The Role of DNA Methylation in Zebrafish Models of CNS Diseases DOI

L. V. Yushko,

A. D. Shevlyakov,

M. A. Romazeva

et al.

Российский физиологический журнал им  И  М  Сеченова, Journal Year: 2024, Volume and Issue: 110(5), P. 661 - 679

Published: Oct. 19, 2024

DNA methylation plays an important role in the regulation of gene expression. Disturbances this process brain cause various neurological diseases, including autism, schizophrenia and mood disorders. Zebrafish (Danio rerio) are a promising model organism biomedicine. Given high genetic physiological homology with humans, studying genome deficits zebrafish can help to clarify molecular processes underlying etiology pathogenesis as well develop novel therapies. Here, we discuss mechanisms diseases associated its dysregulation their pharmacological models zebrafish. We also evaluate limitations possible directions for further research field. Mounting evidence summarized here supports effective elucidating pathologies impaired methylation.

Language: Английский

Animal Models of Febrile Seizures: Limitations and Recent Advances in the Field DOI Creative Commons

Alexandra V. Griflyuk,

Tatyana Y. Postnikova, Aleksey V. Zaitsev

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(22), P. 1895 - 1895

Published: Nov. 16, 2024

Febrile seizures (FSs) are defined as occurring in children aged 6 months to 5 years with a background of elevated body temperature. It is one the most common neurological disorders childhood, emphasizing importance understanding causes FSs and their impact on developing nervous system. However, there significant limitations technologies currently available for studying etiology pathophysiology humans. not possible adequately capture subtle molecular structural rearrangements system that can occur after The use animal models be invaluable these purposes. commonly used modern research hyperthermic rats mice 10-12 days. While reproduce many characteristics FSs, they have certain limitations. This review outlines key considerations when working provides an overview current approaches producing different model subjects, presents summary findings regarding morphological functional changes brain behavioral alterations been identified studies using FSs.

Language: Английский

Citations

3
The Role of DNA Methylation in Zebrafish Models of CNS Diseases DOI Creative Commons

L. V. Yushko,

A. D. Shevlyakov,

M. A. Romazeva

et al.

Journal of Evolutionary Biochemistry and Physiology, Journal Year: 2024, Volume and Issue: 60(3), P. 973 - 987

Published: May 1, 2024

Abstract DNA methylation plays an important role in the regulation of gene expression. Its deficits brain cause various neurological diseases, including autism, schizophrenia and mood disorders. The zebrafish ( Danio rerio ) is a promising model organism biomedicine. Given its high genetic physiological homology with humans, studying genome can help elucidate molecular processes underlying etiology pathogenesis as well develop novel therapies. Here, we discuss mechanisms diseases associated dysregulation their pharmacological models zebrafish. We also evaluate limitations possible directions for further research this field. Mounting evidence summarized here supports effective elucidating pathologies compromised methylation.

Language: Английский

Citations

0
The Role of DNA Methylation in Zebrafish Models of CNS Diseases DOI

L. V. Yushko,

A. D. Shevlyakov,

M. A. Romazeva

et al.

Российский физиологический журнал им  И  М  Сеченова, Journal Year: 2024, Volume and Issue: 110(5), P. 661 - 679

Published: Oct. 19, 2024

DNA methylation plays an important role in the regulation of gene expression. Disturbances this process brain cause various neurological diseases, including autism, schizophrenia and mood disorders. Zebrafish (Danio rerio) are a promising model organism biomedicine. Given high genetic physiological homology with humans, studying genome deficits zebrafish can help to clarify molecular processes underlying etiology pathogenesis as well develop novel therapies. Here, we discuss mechanisms diseases associated its dysregulation their pharmacological models zebrafish. We also evaluate limitations possible directions for further research field. Mounting evidence summarized here supports effective elucidating pathologies impaired methylation.

Language: Английский

Citations

0