Mononuclear Copper(II) Phosphinates Bearing Mono‐, Bi‐, and Tridentate N‐Donor Ligands: DNA Binding and Cleavage, Cytotoxicity, and Nanoencapsulation

Chemistry - An Asian Journal, Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

Abstract Mononuclear Cu(II) phosphinate‐based compounds, [Cu(H 2 L 1 ) (Py) ] (1) , [Cu(OAc)(H )(Cl‐tpy)] (2) and )(Phen) ]H (3) (Py = pyridine, Cl‐tpy 4ʹ‐chloro‐2,2ʹ:6ʹ,2ʹʹ‐terpyridine, Phen 1,10‐phenanthroline monohydrate) were synthesized by reacting Cu(OAc) ·2H O with N ‐donor ligands in the presence of bis(2‐hydroxy‐5‐methylphenyl) phosphinic acid (H 3 ). The compounds isolated as single crystals characterized spectroscopic microanalytical techniques. Owing to bioavailability biocompatibility copper, oxidative DNA cleavage ability – was studied incubating supercoiled (SC) pUC19 (40 µM). highest efficiency complex is attributed strong partial intercalation 1, 10‐phenanthroline rings, which enhances reactive oxygen species (ROS) generation. Encapsulation a polydiacetylene‐supported liposome nanocarrier (Lip‐(3)) improves anticancer activity while addressing solubility toxicity concerns. spherical nanoparticles (∼93 nm), UV–vis, TEM, DLS, EDX studies exhibit stability, efficient encapsulation, suitability for targeted drug delivery.

Language: Английский

Photoinduced cytotoxic activity of a rare ruthenium nitrosyl phenanthroline complex showing NO generation in human cells

Dalton Transactions, Journal Year: 2024, Volume and Issue: 53(43), P. 17642 - 17653

Published: Jan. 1, 2024

The article is devoted to the investigation of photochemical and biological properties [RuNO(Phen)(NO 2 ) OH] complex, such as crystal structure, quantum yield photolysis reaction well cytotoxicity towards cell line MCF-7, A549 MRC5.

Language: Английский