Application and potential therapeutic effect of endolysin Lys1472 against Clostridium perfringens in chicken meat

LWT, Journal Year: 2025, Volume and Issue: unknown, P. 117332 - 117332

Published: Jan. 1, 2025

Language: Английский

Isolation of phages infecting the zoonotic pathogen Streptococcus suis reveals novel structural and genomic characteristics

Microbiological Research, Journal Year: 2025, Volume and Issue: unknown, P. 128147 - 128147

Published: March 1, 2025

Bacteriophage research has experienced a renaissance in recent years, owing to their therapeutic potential and versatility biotechnology, particularly combating antibiotic resistant-bacteria along the farm-to-fork continuum. However, certain pathogens remain underexplored as targets for phage therapy, including zoonotic pathogen Streptococcus suis which causes infections pigs humans. Despite global efforts, genome of only one infective S. been described. Here, we report isolation two phages that infect suis: Bonnie Clyde. The 58 100 strains tested, representatives seven different serotypes thirteen known sequence types from diverse geographical origins. Clyde suppressed bacterial growth vitro within multi-strain mixes designed simulate polyclonal infection. Both demonstrated stability across various temperatures pH levels, highlighting withstand storage conditions maintain viability delivery formulations. Genome comparisons revealed neither shares significant nucleotide identity with any cultivated NCBI database thereby represent novel species belonging distinct genera. This study is first investigate adhesion devices infecting phages. Structure prediction analysis AlphaFold2 lineages phages: thermophilus-like (Bonnie) suis-like (Clyde). structural similarities between thermophilus phages, despite lack similarity differing ecological niches, suggest common ancestor or convergent evolution, evolutionary links pathogenic non-pathogenic streptococcal species. These findings provide valuable insights into genetic phenotypic characteristics can suis, providing new data application One Health context.

Language: Английский

Reviving hope: Phage therapy application for antimicrobial resistance in farm animal production over the past decade

Animal Feed Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 116333 - 116333

Published: April 1, 2025

Language: Английский