The power of microbes: the key role of gut microbiota in the initiation and progression of colorectal cancer DOI Creative Commons
Bo Han, Yanwen Zhang, Feng Xue

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: April 14, 2025

Colorectal cancer (CRC) is ranked as the third most prevalent malignancy and a leading cause of cancer-related mortality globally, significantly affecting health longevity middle-aged individuals elderly. The primary risk factors for CRC are mainly due to unhealthy dietary habits lifestyle choices, they have been shown profoundly influence composition gut microbiota. Given that patterns critical determinants microbial diversity, compelling association exists between microbiota pathogenesis CRC. Recent research has increasingly focused on intricate interplay CRC, exploring its role in disease initiation, progression, modulation host immune responses. Investigations demonstrated certain specific communities can promote inflammation, disrupt metabolic pathways, produce carcinogenic compounds, thereby contributing development Conversely, diverse balanced microbiome may confer protective effects against through mechanisms such production short-chain fatty acids enhancement intestinal barrier integrity. This article provides comprehensive overview characteristics community complex relationship with It highlights potential which pathogenesis, including chronic toxins, metabolites, epigenetic dysregulation, regulatory dysfunction. Additionally, this review summarizes innovative strategies prevention treatment, emphasizing therapeutic probiotics natural plant extracts. By elucidating these connections, work aims enhance understanding microbiome’s

Language: Английский

The power of microbes: the key role of gut microbiota in the initiation and progression of colorectal cancer DOI Creative Commons
Bo Han, Yanwen Zhang, Feng Xue

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: April 14, 2025

Colorectal cancer (CRC) is ranked as the third most prevalent malignancy and a leading cause of cancer-related mortality globally, significantly affecting health longevity middle-aged individuals elderly. The primary risk factors for CRC are mainly due to unhealthy dietary habits lifestyle choices, they have been shown profoundly influence composition gut microbiota. Given that patterns critical determinants microbial diversity, compelling association exists between microbiota pathogenesis CRC. Recent research has increasingly focused on intricate interplay CRC, exploring its role in disease initiation, progression, modulation host immune responses. Investigations demonstrated certain specific communities can promote inflammation, disrupt metabolic pathways, produce carcinogenic compounds, thereby contributing development Conversely, diverse balanced microbiome may confer protective effects against through mechanisms such production short-chain fatty acids enhancement intestinal barrier integrity. This article provides comprehensive overview characteristics community complex relationship with It highlights potential which pathogenesis, including chronic toxins, metabolites, epigenetic dysregulation, regulatory dysfunction. Additionally, this review summarizes innovative strategies prevention treatment, emphasizing therapeutic probiotics natural plant extracts. By elucidating these connections, work aims enhance understanding microbiome’s

Language: Английский

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