Ecological dynamics of Enterobacteriaceae in the human gut microbiome across global populations

Nature Microbiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract Gut bacteria from the Enterobacteriaceae family are a major cause of opportunistic infections worldwide. Given their prevalence among healthy human gut microbiomes, interspecies interactions may play role in modulating infection resistance. Here we uncover global ecological patterns linked to colonization and abundance by leveraging large-scale dataset 12,238 public metagenomes spanning 45 countries. Machine learning analyses identified robust microbiome signature associated with status, consistent across health states geographic locations. We classified 172 microbial species as co-colonizers 135 co-excluders, revealing genus-wide signal resistance within Faecalibacterium strain-specific co-colonization underexplored Faecalimonas phoceensis . Co-exclusion is functions involved short-chain fatty acid production, iron metabolism quorum sensing, while greater functional diversity metabolic resemblance Enterobacteriaceae. Our work underscores critical intestinal environment success gut-associated pathogens implications for developing non-antibiotic therapeutic strategies.

Language: Английский

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Integrated analysis of the microbiome, culturable strains, and substrate microenvironment reveals significant shifts in bacterial community of Angelica sinensis from fresh roots to medicinal slices

Biologia, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 15, 2025

Language: Английский

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Harnessing the human gut microbiota: an emerging frontier in combatting multidrug-resistant bacteria

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 17, 2025

Antimicrobial resistance (AMR) has become a major and escalating global health threat, undermining the effectiveness of current antibiotic antimicrobial therapies. The rise multidrug-resistant bacteria led to increasingly difficult-to-treat infections, resulting in higher morbidity, mortality, healthcare costs. Tackling this crisis requires development novel agents, optimization therapeutic strategies, initiatives infection surveillance control. Recent studies highlight crucial role human gut microbiota defending against AMR pathogens. A balanced protects body through mechanisms such as colonization resistance, positioning it key ally fight AMR. In contrast, dysbiosis disrupts defense, thereby facilitating persistence, colonization, dissemination resistant This review will explore how influence drug-resistant bacterial its involvement various types AMR-related potential for microbiota-targeted therapies, fecal transplantation, prebiotics, probiotics, phage therapy. Elucidating interactions between pathogens provide critical insights developing strategies prevent treat infections. While previous reviews have focused on general impact health, specifically look at latest research evolution spread AMR, highlighting strategies.

Language: Английский

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The Role of Short-Chain Fatty Acids in Metabolic Dysfunction-Associated Steatotic Liver Disease and Other Metabolic Diseases

Biomolecules, Journal Year: 2025, Volume and Issue: 15(4), P. 469 - 469

Published: March 22, 2025

With its increasing prevalence, metabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as a major global public health concern over the past few decades. Growing evidence proposed microbiota-derived metabolites short-chain fatty acids (SCFAs) potential factor in pathophysiology of MASLD and related conditions, such obesity type 2 diabetes mellitus (T2DM). By influencing key pathways involved energy homeostasis, insulin sensitivity, inflammation, SCFAs play an important role gut microbiota composition, intestinal barrier function, immune modulation, direct signaling. Furthermore, recent animal human studies on therapeutic strategies targeting demonstrate their for treating these disorders.

Language: Английский

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Use of postbiotics and parabiotics from lactobacilli in the treatment of infectious diarrhea

Microbial Pathogenesis, Journal Year: 2025, Volume and Issue: 204, P. 107580 - 107580

Published: April 12, 2025

Language: Английский

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Enhancing probiotic impact: engineering Saccharomyces boulardii for optimal acetic acid production and gastric passage tolerance

Applied and Environmental Microbiology, Journal Year: 2024, Volume and Issue: 90(6)

Published: May 16, 2024

has been a subject of growing interest due to its potential as probiotic microorganism with applications in gastrointestinal health, but the molecular cause for potency remained elusive. The recent discovery that

Language: Английский

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Microbiota-derived small molecule genotoxins: host interactions and ecological impact in the gut ecosystem

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Nov. 18, 2024

The human intestinal tract is densely colonized by a microbial community that subject to intense competition. Bacteria in this complex habitat seek outcompete their neighbors for nutrients and eliminate competitors with antibacterial toxins. Antagonism can be mediated diverse effectors including toxic proteins small molecule inhibitors are released extracellularly or delivered specialized secretion systems targeted cells. Two prototypical microbiota-derived enterotoxins, colibactin tilimycin, the newly discovered family of indolimines represent an expanding group non-proteinaceous molecules which specifically target DNA. In addition cell killing, they generate mutations genome instability intoxicated microbes host cells alike. They have been studied detail because direct toxicity important etiological roles pathologies. Increasing evidence, however, reveals these commensal genotoxins also mediators interbacterial antagonism, impacts gut ecology. review, we illustrate functional versatility ecosystem.

Language: Английский

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Leveraging Organ‐on‐Chip Models to Investigate Host–Microbiota Dynamics and Targeted Therapies for Inflammatory Bowel Disease

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 3, 2024

Abstract Inflammatory bowel disease (IBD) is an idiopathic gastrointestinal with drastically increasing incidence rates. Due to its multifactorial etiology, a precise investigation of the pathogenesis extremely difficult. Although reductionist cell culture models and more complex in animals have clarified understanding individual mechanisms contributing factors IBD past, it remains challenging bridge research clinical practice. Conventional 2D cannot replicate host–microbiota interactions stable long‐term microbial culture. Further, extrapolating data from animal patients due genetic environmental diversity leading differences immune responses. Human intestine organ‐on‐chip (OoC) emerged as alternative vitro model approach investigate IBD. OoC not only recapitulate human intestinal microenvironment accurately than cultures yet may also be advantageous for identification important disease‐driving pharmacological interventions targets possibility emulating different complexities. The predispositions biological hallmarks focusing on at mucosal barrier are elucidated here. Additionally, potential OoCs explore microbiota‐related therapies personalized medicine treatment discussed.

Language: Английский

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The microbiome’s influence on obesity: mechanisms and therapeutic potential

Science China Life Sciences, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 28, 2024

Language: Английский

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