Geographic social vulnerability is associated with the alpha diversity of the human microbiome

mSystems, Journal Year: 2023, Volume and Issue: 8(5)

Published: Aug. 29, 2023

As a risk factor for conditions related to the microbiome, understanding role of SVI on microbiome diversity may assist in identifying public health implications research. Here we found, using sub-sample Human Microbiome Project phase 1 cohort, that was linked across body sites and influence race/ethnicity-based differences diversity. Our findings, build current knowledge regarding human geography research, suggest measures geographic social vulnerability be considered as additional contextual factors when exploring alpha

Language: Английский

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Individual Nutrition Is Associated with Altered Gut Microbiome Composition for Adults with Food Insecurity

Nutrients, Journal Year: 2022, Volume and Issue: 14(16), P. 3407 - 3407

Published: Aug. 19, 2022

Diet is widely recognized as a key contributor to human gut microbiome composition and function. However, overall nutrition can be difficult compare across population with varying diets. Moreover, the role of food security in relationship unclear. This study aims investigate association between personalized scores, variation adult microbiome, modification by insecurity. The data originate from Survey Health Wisconsin Microbiome Study. Individual scores were assessed using My Nutrition Index (MNI), calculated frequency questionnaires, additional health history demographic surveys. Food covariate measured through self-reported questionnaires. was 16S amplicon sequencing DNA extracted stool samples. Associations, adjusted for confounding interaction security, estimated Weighted Quantile Sum (WQS) regression models Random Subset Repeated Holdout extensions (WQSRSRH), bacterial taxa used components weighted index. Of 643 participants, average MNI 66.5 (SD = 31.9), 22.8% participants insecure. Increased significantly associated altered microbial (β 2.56, 95% CI 0.52−4.61), Ruminococcus, Oscillospira, Blautia among most heavily 21 genera score. In stratified WQSRSRH models, differed but level not different. More are important higher people insecurity versus including Streptococcus, Parabacteroides Faecalibacterium, Desulfovibrio. differences composition. vary security. While further investigation needed, results showed score wider range insecure vs. secure, suggesting nutritional quality individuals maintaining reducing disparities.

Language: Английский

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Deciphering the Microbiome: Integrating Theory, New Technologies, and Inclusive Science

mSystems, Journal Year: 2022, Volume and Issue: 7(5)

Published: Sept. 8, 2022

The diversity and functional significance of microbiomes have become increasingly clear through the extensive sampling Earth's many habitats rapid adoption new sequencing technologies. However, much remains unknown about what makes a "healthy" microbiome, how to restore disrupted assemble. In December 2019, we convened workshop that focused on identify potential "rules life" govern microbiome structure function. This collection mSystems Perspective pieces reflects main challenges opportunities in field identified by both in-person virtual participants. By borrowing conceptual theoretical approaches from other fields, including economics philosophy, these suggest ways dissect patterns processes. application advances, trait-based theory community coalescence, is providing insights predict manage Technological analytical deep transfer learning, metabolic models, advances chemistry, are helping us sift complex systems pinpoint mechanisms assembly dynamics. Integration all advancements (theory, concepts, technology) across biological spatial scales dramatically improved temporal resolution integrative research happening moment science where academic institutions, scientific societies, funding agencies must act collaboratively support train diverse inclusive scientists.

Language: Английский

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The intersection of social determinants of health, the microbiome, and health outcomes in immigrants: A scoping review

American Journal of Physical Anthropology, Journal Year: 2023, Volume and Issue: 183(1), P. 3 - 19

Published: Sept. 22, 2023

In the present scoping review, we explore whether existing evidence supports premise that social determinants of health (SDoH) affect immigrant outcomes through their effects on microbiome. We adapt National Institute Minority Health and Disparities' research framework to propose a conceptual model considers intersection SDoH, microbiome, in immigrants. use this as lens which recent about biological factors associated with changes immigrants' microbiomes, long-term outcomes. 17 articles reviewed, dietary acculturation, physical activity, ethnicity, birthplace, age at migration length time host country, socioeconomic status, social/linguistic acculturation were important postmigration microbiome-related transformations. These are progressive shifts microbiome profile increasing risks for cardiometabolic, mental, immune, inflammatory disorders antibiotic resistance. The thus SDoH influence postmigration, least part, Omission social-ecological variables (e.g., stress, racism, social/family relationships, environment), limited among minoritized subgroups immigrants, complexity inter- intra-individual differences interdisciplinary biosocial collaboration restrict our understanding area study. To identify potential microbiome-based interventions promote well-being, more is necessary understand intersections from biological, behavioral/psychosocial, physical/built environment, sociocultural environment domains all levels.

Language: Английский

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Advancing microbiome research in Māori populations: insights from recent literature exploring the gut microbiomes of underrepresented and Indigenous peoples

mSystems, Journal Year: 2024, Volume and Issue: 9(11)

Published: Oct. 4, 2024

ABSTRACT The gut microbiome plays vital roles in human health, including mediating metabolism, immunity, and the gut-brain axis. Many ethnicities remain underrepresented research, with significant variation between Indigenous non-Indigenous peoples due to dietary, socioeconomic, urbanization differences. Although research regarding microbiomes of is increasing, Māori literature lacking despite widespread inequities that populations face. These likely contribute differences exacerbate negative health outcomes. Characterizing necessary inform efforts address inequities. However, for be culturally responsible meaningful, study design must improve better protect rights interests peoples. Here, we discuss barriers participation role disparities may play shaping peoples, a particular focus on implications areas improvement.

Language: Английский

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