Liver transcriptome response to avian pathogenic Escherichia coli infection in broilers with corticosterone treatment DOI Creative Commons

Mengru Chen,

Yifei He,

Yimin Jia

et al.

Poultry Science, Journal Year: 2025, Volume and Issue: 104(5), P. 105020 - 105020

Published: March 11, 2025

Avian pathogenic Escherichia coli (APEC) infection has high morbidity and mortality, multiple stressors encountered during rearing place poultry in a state of stress. However, research on how cope with APEC under stress situation is still limited. In this study, we established broiler model by corticosterone (CORT) administration subcutaneously for 7 consecutive days, followed challenge intramuscularly. CORT treatment significantly reduced body weight (BW) average daily gain (ADG) while increasing feed conversion ratio (FCR) (P < 0.01). decreased ADG elevated plasma heterophil to lymphocyte (H/L) 0.05). Additionally, aspartate aminotransferase (AST), AST alanine (AST/ALT) ratio, lactate dehydrogenase (LDH) levels increased Histopathological analysis revealed structural damage liver, indicating that induced liver injury. pretreatment broilers exhibited milder histopathological lesions lower AST, ALT, LDH 0.05) compared alone. lysozyme (LZM), total protein (TP), globulin (GLOB) 0.05), further elevating their concentrations alone, suggesting an enhanced innate immune response. Liver transcriptomic identified 768, 335, 567 differentially expressed genes (DEGs) following CORT, APEC, or both treatments, respectively, enriched cytokine-cytokine receptor interaction, PPAR signaling pathway, Toll-like MAPK steroid hormone biosynthesis arachidonic acid metabolism, phagosome etc., regulates lipid metabolism immunity, induces inflammation disrupts metabolism. Notably, may mitigate injury enhancing function. Moreover, glucocorticoid (GR) regulate DEGs expressions, thus affected response treatments. These results suggest treatment, infection, affect the growth performance, function broilers, play crucial role.

Language: Английский

Characterization and functional analysis of the small heat shock protein HSP19.5 in Bombyx mori in response to Nosema bombycis infection DOI

Zhenghao Han,

Shidong Jiang,

Jingxian Xie

et al.

Journal of Invertebrate Pathology, Journal Year: 2025, Volume and Issue: 210, P. 108289 - 108289

Published: Feb. 22, 2025

Language: Английский

Citations

0
Promotional activity of an uncharacterized protein Bm0979 on Nosema bombycis in silkworm, bombyx mori DOI

Yujia Fang,

Qiong Yu,

Wenzhe Chen

et al.

Journal of Asia-Pacific Entomology, Journal Year: 2025, Volume and Issue: unknown, P. 102389 - 102389

Published: Feb. 1, 2025

Language: Английский

Citations

0
Nosema bombycis: A remarkable unicellular parasite infecting insects DOI
Qingyuan Huang, Wanying Hu, Xianzhi Meng

et al.

Journal of Eukaryotic Microbiology, Journal Year: 2024, Volume and Issue: 71(5)

Published: Aug. 2, 2024

Abstract Microsporidia are opportunistic fungal‐like pathogens that cause microsporidiosis, which results in significant economic losses and threatens public health. Infection of domesticated silkworms by the microsporidium Nosema bombycis causes pébrine disease, for this species microsporidia has received much attention. Research been conducted extensively on over past few decades to better understand its infection, transmission, host–parasite interaction, detection. Several tools exist study including complete genome sequence N. . In addition understanding being important silkworm industry, become a model organism studying microsporidia. biology will contribute development knowledge regarding potential antimicrosporidia drugs. Furthermore, provide insight into molecular evolution functioning other fungal pathogens.

Language: Английский

Citations

3
Liver transcriptome response to avian pathogenic Escherichia coli infection in broilers with corticosterone treatment DOI Creative Commons

Mengru Chen,

Yifei He,

Yimin Jia

et al.

Poultry Science, Journal Year: 2025, Volume and Issue: 104(5), P. 105020 - 105020

Published: March 11, 2025

Avian pathogenic Escherichia coli (APEC) infection has high morbidity and mortality, multiple stressors encountered during rearing place poultry in a state of stress. However, research on how cope with APEC under stress situation is still limited. In this study, we established broiler model by corticosterone (CORT) administration subcutaneously for 7 consecutive days, followed challenge intramuscularly. CORT treatment significantly reduced body weight (BW) average daily gain (ADG) while increasing feed conversion ratio (FCR) (P < 0.01). decreased ADG elevated plasma heterophil to lymphocyte (H/L) 0.05). Additionally, aspartate aminotransferase (AST), AST alanine (AST/ALT) ratio, lactate dehydrogenase (LDH) levels increased Histopathological analysis revealed structural damage liver, indicating that induced liver injury. pretreatment broilers exhibited milder histopathological lesions lower AST, ALT, LDH 0.05) compared alone. lysozyme (LZM), total protein (TP), globulin (GLOB) 0.05), further elevating their concentrations alone, suggesting an enhanced innate immune response. Liver transcriptomic identified 768, 335, 567 differentially expressed genes (DEGs) following CORT, APEC, or both treatments, respectively, enriched cytokine-cytokine receptor interaction, PPAR signaling pathway, Toll-like MAPK steroid hormone biosynthesis arachidonic acid metabolism, phagosome etc., regulates lipid metabolism immunity, induces inflammation disrupts metabolism. Notably, may mitigate injury enhancing function. Moreover, glucocorticoid (GR) regulate DEGs expressions, thus affected response treatments. These results suggest treatment, infection, affect the growth performance, function broilers, play crucial role.

Language: Английский

Citations

0