Activity of Antiseptics Against Pseudomonas aeruginosa and Its Adaptation Potential DOI Creative Commons
Tomasz M. Karpiński,

Marzena Korbecka-Paczkowska,

Mark Stasiewicz

et al.

Antibiotics, Journal Year: 2025, Volume and Issue: 14(1), P. 30 - 30

Published: Jan. 3, 2025

Background/Objectives: Pseudomonas aeruginosa rapidly acquires antibiotic resistance and demonstrates increasing tolerance to antiseptics. This study evaluated the activity of eight antiseptics against P. aeruginosa, assessed its ability develop adaptation these antiseptics, and, for first time, determined Karpinski Adaptation Index (KAI) this bacterium. Methods: The minimal inhibitory concentration (MIC), susceptibility antibiotics, bactericidal time according EN 1040:2005, potential, KAI strains were evaluated. Results: most effective based on MIC activity, octenidine dihydrochloride (OCT; mean 11.3 ± 4.5 µg/mL), polyhexamethylene biguanide (PHMB; 22.6 8.0 chlorhexidine digluconate (CHX; 26.6 14.4 µg/mL). Sodium hypochlorite (NaOCl) ethacridine lactate (ET) showed moderate while boric acid (BA), povidone-iodine (PVI), potassium permanganate (KMnO4) exhibited weakest activity. values NaOCl (95 15.4 µg/mL) KMnO4 (>10 mg/mL) close or exceeded clinical concentrations used in commercial products. OCT, CHX, PVI fastest effect within 1 min. Bactericidal times up 15 min PHMB, 60 ET, more than BA, NaOCl, KMnO4. lowest values, indicating a low risk, observed OCT (0.12), PHMB (0.19), BA (0.19). Moderate risk was noted (0.21), CHX (0.29), ET (0.47). highest signifying very high found (1.0) (≥1.0). Conclusions: Antiseptics like partially can be critical quick antibacterial action infected wounds, agents such as might reserved cases where prolonged contact are possible. Given rapid currently use, reconsideration their effectiveness treating skin mucous membrane infections is recommended.

Language: Английский

Activity of Antiseptics Against Pseudomonas aeruginosa and Its Adaptation Potential DOI Creative Commons
Tomasz M. Karpiński,

Marzena Korbecka-Paczkowska,

Mark Stasiewicz

et al.

Antibiotics, Journal Year: 2025, Volume and Issue: 14(1), P. 30 - 30

Published: Jan. 3, 2025

Background/Objectives: Pseudomonas aeruginosa rapidly acquires antibiotic resistance and demonstrates increasing tolerance to antiseptics. This study evaluated the activity of eight antiseptics against P. aeruginosa, assessed its ability develop adaptation these antiseptics, and, for first time, determined Karpinski Adaptation Index (KAI) this bacterium. Methods: The minimal inhibitory concentration (MIC), susceptibility antibiotics, bactericidal time according EN 1040:2005, potential, KAI strains were evaluated. Results: most effective based on MIC activity, octenidine dihydrochloride (OCT; mean 11.3 ± 4.5 µg/mL), polyhexamethylene biguanide (PHMB; 22.6 8.0 chlorhexidine digluconate (CHX; 26.6 14.4 µg/mL). Sodium hypochlorite (NaOCl) ethacridine lactate (ET) showed moderate while boric acid (BA), povidone-iodine (PVI), potassium permanganate (KMnO4) exhibited weakest activity. values NaOCl (95 15.4 µg/mL) KMnO4 (>10 mg/mL) close or exceeded clinical concentrations used in commercial products. OCT, CHX, PVI fastest effect within 1 min. Bactericidal times up 15 min PHMB, 60 ET, more than BA, NaOCl, KMnO4. lowest values, indicating a low risk, observed OCT (0.12), PHMB (0.19), BA (0.19). Moderate risk was noted (0.21), CHX (0.29), ET (0.47). highest signifying very high found (1.0) (≥1.0). Conclusions: Antiseptics like partially can be critical quick antibacterial action infected wounds, agents such as might reserved cases where prolonged contact are possible. Given rapid currently use, reconsideration their effectiveness treating skin mucous membrane infections is recommended.

Language: Английский

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