Combined Administration of Metformin and Amprolium to Rats Affects Metabolism of Free Amino Acids in the Brain, Altering Behavior, and Heart Rate DOI
А. В. Граф, Artem V. Artiukhov, Olga N. Solovjeva

et al.

Biochemistry (Moscow), Journal Year: 2024, Volume and Issue: 89(10), P. 1692 - 1710

Published: Oct. 1, 2024

Language: Английский

BIOCHEMICAL AND MEDICAL ASPECTS OF VITAMIN B1 RESEARCH DOI

Alexander F Makarchikov,

Pierre Wins,

Lucien Bettendorff

et al.

Neurochemistry International, Journal Year: 2025, Volume and Issue: unknown, P. 105962 - 105962

Published: March 1, 2025

Language: Английский

Citations

0
A cross-sectional survey on the health status of patients with Charcot–Marie–Tooth disease in a Chinese national patient group DOI
Shimiao Dai, Jiayin Zheng, Yuqing Chen

et al.

Journal of Neurology, Journal Year: 2025, Volume and Issue: 272(5)

Published: April 8, 2025

Language: Английский

Citations

0
Thiamine, gastrointestinal beriberi and acetylcholine signaling DOI Creative Commons
Edgar T. Overton,

Alina Emelyanova,

Victoria I. Bunik

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: April 9, 2025

Research has highlighted numerous detrimental consequences of thiamine deficiency on digestive function. These range from impaired gastric and intestinal motility to aberrant changes in pancreatic exocrine function, acidity disturbances gut barrier integrity inflammation. Thiamine its pharmacological forms, as a primary or adjunctive therapy, have been shown improve symptoms such nausea, constipation, dysphagia dysmotility, both humans animals. This review aims explore molecular mechanisms underlying the therapeutic action gastrointestinal dysfunction. Our analysis demonstrates that insufficiency restricted system, i.e., lacking well-known dry wet beriberi, may arise through (i) disbalance between nutrient influx efflux system due increased demands by organism; (ii) direct exposure oral drugs microbiome, targeting thiamine-dependent metabolism first line; (iii) involvement acetylcholine (ACh) signaling cholinergic activity enteric nervous non-neuronal cells pancreas, employing coenzyme non-coenzyme actions thiamine. The relies requirement form - diphosphate for production energy (ACh). involves participation and/or derivatives, including triphosphate, regulation ACh synaptic consistent with early data co-mediator neuromuscular synapses, allosteric metabolic enzymes. By examining available evidence focus we deepen understanding thiamine's contribution overall health, highlighting important implications functional disorders.

Language: Английский

Citations

0
A challenging interplay between basic research, technologies and medical education to provide therapies based on disease mechanisms DOI Creative Commons
Victoria I. Bunik

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Aug. 20, 2024

A challenging interplay between basic research, technologies and medical education to provide therapies based on disease mechanisms

Language: Английский

Citations

1
Combined Administration of Metformin and Amprolium to Rats Affects Metabolism of Free Amino Acids in the Brain, Altering Behavior, and Heart Rate DOI
А. В. Граф, Artem V. Artiukhov, Olga N. Solovjeva

et al.

Biochemistry (Moscow), Journal Year: 2024, Volume and Issue: 89(10), P. 1692 - 1710

Published: Oct. 1, 2024

Language: Английский

Citations

0