Applied Organometallic Chemistry, Journal Year: 2025, Volume and Issue: 39(3)
Published: Feb. 5, 2025
ABSTRACT A novel Schiff base ligand derived from 1,2,4‐triazole‐3‐thione was synthesized and complexed with platinum (IV) ion to enhance its bioactivity. Characterization techniques, including FTIR, NMR, UV‐Vis, mass spectrometry, confirmed the formation of molecule revealed that Pt(IV) complex has an octahedral geometry. The antibacterial antifungal activity compounds evaluated against Staphylococcus epidermidis , Pseudomonas aeruginosa Candida albicans Aspergillus flavus metal outperforming ligand. antioxidant properties were using a DPPH assay, demonstrating superior radical‐scavenging ability. Cytotoxicity studies via MTT assays on MCF‐7 breast cancer cells showed dose‐dependent reductions in cell viability, inducing enhanced antiproliferative effects compared DFT calculations performed investigate electronic compounds, molecular docking conducted alpha estrogen receptor (PDB ID: 3ERT) predict their binding affinities. results demonstrated exhibited higher biological than free ligand, suggesting potential as effective therapeutic agent.
Language: Английский