Regulation of Histone Acetylation Modification on Biosynthesis of Secondary Metabolites in Fungi DOI Open Access

Xuwen Hou,

Liyao Liu,

Yu Li

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 26(1), P. 25 - 25

Published: Dec. 24, 2024

The histone acetylation modification is a conservative post-translational epigenetic regulation in fungi. It includes and deacetylation at the lysine residues of histone, which are catalyzed by acetyltransferase (HAT) deacetylase (HDAC), respectively. plays crucial roles fungal growth development, environmental stress response, secondary metabolite (SM) biosynthesis, pathogenicity. One most important to regulate gene expression that responsible for SM biosynthesis This mini-review summarized HATs HDACs on SMs In cases, positively regulated SMs, while had their negative regulations. Some were revealed biosynthesis. Hda1 was found be efficient regulator affect species mainly from genera Aspergillus, Calcarisporium, Cladosporium, Fusarium, Monascus, Penicillium, Pestalotiopsis. With strategy modification, some harmful will inhibited, production useful bioactive promoted subsequent research should focus study regulatory mechanisms.

Language: Английский

Consistency of gene expression and protein acetylation modification with physiological and biochemical changes responding to the deficiency of histone deacetylase 1 homolog in Monascus ruber DOI

Fufang Tang,

Yuehan Zhao,

Zejing Mao

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142485 - 142485

Published: April 1, 2025

Language: Английский

Citations

0
Regulation of Histone Acetylation Modification on Biosynthesis of Secondary Metabolites in Fungi DOI Open Access

Xuwen Hou,

Liyao Liu,

Yu Li

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 26(1), P. 25 - 25

Published: Dec. 24, 2024

The histone acetylation modification is a conservative post-translational epigenetic regulation in fungi. It includes and deacetylation at the lysine residues of histone, which are catalyzed by acetyltransferase (HAT) deacetylase (HDAC), respectively. plays crucial roles fungal growth development, environmental stress response, secondary metabolite (SM) biosynthesis, pathogenicity. One most important to regulate gene expression that responsible for SM biosynthesis This mini-review summarized HATs HDACs on SMs In cases, positively regulated SMs, while had their negative regulations. Some were revealed biosynthesis. Hda1 was found be efficient regulator affect species mainly from genera Aspergillus, Calcarisporium, Cladosporium, Fusarium, Monascus, Penicillium, Pestalotiopsis. With strategy modification, some harmful will inhibited, production useful bioactive promoted subsequent research should focus study regulatory mechanisms.

Language: Английский

Citations

2