Chemoselective Cleavage and Transamidation of Tertiary p-Methoxybenzyl Amides under Metal-Free Photoredox Catalysis DOI

Hee-Chan Jeong,

Hyo‐Jun Lee, Keiji Maruoka

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 21, 2024

A metal-free and mild cleavage of tertiary

Language: Английский

Solvent solute interaction (IEFPCM model), Michael addition-based anticancer drug synthesis, FTIR, NMR, and UV–visible investigations of spirooxindole-pyranoindole (2AIPC) − in vitro and in silico anti-cancer activity DOI
P. Manikandan, Mohit Kumar,

P. Swarnamughi

et al.

Journal of Molecular Liquids, Journal Year: 2024, Volume and Issue: 405, P. 125064 - 125064

Published: May 19, 2024

Language: Английский

Citations

10
Recent Advances in Aggregation-Induced Emission Bioconjugates DOI
Guiquan Zhang,

Daming Zhou,

Rong Hu

et al.

Bioconjugate Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Fluorescence imaging technology is playing increasing roles in modern personalized and precision medicine. Thanks to their excellent photophysical properties, organic luminogens featuring aggregation-induced emission (AIE) characteristics (AIEgens) have attracted considerable attention over the past two decades. Because of superior biocompatibility, ease processing functionalization, water solubility, high responsiveness, exceptional signal-to-noise ratio (SNR) for biotargets, AIE bioconjugates, formed by covalently linking AIEgens with biomolecules, emerged as an ideal candidate bioapplications. In this review, we summarize progress preparation, application bioconjugates last five years. Moreover, challenges opportunities are also briefly discussed.

Language: Английский

Citations

0
Synthesis of highly functionalized imine-containing halogen-substituted-1-oxo-acenaphthenes and their quantum computational investigation as propitious drugs for anti-skin cancer DOI
Aslı Eşme, Abul Hasnat,

Nuzhat Bashir

et al.

Journal of Molecular Liquids, Journal Year: 2024, Volume and Issue: 415, P. 126402 - 126402

Published: Nov. 1, 2024

Language: Английский

Citations

1
Novel Amidine Derivative K1586 Sensitizes Colorectal Cancer Cells to Ionizing Radiation by Inducing Chk1 Instability DOI Open Access

Hang Soo Kim,

Ji Eun Park,

Won Hyung Lee

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(8), P. 4396 - 4396

Published: April 16, 2024

Checkpoint kinase 1 (Chk1) is a key mediator of the DNA damage response that regulates cell cycle progression, repair, and replication. Small-molecule Chk1 inhibitors sensitize cancer cells to genotoxic agents have shown preclinical activity as single in cancers characterized by high levels replication stress. However, underlying genetic determinants Chk1-inhibitor sensitivity remain unclear. Although treatment options for advanced colorectal are limited, radiotherapy effective. Here, we report exposure novel amidine derivative, K1586, leads an initial reduction proliferative potential cells. Cell analysis revealed length G2/M phase increased with K1586 result instability. Exposure enhanced degradation time- dose-dependent manner, increasing stress sensitizing radiation. Taken together, results suggest derivative may radiotherapy-sensitization agent targets Chk1.

Language: Английский

Citations

0
Copper-catalyzed time-dependent easy transformation of aryl/heteroaryl aldehyde into cyano and amide derivatives using ammonium acetate/iodine DOI
Sumit Kumar,

Neeru Bhanwala,

Jatin Malik

et al.

Research on Chemical Intermediates, Journal Year: 2024, Volume and Issue: 50(9), P. 4387 - 4405

Published: July 27, 2024

Language: Английский

Citations

0
Chemoselective Cleavage and Transamidation of Tertiary p-Methoxybenzyl Amides under Metal-Free Photoredox Catalysis DOI

Hee-Chan Jeong,

Hyo‐Jun Lee, Keiji Maruoka

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 21, 2024

A metal-free and mild cleavage of tertiary

Language: Английский

Citations

0