Factors associated with severe acute respiratory syndrome-related coronavirus 2 infection in unvaccinated children and young adults DOI Creative Commons
Sarah L. Silverberg, Hennady P. Shulha,

Brynn McMillan

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 16, 2023

ABSTRACT BACKGROUND Pediatric COVID-19 cases are often mild or asymptomatic, which has complicated estimations of disease burden using existing testing practices. We aimed to determine the age-specific population seropositivity and risk factors SARS-CoV-2 among children young adults during pandemic in British Columbia (BC). METHODS conducted two cross-sectional serosurveys: phase 1 enrolled <25 years between November 2020-May 2021 2 <10 June 2021-May 2022 BC. Participants completed electronic surveys self-collected finger-prick dried blood spot (DBS) samples. Samples were tested for immunoglobulin G antibodies against ancestral spike protein (S). Descriptive statistics from survey data reported multivariable analyses evaluate associated with seropositivity. RESULTS A total 2864 participants enrolled, 95/2167 (4.4%) S-seropositive across all ages, 61/697 (8.8%) unvaccinated aged under ten 2. Overall, South Asian had a higher than other ethnicities (13.5% vs. 5.2%). Of 156 seropositive both phases, 120 no prior positive test. Young infants highest rates (7.0% 7.2% respectively 3.0-5.6% age groups). CONCLUSION was low May 2022, Asians disproportionately infected. This work demonstrates need improved diagnostics reporting strategies that account differences dynamics acceptability mechanisms.

Language: Английский

What is the specific role of schools and daycares in COVID-19 transmission? A final report from a living rapid review DOI
Sarah Neil‐Sztramko, Emily Belita, Robyn Traynor

et al.

The Lancet Child & Adolescent Health, Journal Year: 2024, Volume and Issue: 8(4), P. 290 - 300

Published: Feb. 15, 2024

Language: Английский

Citations

9
SARS-CoV-2 seroprevalence among Vancouver public school staff in British Columbia, Canada: a cross-sectional study DOI Creative Commons
David A. Goldfarb, Louise C. Mâsse, Allison W. Watts

et al.

BMJ Open, Journal Year: 2022, Volume and Issue: 12(4), P. e057846 - e057846

Published: April 1, 2022

Few studies reported COVID-19 cases in schools during the 2020/21 academic year a setting of uninterrupted in-person schooling. The main objective was to determine SARS-CoV-2 seroprevalence among school staff Vancouver public schools.

Language: Английский

Citations

19
Lower transmissibility of SARS-CoV-2 among asymptomatic cases: evidence from contact tracing data in Oslo, Norway DOI Creative Commons
Fredrik Methi, Elisabeth Henie Madslien

BMC Medicine, Journal Year: 2022, Volume and Issue: 20(1)

Published: Nov. 8, 2022

Abstract Background Asymptomatic COVID-19 cases have complicated the surveillance and tracking of pandemic. Previous studies estimated that 15–25% all infectees remain asymptomatic. Methods Based on contact tracing data from Oslo, Norway, we transmission susceptibility dynamics among symptomatic asymptomatic their contacts as identified by manual between September 1, 2020, 2021. Results Among 27,473 indexes 164,153 registered contacts, secondary attack rate (SAR-14) was to be 28% lower through exposure (13%) compared (18%). Furthermore, those infected were almost three times more likely cases. Conclusions Symptomatic spread virus a greater extent than asymptomatic, are if assumed infector

Language: Английский

Citations

14
SARS-CoV-2 cross-sectional seroprevalence study among public school staff in Metro Vancouver after the first Omicron wave in British Columbia, Canada DOI Creative Commons
Allison W. Watts, Louise C. Mâsse, David A. Goldfarb

et al.

BMJ Open, Journal Year: 2023, Volume and Issue: 13(6), P. e071228 - e071228

Published: June 1, 2023

Objective To determine the SARS-CoV-2 seroprevalence among school workers within Greater Vancouver area, British Columbia, Canada, after first Omicron wave. Design Cross-sectional study by online questionnaire, with blood serology testing. Setting Three main districts (Vancouver, Richmond and Delta) in metropolitan area. Participants Active staff enrolled from January to April 2022, testing between 27 8 2022. Seroprevalence estimates were compared data obtained Canadian donors weighted over same sampling period, age, sex postal code distribution. Primary secondary outcomes nucleocapsid antibody results adjusted for test sensitivity specificity, regional variation across using Bayesian models. Results Of 1850 enrolled, 65.8% (1214/1845) reported close contact a COVID-19 case outside household. those contacts, 51.5% (625/1214) student 54.9% (666/1214) coworker. Cumulative incidence of positive self-reported nucleic acid or rapid antigen since beginning pandemic was 15.8% (291/1845). In representative sample 1620 who completed (87.6%), 26.5% (95% CrI 23.9% 29.3%), 32.4% 30.6% 34.5%) 7164 donors. Conclusion Despite frequent exposures reported, this setting remained no greater than community reference group. are consistent premise that many infections acquired setting, even Omicron.

Language: Английский

Citations

7
Factors associated with SARS-CoV-2 infection in unvaccinated children and young adults DOI Creative Commons
Sarah L. Silverberg, Hennady P. Shulha,

Brynn McMillan

et al.

BMC Infectious Diseases, Journal Year: 2024, Volume and Issue: 24(1)

Published: Jan. 15, 2024

Abstract Background and objectives Pediatric COVID-19 cases are often mild or asymptomatic, which has complicated estimations of disease burden using existing testing practices. We aimed to determine the age-specific population seropositivity risk factors SARS-CoV-2 among children young adults during pandemic in British Columbia (BC). Methods conducted two cross-sectional serosurveys: phase 1 enrolled < 25 years between November 2020-May 2021 2 10 June 2021-May 2022 BC. Participants completed electronic surveys self-collected finger-prick dried blood spot (DBS) samples. Samples were tested for immunoglobulin G antibodies against ancestral spike protein (S). Descriptive statistics from survey data reported multivariable analyses evaluate associated with seropositivity. Results A total 2864 participants enrolled, 95/2167 (4.4%) S-seropositive across all ages, 61/697 (8.8%) unvaccinated aged under ten 2. Overall, South Asian had a higher than other ethnicities (13.5% vs. 5.2%). Of 156 seropositive both phases, 120 no prior positive test. Young infants highest rates (7.0% 7.2% respectively 3.0-5.6% age groups). Conclusions was low May 2022, Asians disproportionately infected. This work demonstrates need improved diagnostics reporting strategies that account differences dynamics acceptability mechanisms.

Language: Английский

Citations

1
Secondary infections of COVID-19 in schools and the effectiveness of school-based interventions: a systematic review and meta-analysis DOI
Baohua Zheng, Huanwen Chen, Wenfang Xia

et al.

Public Health, Journal Year: 2024, Volume and Issue: 229, P. 42 - 49

Published: Feb. 23, 2024

Language: Английский

Citations

1
Factors associated with severe acute respiratory syndrome-related coronavirus 2 infection in unvaccinated children and young adults DOI Creative Commons
Sarah L. Silverberg, Hennady P. Shulha,

Brynn McMillan

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 16, 2023

ABSTRACT BACKGROUND Pediatric COVID-19 cases are often mild or asymptomatic, which has complicated estimations of disease burden using existing testing practices. We aimed to determine the age-specific population seropositivity and risk factors SARS-CoV-2 among children young adults during pandemic in British Columbia (BC). METHODS conducted two cross-sectional serosurveys: phase 1 enrolled <25 years between November 2020-May 2021 2 <10 June 2021-May 2022 BC. Participants completed electronic surveys self-collected finger-prick dried blood spot (DBS) samples. Samples were tested for immunoglobulin G antibodies against ancestral spike protein (S). Descriptive statistics from survey data reported multivariable analyses evaluate associated with seropositivity. RESULTS A total 2864 participants enrolled, 95/2167 (4.4%) S-seropositive across all ages, 61/697 (8.8%) unvaccinated aged under ten 2. Overall, South Asian had a higher than other ethnicities (13.5% vs. 5.2%). Of 156 seropositive both phases, 120 no prior positive test. Young infants highest rates (7.0% 7.2% respectively 3.0-5.6% age groups). CONCLUSION was low May 2022, Asians disproportionately infected. This work demonstrates need improved diagnostics reporting strategies that account differences dynamics acceptability mechanisms.

Language: Английский

Citations

0