The current landscape of 1,2,3‐triazole hybrids with anticancer therapeutic potential: Part I DOI
Shanshan Huang,

Zhi Xu,

Yafei Zhuang

et al.

Archiv der Pharmazie, Journal Year: 2025, Volume and Issue: 358(3)

Published: March 1, 2025

Abstract Cancer, with its steadily increasing morbidity and mortality, will continue to pose a threat humanity over an extended period. Chemotherapeutics play indispensable role in cancer treatment, hundreds of drugs have been approved for this purpose. Nevertheless, the fight against remains formidable challenge. This is mainly due emergence multidrug resistance severe side effects associated currently available anticancer drugs. Consequently, there urgent imperative explore novel chemotherapeutic agents. 1,2,3‐Triazoles belong one most privileged classes nitrogen‐containing five‐membered heterocycles are regarded as prominent sources development innovative chemotherapeutics. 1,2,3‐Triazole hybrids, which possess multitargeted mechanisms action within progression pathway, hold potential overcome mitigate effects. Furthermore, several 1,2,3‐triazole hybrids already therapy or under clinical evaluation. clearly demonstrates that valuable scaffolds treatment eradication cancer. review aims provide insights into therapeutic along their action, crucial aspects design, structure–activity relationships (SARs). It encompasses articles published from 2021 onward.

Language: Английский

The current landscape of 1,2,3‐triazole hybrids with anticancer therapeutic potential: Part I DOI
Shanshan Huang,

Zhi Xu,

Yafei Zhuang

et al.

Archiv der Pharmazie, Journal Year: 2025, Volume and Issue: 358(3)

Published: March 1, 2025

Abstract Cancer, with its steadily increasing morbidity and mortality, will continue to pose a threat humanity over an extended period. Chemotherapeutics play indispensable role in cancer treatment, hundreds of drugs have been approved for this purpose. Nevertheless, the fight against remains formidable challenge. This is mainly due emergence multidrug resistance severe side effects associated currently available anticancer drugs. Consequently, there urgent imperative explore novel chemotherapeutic agents. 1,2,3‐Triazoles belong one most privileged classes nitrogen‐containing five‐membered heterocycles are regarded as prominent sources development innovative chemotherapeutics. 1,2,3‐Triazole hybrids, which possess multitargeted mechanisms action within progression pathway, hold potential overcome mitigate effects. Furthermore, several 1,2,3‐triazole hybrids already therapy or under clinical evaluation. clearly demonstrates that valuable scaffolds treatment eradication cancer. review aims provide insights into therapeutic along their action, crucial aspects design, structure–activity relationships (SARs). It encompasses articles published from 2021 onward.

Language: Английский

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