fungal genome sequence. Their presence particularly important for growth, secondary metabolism, stress response, pathogenic process . This article reviews functional regulatory mechanisms transcription pathogen other species, current status research technologies, potential value applying them diverse fields such safety, biotechnology, medical health, agricultural output future.

Language: Английский

Citations

0