Targeting Lysosomal Dysfunction and Oxidative Stress in Age-Related Macular Degeneration
Ana S. Falcão,
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M. Del Pedro,
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Sandra Tenreiro
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et al.
Antioxidants,
Journal Year:
2025,
Volume and Issue:
14(5), P. 596 - 596
Published: May 16, 2025
Age-related
macular
degeneration
(AMD)
is
the
leading
cause
of
vision
loss
in
Western
world,
and
it
currently
lacks
effective
therapy.
It
believed
that
AMD
initiates
aged
retinal
pigment
epithelium
(RPE),
which
presents
lysosomal
dysfunction
oxidative
stress
(OxS)
ultimately
leads
to
RPE
damage
progression.
a
complex
pathology,
so
multitarget
treatments
are
required
act
on
different
pathways,
presenting
several
challenges.
In
this
review,
we
discuss
current
knowledge
pathogenesis
disease,
focusing
mainly
OxS.
Because
transcription
factors
regulate
homeostasis,
factor
EB
(TFEB),
controls
function
biogenesis,
nuclear
erythroid
2-related
2
(NRF2),
manages
OxS,
have
been
proposed
as
promising
targets
for
disease
intervention.
Finally,
interplay
these
pathways
potential
synergistic
effect
AMD-targeted
therapies,
they
could
change
course
today’s
available
AMD.
Language: Английский
Recent Achievements in the Heterogeneity of Mammalian and Human Retinal Pigment Epithelium: In Search of a Stem Cell
Cells,
Journal Year:
2024,
Volume and Issue:
13(3), P. 281 - 281
Published: Feb. 4, 2024
Retinal
pigment
epithelium
(RPE)
cells
are
important
fundamentally
for
the
development
and
function
of
retina.
In
this
regard,
study
morphological
molecular
properties
RPE
cells,
as
well
their
regenerative
capabilities,
is
particular
importance
biomedicine.
However,
these
studies
complicated
by
fact
that,
despite
external
similarity
a
population
heterogeneous
genetic
which
have
begun
to
be
revealed
sequencing
methods
only
in
recent
years.
This
review
carries
out
an
analysis
data
from
heterogeneity
mammals
humans,
reveals
individual
differences
subpopulations
possible
specificity
functions.
Particular
attention
paid
discussing
"stemness,"
proliferation,
plasticity
RPE,
may
useful
uncovering
mechanisms
retinal
diseases
associated
with
pathologies
finding
new
ways
treating
them.
Language: Английский
Cellular and Molecular Triggers of Retinal Regeneration in Amphibians
Life,
Journal Year:
2023,
Volume and Issue:
13(10), P. 1981 - 1981
Published: Sept. 28, 2023
Understanding
the
mechanisms
triggering
initiation
of
retinal
regeneration
in
amphibians
may
advance
quest
for
prevention
and
treatment
options
degenerating
human
retina
diseases.
Natural
requires
two
cell
sources,
namely
pigment
epithelium
(RPE)
ciliary
marginal
zone.
The
disruption
RPE
interaction
with
photoreceptors
through
surgery
or
injury
triggers
local
systemic
responses
protection.
In
mammals,
disease-induced
damage
to
results
shutdown
function,
cellular
oxidative
stress,
pronounced
immune
response,
death
degeneration.
contrast
pathology
regenerative
have
taxon-specific
features
ensuring
efficient
regeneration.
These
include
rapid
hemostasis,
recruitment
cells
factors
endogenous
defense
systems,
activities
immature
system,
high
viability,
efficiency
extracellular
matrix,
cytoskeleton,
surface
remodeling.
reactions
are
controlled
by
specific
signaling
pathways,
transcription
factors,
epigenome,
which
insufficiently
studied.
This
review
provides
a
summary
initiating
reveals
its
collectively
directed
at
recruiting
universal
trauma
activate
sources
study
integrated
molecular
network
these
processes
is
prospect
future
research
demand
biomedicine.
Language: Английский