Deep‐Tissue In Vivo Imaging Using Bioluminescence in a Mouse Infection Model and the Path to High Sensitivity With Near‐Infrared Luminescence DOI

Daiki Yamaguchi,

Kenji Oki,

Yuki Kaya

et al.

Microbiology and Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

ABSTRACT The analysis of bacterial infections using animal models has primarily relied on the average evaluation many individuals at specific time points. Consequently, tracking temporal changes in an infection within same individual is challenging. InVivo imaging techniques enable longitudinal assessment while reducing number animals required. Understanding dynamics over crucial for elucidating disease mechanisms and developing effective treatment strategies. In this review, we summarize Vivo used to detect colonization deep tissues infection, along with efforts enhance their sensitivity. particular, introduce a recently developed system that employs near‐infrared luminescence achieve high sensitivity versatility. Furthermore, discuss strategies further improving its

Language: Английский

Deep‐Tissue In Vivo Imaging Using Bioluminescence in a Mouse Infection Model and the Path to High Sensitivity With Near‐Infrared Luminescence DOI

Daiki Yamaguchi,

Kenji Oki,

Yuki Kaya

et al.

Microbiology and Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

ABSTRACT The analysis of bacterial infections using animal models has primarily relied on the average evaluation many individuals at specific time points. Consequently, tracking temporal changes in an infection within same individual is challenging. InVivo imaging techniques enable longitudinal assessment while reducing number animals required. Understanding dynamics over crucial for elucidating disease mechanisms and developing effective treatment strategies. In this review, we summarize Vivo used to detect colonization deep tissues infection, along with efforts enhance their sensitivity. particular, introduce a recently developed system that employs near‐infrared luminescence achieve high sensitivity versatility. Furthermore, discuss strategies further improving its

Language: Английский

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