Periodontal conditions and salivary microbiota are potential indicators to distinguish silicosis: an exploratory study DOI Creative Commons

Shaoying Duan,

Meiying Shao, Chenchen Zhang

et al.

BMC Microbiology, Journal Year: 2024, Volume and Issue: 24(1)

Published: Oct. 28, 2024

Silicosis has always been a serious global occupational health problem. Oral microbiota plays important roles in the development of lung disease. However, few studies have investigated relationship between periodontal conditions, oral bacteria and silicosis A single-center cross-sectional study was conducted 2019 Sichuan Province, China, including small sample patient group healthy control group. Demographic data examinations measured by clinical attachment loss (CAL), bleeding on probing (BOP) pocket (PD) were collected from each participant. Phenotypic changes detected histopathological staining. Next-generation sequencing targeting 16S ribosomal RNA targeted to decipher salivary microbiome two groups. Random forest, Least Absolute Shrinkage Selection Operator (LASSO) logistic regression multivariable analysis find potential indicators distinguish silicosis. In general, 29 male controls 24 patients included. The proportion CAL ≥ 3 mm greater than group, while BOP (+) PD 4 reduced α-smooth muscle actin fibronectin expression increased gingiva patients. composition exhibited significant differences groups, with demonstrating lower diversity microbiota. Genus Aggregatibacter [odds ratio (OR) = 0.000, p 0.003] Catonella (OR 0.049) identified as biomarkers worse CAL, improved PD, which may be related gingival fibrosis found this study. underwent changes, accompanied decrease diversity, Our indicates that respirable crystalline silica exposure affects health, alterations might implicated We primarily controls.

Language: Английский

The dynamic oral–gastric microbial axis connects oral and gastric health: current evidence and disputes DOI Creative Commons
Mengying Xia, Lei Lei, Lin-Yong Zhao

et al.

npj Biofilms and Microbiomes, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 2, 2025

Emerging evidence indicates that oral microbes are closely related to gastric and lesions, including atrophy, intestinal metaplasia cancer (GC). Helicobacter pylori is a key pathogen involved in GC. However, the increasing prevalence of H. pylori-negative GC dysbiosis patients emphasize potential role other microbial factors. In this review, we discussed current about relationship between oral–gastric axis health. Epidemiologic poor hygiene greater risk. Multiple oral-associated enriched stomach patients. Once colonizing stomach, Streptococcus anginosus Prevotella melaninogenica, inflammation or carcinogenesis. Microbial metabolites such as lactate, nitrite, acetaldehyde promote malignant transformation. The checkpoint transmission digestive tract, great importance since link diseases has been emphasized. Still, new technologies standardized metrics necessary identify pathogenetic for core microbiota, interactions, richness, colonization, location effect (CIRCLE). future, could be candidates noninvasive indicators predict diseases.

Language: Английский

Citations

3
Advances in 16S rRNA‐Based Microbial Biomarkers for Gastric Cancer Diagnosis and Prognosis DOI Creative Commons
Yingying Wang,

Xunan Qiu,

Aining Chu

et al.

Microbial Biotechnology, Journal Year: 2025, Volume and Issue: 18(2)

Published: Feb. 1, 2025

ABSTRACT Gastric cancer (GC) is a malignant tumour with high morbidity and mortality worldwide, there an urgent need for early diagnosis precision treatment. In recent years, the role of microbiota in occurrence development GC has drawn extensive attention. Particularly, in‐depth study GC‐related by 16S rRNA sequencing technology offered valuable tools new perspectives exploring microbial characteristics patients. This review systematically summarises diversity composition non‐GC samples based on data, outlines progress identifying biomarkers, explores potential mechanisms which diagnostic biomarkers influence GC, reflects limitations present studies. By integrating current evidence, this intends to offer theoretical foundation further direction clinical translation research treatment GC.

Language: Английский

Citations

0
Gastric Cardiac Carcinoma: Recent Progress in Clinicopathology, Prognosis, and Early Diagnosis DOI Open Access
Qin Huang,

Yu Qing Cheng,

K. Hu

et al.

Journal of Digestive Diseases, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

ABSTRACT Gastric cardiac carcinoma (GCC), also known as gastroesophageal junction (GEJ) carcinoma, is a slow‐growing fatal cancer that arises in gastric mucosa region of about 2 cm above and 3 below the GEJ line. This shows clinicopathologic genomic features similar, but not identical, to noncardiac (GNCC). In contrast, GCC much more complicated than esophageal adenocarcinoma (EA) clinicopathology, genomics, prognosis. heterogeneous geographically, accounting for 20%–50% all carcinomas endemic regions China. Compared with EA, broader histopathologic spectrum worse Although detailed mechanisms pathogenesis remain elusive, advanced age, Helicobacter pylori infection, reflux disease are key risk factors. Intriguingly, goblet cell intestinal metaplasia may be an essential initial step toward carcinogenesis cases. At present, accurate diagnosis early prompt curative resection only realistic hope dramatically improving patient outcomes. The recently developed liquid biopsy technology serum cell‐free DNA promising tool detection GCC, though many challenges in‐depth investigation required. Given recent rapid advances artificial intelligence, endoscopic technology, better understanding endoscopists subtle mucosal/vascular changes high proportion cases would possible.

Language: Английский

Citations

0
Oral microbes and gastrointestinal cancers: new strategies and insights DOI
Chenlu Huang,

Yu Li,

Cong He

et al.

Clinical & Translational Oncology, Journal Year: 2025, Volume and Issue: unknown

Published: April 5, 2025

Language: Английский

Citations

0
The association between oral microbiome and gastric precancerous lesions DOI Creative Commons
Yifei Chen, Lei Lei, Mengying Xia

et al.

mSystems, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 4, 2024

ABSTRACT Gastric precancerous lesions are thought to be precursors in the occurrence and development of gastric cancer through Correa's cascade. Recent studies have investigated association between oral microbiome lesions. However, there has yet a comprehensive synthesis review existing literature on relationship A systematic was conducted characterize The show that is dynamic individuals with Oral-derived microorganisms were colonized Interactions microbiomes affect response host immunity. abnormal proliferation oral-associated may linked reduction acid. present supports potential interactions complex multifaceted, which require further investigation.

Language: Английский

Citations

1
Periodontal conditions and salivary microbiota are potential indicators to distinguish silicosis: an exploratory study DOI Creative Commons

Shaoying Duan,

Meiying Shao, Chenchen Zhang

et al.

BMC Microbiology, Journal Year: 2024, Volume and Issue: 24(1)

Published: Oct. 28, 2024

Silicosis has always been a serious global occupational health problem. Oral microbiota plays important roles in the development of lung disease. However, few studies have investigated relationship between periodontal conditions, oral bacteria and silicosis A single-center cross-sectional study was conducted 2019 Sichuan Province, China, including small sample patient group healthy control group. Demographic data examinations measured by clinical attachment loss (CAL), bleeding on probing (BOP) pocket (PD) were collected from each participant. Phenotypic changes detected histopathological staining. Next-generation sequencing targeting 16S ribosomal RNA targeted to decipher salivary microbiome two groups. Random forest, Least Absolute Shrinkage Selection Operator (LASSO) logistic regression multivariable analysis find potential indicators distinguish silicosis. In general, 29 male controls 24 patients included. The proportion CAL ≥ 3 mm greater than group, while BOP (+) PD 4 reduced α-smooth muscle actin fibronectin expression increased gingiva patients. composition exhibited significant differences groups, with demonstrating lower diversity microbiota. Genus Aggregatibacter [odds ratio (OR) = 0.000, p 0.003] Catonella (OR 0.049) identified as biomarkers worse CAL, improved PD, which may be related gingival fibrosis found this study. underwent changes, accompanied decrease diversity, Our indicates that respirable crystalline silica exposure affects health, alterations might implicated We primarily controls.

Language: Английский

Citations

0