The Baseline Gut Microbiota Directs Dieting-Induced Weight Loss Trajectories

Gastroenterology, Journal Year: 2021, Volume and Issue: 160(6), P. 2029 - 2042.e16

Published: Jan. 20, 2021

Language: Английский

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The Effect of Dietary Interventions on Chronic Inflammatory Diseases in Relation to the Microbiome: A Systematic Review

Nutrients, Journal Year: 2021, Volume and Issue: 13(9), P. 3208 - 3208

Published: Sept. 15, 2021

Chronic inflammation plays a central role in the pathophysiology of various non-communicable diseases. Dietary interventions can reduce inflammation, part due to their effect on gut microbiome. This systematic review aims determine dietary interventions, specifically fiber intake, chronic inflammatory diseases and It form hypotheses potential mediating effects microbiome disease outcomes after changes. Included were clinical trials which performed intervention with whole diet change or supplement (>5 g/day) investigated patients diagnosed such as cardiovascular (CVD), type 2 diabetes (T2DM), autoimmune (e.g., rheumatoid arthritis (RA), bowel (IBD)). The 30 articles met inclusion criteria had an overall moderate high risk bias too heterogeneous perform meta-analysis. stratified based intake: low fiber, supplemental fiber. Overall, but most pronounced T2DM, high-fiber plant-based consistently more effective at reducing disease-specific pathogenic bacteria, well increasing alpha diversity short-chain fatty acid (SCFA)-producing compared other diets supplements.

Language: Английский

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Mediterranean Diet to Prevent the Development of Colon Diseases: A Meta-Analysis of Gut Microbiota Studies

Nutrients, Journal Year: 2021, Volume and Issue: 13(7), P. 2234 - 2234

Published: June 29, 2021

Gut microbiota dysbiosis is a common feature in colorectal cancer (CRC) and inflammatory bowel diseases (IBD). Adoption of the Mediterranean diet (MD) has been proposed as therapeutic approach for prevention multiple diseases, one its mechanisms action modulation microbiota. We aimed to determine whether MD can be used preventive measure against inflammation-related gut, based on capacity modulate local A joint meta-analysis publicly available 16S data derived from subjects following or other diets patients with CRC, IBD, gut-related was conducted. observed that associated enriched bacteria promote an anti-inflammatory environment but low taxa pro-inflammatory properties capable altering intestinal barrier functions. found opposite trend including cancer. Some these differences were maintained even when compared healthy controls without defined diet. Our findings highlight unique effects gut suggest integrating principles into person's lifestyle may serve method diseases.

Language: Английский

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Multi-omics study reveals that statin therapy is associated with restoration of gut microbiota homeostasis and improvement in outcomes in patients with acute coronary syndrome

Theranostics, Journal Year: 2021, Volume and Issue: 11(12), P. 5778 - 5793

Published: Jan. 1, 2021

Prior chronic treatment with statins has been shown to be associated more favorable outcomes in patients acute coronary syndrome (ACS). Specific changes the gut microbiota and microbial metabolites have influence progression of artery disease. However, critical metabolomic cardiovascular protective effects ACS remain elusive.

Language: Английский

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Altered Fecal Microbiota Composition in Older Adults With Frailty

Frontiers in Cellular and Infection Microbiology, Journal Year: 2021, Volume and Issue: 11

Published: Aug. 17, 2021

Frailty is a common geriatric syndrome that diagnosed and staged based mainly on symptoms. We aimed to evaluate frailty-related alterations of the intestinal permeability profile fecal microbiota healthy frail older adults identify microbial biomarkers this syndrome.We collected serum samples from 94 community-dwelling adults, along with anthropometric, medical, mental health, lifestyle data. Serum inflammatory cytokines IL-6 HGMB1 biomarker zonulin were measured using enzyme-linked immunosorbent assays. The 16S rRNA amplicon sequencing method was performed determine composition microbiota. analyzed diversity differences gut in two groups assessed relationship between changes structure clinical biomarkers.Older frailty showed higher concentrations IL-6, HGMB1, zonulin. Although there no statistically significant index evenness indices or species richness groups, we found differences. Compared control group, group had levels Akkermansia, Parabacteroides, Klebsiella lower commensal genera Faecalibacterium, Prevotella, Roseburia, Megamonas, Blautia. Spearman's correlation analysis intergenus interactions more controls than frailty. Escherichia/Shigella, Pyramidobacter, Alistipes, Akkermansia positively correlated while Roseburia negatively IL-6. Alistipes be HGMB1. linked increased level factors permeability.Frailty associated These findings might aid development probiotics microbial-based therapies for

Language: Английский

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The Relationship Between Pediatric Gut Microbiota and SARS-CoV-2 Infection

Frontiers in Cellular and Infection Microbiology, Journal Year: 2022, Volume and Issue: 12

Published: July 8, 2022

This is the first study on gut microbiota (GM) in children affected by coronavirus disease 2019 (COVID-19). Stool samples from 88 patients with suspected severe acute respiratory syndrome 2 (SARS-CoV-2) infection and 95 healthy subjects were collected (admission: 3–7 days, discharge) to GM profile 16S rRNA gene sequencing relationship severity. The group was divided COVID-19 (68), Non–COVID-19 (16), MIS-C (multisystem inflammatory children) (4). Correlations among ecology, predicted functions, multiple machine learning (ML) models, response provided for cohorts. of cohort resulted as dysbiotic, lowest α-diversity compared CTRLs a specific β-diversity. Its appeared enriched Faecalibacterium , Fusobacterium Neisseria reduced Bifidobacterium Blautia Ruminococcus Collinsella Coprococcus Eggerthella Akkermansia ( p < 0.05). All paired-comparisons disclosed comparable results through all time points. comparison between cohorts highlighted reduction Abiotrophia characterized an increase Veillonella Clostridium Dialister Streptococcus decrease Granulicatella Prevotella CTRLs. Stratifying severity, associated “moderate” lower “mild” “asymptomatic” deprived Lachnospira Acidaminococcus Oscillospora Alistipes Bacteroides. ML models identified Staphylococcus Anaerostipes Dorea Roseburia Haemophilus Gemmiger Corynebacterium Bilophila Phascolarctobacterium Oscillospira microbial markers COVID-19. KEGG ortholog (KO)–based prediction functional 28 39 KO-associated pathways CTRLs, respectively. Finally, Bacteroides Sutterella correlated proinflammatory cytokines regardless Unlike adult profiles, marker pediatric GM. durable modification patients’ suggested prompt quenching SARS-CoV-2 since symptoms. fatty acid amino degradation proposed traits, possibly restrained severity SARS-CoV-2–infected children. Altogether, this evidence provides characterization COVID-19–related

Language: Английский

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Nutritional Modulation of Gut Microbiota Alleviates Severe Gastrointestinal Symptoms in a Patient with Post-Acute COVID-19 Syndrome

mBio, Journal Year: 2022, Volume and Issue: 13(2)

Published: March 7, 2022

With the increase in total coronavirus disease 2019 (COVID-19) infection cases, post-acute COVID-19 syndrome, defined as experiencing ongoing health problems 4 or more weeks after first severe acute respiratory syndrome 2 (SARS-CoV-2) infection, has become a new arising public concern. As part of gastrointestinal symptoms might be associated with dysbiosis gut microbiota, which potential to target for intervention. In this study, patient long-lasting was provided 2-month expanded access high-fiber formula investigational drug (IND) status developed alleviate COVID-19-related by modulating microbiota. Symptoms including "loss appetite," palpitation, and anxiety were significantly alleviated end The medication dosage controlling nausea decreased during serum lipid profile, insulin level, leptin level improved compared baseline values. Significant structural changes patient's microbiota reduced microbial fermentation activity small intestine found Eighteen amplicon sequence variants (ASVs) V4 region 16S rRNA gene responded nutritional Six out 18 ASVs also negatively correlated symptom severity/medication dosage. Five six (ASV0AKS_Oscillibacter, ASV009F_Anaerofustis, ASV02YT_Blautia, ASV07LA_Blautia, ASV0AM6_Eubacterium hallii) short-chain fatty acid (SCFA)-producing bacteria, alleviation symptoms. Our study indicates feasibility alleviating patients way modulation their IMPORTANCE It evident that care does not at time negative SARS-CoV-2 detection, number increases an ever-increasing infected population. This case report shows possibility via microbiota-targeted promising strategy, it only improve quality life but reduce burden system when pandemic is sight.

Language: Английский

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Regulatory effects mediated by ulvan oligosaccharide and its zinc complex on lipid metabolism in high-fat diet-fed mice

Carbohydrate Polymers, Journal Year: 2022, Volume and Issue: 300, P. 120249 - 120249

Published: Oct. 22, 2022

Language: Английский

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Faecal Microbiota transplantation affects liver DNA methylation in Non-alcoholic fatty liver disease: a multi-omics approach

Gut Microbes, Journal Year: 2023, Volume and Issue: 15(1)

Published: June 14, 2023

Individuals with nonalcoholic fatty liver disease (NAFLD) have an altered gut microbiota composition. Moreover, hepatic DNA methylation may be in the state of NAFLD. Using a fecal transplantation (FMT) intervention, we aimed to investigate whether change composition relates assessed plasma metabolite profiles by FMT relate changes methylation. Twenty-one individuals NAFLD underwent three 8-weekly vegan allogenic donor (n = 10) or autologous 11) FMTs. We obtained from paired biopsies study participants before and after applied multi-omics machine learning approach identify microbiome, peripheral blood metabolome methylome, analyzed cross-omics correlations. Vegan compared induced distinct differential I) profiles, including increased abundance Eubacterium siraeum potential probiotic Blautia wexlerae; II) metabolites, levels phenylacetylcarnitine (PAC) phenylacetylglutamine (PAG) both gut-derived phenylacetic acid, several choline-derived long-chain acylcholines; III) most importantly Threonyl-TRNA Synthetase 1 (TARS) Zinc finger protein 57 (ZFP57). Multi-omics analysis showed that Gemmiger formicillis Firmicutes bacterium_CAG_170 positively correlated PAC PAG. E negatively cg16885113 ZFP57. Alterations caused widespread metabolites (e.g. PAC, PAG, metabolites) These results indicate FMTs might induce metaorganismal pathway changes, bacteria liver.

Language: Английский

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Strain-level screening of human gut microbes identifies Blautia producta as a new anti-hyperlipidemic probiotic

Gut Microbes, Journal Year: 2023, Volume and Issue: 15(1)

Published: July 5, 2023

Compelling evidence has tightly linked gut microbiota with host metabolism homeostasis and inspired novel therapeutic potentials against metabolic diseases (e.g., hyperlipidemia). However, the regulatory profile of individual bacterial species strain on lipid remains largely unknown. Herein, we performed a large-scale screening 2250 human strains (186 species) for lipid-decreasing activity. Different in same usually displayed distinct lipid-modulatory actions, showing evident strain-specificity. Among tested strains, Blautia producta exhibited most potency to suppress cellular accumulation effectively ameliorated hyperlipidemia high fat diet (HFD)-feeding mice. Taking joint comparative approach pharmacology, genomics metabolomics, identified an anteiso-fatty acid, 12-methylmyristic acid (12-MMA), as key active metabolite Bl. Producta. In vivo experiment confirmed that 12-MMA could exert potent hyperlipidemia-ameliorating efficacy improve glucose via activating G protein-coupled receptor 120 (GPR120). Altogether, our work reveals previously unreported microbes at level, emphasizes strain-specific function bacteria, provides possibility develop microbial therapeutics based its metabolite.

Language: Английский

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