Dynamics of blood adipokine levels and their ratios in assisted reproductive technology programs depending on the clinical pregnancy onset DOI
Julian R. Ryzhov, Manizha R. Makhmadalieva, Elena A. Lesik

et al.

Journal of obstetrics and women s diseases, Journal Year: 2024, Volume and Issue: 73(5), P. 84 - 95

Published: Dec. 4, 2024

BACKGROUND: The adipokines leptin, adiponectin, and ghrelin are expressed not only in adipose tissue but also the hypothalamic-pituitary-gonadal axis organs uterus. They regulate gonadotropin-releasing hormone gonadotropin secretion, steroidogenesis, folliculogenesis, implantation, serve as promising markers of assisted reproductive technology program outcomes. AIM: aim this study was to evaluate dynamics blood adipokine levels their ratios during controlled ovarian hyperstimulation programs depending on onset clinical pregnancy. MATERIALS AND METHODS: This involved 51 patients undergoing infertility treatment using a short protocol with antagonists. Depending pregnancy, two groups were formed: non-pregnant (group 1, n = 22) pregnant 2, 29). Blood assessed enzyme immunoassay at three points: start-up, day oocyte pick-up, embryo transfer. RESULTS: On group 1 had higher leptin (5.47 ± 1.92 vs. 3.76 0.75 ng/ml; p 0.0004), leptin/adiponectin (11.45 4.50 4.73 1.08; 0.001), leptin/ghrelin (0.43 0.17 0.24 0.07; 0.001). transfer, (6.37 2.13 3.29 1.21 0.001) adiponectin (0.75 0.22 0.60 0.09 well (9.06 3.73 5.59 2.32; (0.48 0.15 0.20 adiponectin/ghrelin (0.06 0.02 0.04 0.01; CONCLUSIONS: data obtained indicate that change protocols pregnancy can be used predict its onset.

Language: Английский

Leptin Fragment Modulates Stimulatory Effects of Chorionic Gonadotropin on Testicular Steroidogenesis in a Rat Model of Diet-Induced Obesity DOI
A. A. Bakhtyukov, I. A. Lebedev, I. Yu. Morina

et al.

Journal of Evolutionary Biochemistry and Physiology, Journal Year: 2024, Volume and Issue: 60(2), P. 504 - 514

Published: March 1, 2024

Language: Английский

Citations

0
Leptin fragment modulates the stimulatory effects of chorionic gonadotropin on testicular steroidogenesis in a model of diet-induced obesity in rats DOI
A. A. Bakhtyukov, I. A. Lebedev, I. Yu. Morina

et al.

Журнал эволюционной биохимии и физиологии, Journal Year: 2024, Volume and Issue: 60(3), P. 223 - 233

Published: Nov. 16, 2024

Language: Английский

Citations

0
Dynamics of blood adipokine levels and their ratios in assisted reproductive technology programs depending on the clinical pregnancy onset DOI
Julian R. Ryzhov, Manizha R. Makhmadalieva, Elena A. Lesik

et al.

Journal of obstetrics and women s diseases, Journal Year: 2024, Volume and Issue: 73(5), P. 84 - 95

Published: Dec. 4, 2024

BACKGROUND: The adipokines leptin, adiponectin, and ghrelin are expressed not only in adipose tissue but also the hypothalamic-pituitary-gonadal axis organs uterus. They regulate gonadotropin-releasing hormone gonadotropin secretion, steroidogenesis, folliculogenesis, implantation, serve as promising markers of assisted reproductive technology program outcomes. AIM: aim this study was to evaluate dynamics blood adipokine levels their ratios during controlled ovarian hyperstimulation programs depending on onset clinical pregnancy. MATERIALS AND METHODS: This involved 51 patients undergoing infertility treatment using a short protocol with antagonists. Depending pregnancy, two groups were formed: non-pregnant (group 1, n = 22) pregnant 2, 29). Blood assessed enzyme immunoassay at three points: start-up, day oocyte pick-up, embryo transfer. RESULTS: On group 1 had higher leptin (5.47 ± 1.92 vs. 3.76 0.75 ng/ml; p 0.0004), leptin/adiponectin (11.45 4.50 4.73 1.08; 0.001), leptin/ghrelin (0.43 0.17 0.24 0.07; 0.001). transfer, (6.37 2.13 3.29 1.21 0.001) adiponectin (0.75 0.22 0.60 0.09 well (9.06 3.73 5.59 2.32; (0.48 0.15 0.20 adiponectin/ghrelin (0.06 0.02 0.04 0.01; CONCLUSIONS: data obtained indicate that change protocols pregnancy can be used predict its onset.

Language: Английский

Citations

0