Targeting myeloid differentiation protein 2 ameliorates rheumatoid arthritis by inhibiting inflammation and ferroptosis via MAPK and NF-κB signaling pathways DOI
Lirun Zhou, Tong Yang, Shujie Zhang

et al.

Journal of Molecular Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: May 21, 2025

Language: Английский

Exploring the mechanism and crosstalk between IL-6 and IL- 1β on M2 macrophages under metabolic stress conditions DOI

Shawna Yadav,

Anusha Prasannan,

Kaliyamurthi Venkatachalam

et al.

Cytokine, Journal Year: 2025, Volume and Issue: 186, P. 156852 - 156852

Published: Jan. 6, 2025

Language: Английский

Citations

1
Targeting macrophage polarization by inhibiting Pim2 alleviates inflammatory arthritis via metabolic reprogramming DOI Creative Commons
Xiaojun Xu, Peitao Xu, Guozhen Shen

et al.

Cellular and Molecular Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 26, 2025

Abstract Macrophage polarization and energy metabolic reprogramming play pivotal roles in the onset progression of inflammatory arthritis. Moreover, although previous studies have reported that proviral integration Moloney virus 2 (Pim2) kinase is involved various cancers through mediation aerobic glycolysis cancer cells, its role arthritis remains unclear. In this study, we demonstrated multiple enzymes are activated upon Pim2 upregulation during M1 macrophage polarization. Specifically, directly phosphorylates PGK1-S203, PDHA1-S300, PFKFB2-S466, thereby promoting glycolytic reprogramming. expression was elevated macrophages from patients with collagen-induced (CIA) model mice. Conditional knockout or administration inhibitor HJ-PI01 attenuated development by inhibiting Through molecular docking dynamic simulation, bexarotene identified as an inhibits downstream polarization, mitigating For targeted treatment, neutrophil membrane-coated (Bex)-loaded PLGA-based nanoparticles (NM@NP-Bex) were developed to slow suppressing macrophages, these (NPs) exhibited superior therapeutic effects fewer side effects. Taken together, results our study targeting inhibition could effectively alleviate via reversal M1/M2 imbalance. NM@NPs loaded represent a promising strategy for treatment

Language: Английский

Citations

1
Osteopontin in Chronic Inflammatory Diseases: Mechanisms, Biomarker Potential, and Therapeutic Strategies DOI Creative Commons

Fuyuan Lang,

Yuanheng Li,

Ruizhe Yao

et al.

Biology, Journal Year: 2025, Volume and Issue: 14(4), P. 428 - 428

Published: April 16, 2025

Chronic inflammatory diseases, such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), multiple sclerosis (MS), atherosclerosis, and bowel disease (IBD), pose major global health concerns. These disorders are marked by persistent inflammation, immune system dysfunction, tissue injury, fibrosis, ultimately leading to severe organ dysfunction diminished quality of life. Osteopontin (OPN), a multifunctional extracellular matrix protein, plays crucial role in regulation, remodeling. It promotes cell recruitment, stimulates pro-inflammatory cytokine production, contributes fibrosis through interactions with integrins CD44 receptors. Additionally, OPN activates key pathways, including NF-κB, MAPK, PI3K/Akt, further aggravating damage chronic conditions. Our review highlights the its potential biomarker, therapeutic implications. We explore promising preclinical approaches, monoclonal antibodies, small molecule inhibitors, natural compounds like curcumin, which have demonstrated mitigating OPN-driven inflammation. However, challenges persist selectively targeting while maintaining essential physiological roles, bone remodeling wound healing. offers insights into strategies future research directions.

Language: Английский

Citations

1
Advancements in rheumatoid arthritis therapy: a journey from conventional therapy to precision medicine via nanoparticles targeting immune cells DOI

Anwesha Laha,

Simran Nasra, Dhiraj Bhatia

et al.

Nanoscale, Journal Year: 2024, Volume and Issue: 16(32), P. 14975 - 14993

Published: Jan. 1, 2024

Rheumatoid arthritis (RA) is a progressive autoimmune disease that mainly affects the inner lining of synovial joints and leads to chronic inflammation. While RA not known as lethal, recent research indicates it may be silent killer because its strong association with an increased risk lung heart diseases. Patients develop these systemic consequences due regular uptake heavy drugs such disease-modifying antirheumatic medications (DMARDs), glucocorticoids (GCs), nonsteroidal anti-inflammatory medicines (NSAIDs),

Language: Английский

Citations

6
Evolution and trajectory of B-cell targeted therapies in rheumatic diseases DOI
L. M. Carter, Michael R. Ehrenstein, Edward M Vital

et al.

The Lancet Rheumatology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Mendelian Randomization Unveils a Causal Relationship Between Inflammation, Metabolism, and Systemic Sclerosis DOI Creative Commons
Yuanyuan Zeng, Wen Zeng, Zhipeng Li

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

Abstract Background Inflammatory processes and metabolic activity significantly influence the beginning course of systemic sclerosis (SSc). This study aims to explore genetic basis for impact inflammation metabolism on susceptibility SSc. Methods We used three types exposure: 91 inflammatory proteins (14,824 participants), 731 immune cell traits (3,757 Sardinians), 1,400 blood metabolites (8,299 Europeans), with SSc as an outcome (680 cases, 399,355 controls). A two-sample multivariate bivariate Mendelian randomization (MR) was conducted investigate causal relationship between inflammation, metabolism, interaction proteins, cells, in Results MR analysis identified potential associations four fourteen a significant association two cells Among them, HLA DR CD14- CD16+ monocyte CD33dim DR+ CD11b+ reduced risk Pleiotropy heterogeneity were not observed. None showed bidirectional causality reverse analysis. Multivariate results independent effects one cell, SSc; factors (hepatocyte growth factor, stem 5-hydroxyindole sulfate levels); protective (HLA monocyte, Homoarginine levels Tetradecadienoate (14:2) levels). Conclusions These findings reveal relationships interactions fifteen traits, its development, offering fresh perspectives mechanisms underlying guiding choice treatment approaches.

Language: Английский

Citations

0
The C-reactive protein (CRP)-albumin-lymphocyte (CALLY) index exhibits an L-shaped association with all-cause mortality in rheumatoid arthritis patients: a retrospective cohort study DOI Creative Commons
Jialin Zhang,

Yanhua Lin,

Jingyan Zeng

et al.

BMC Rheumatology, Journal Year: 2025, Volume and Issue: 9(1)

Published: April 22, 2025

Language: Английский

Citations

0
PD1+ innate lymphoid cells 3 predict JAK-dependent inflammation in rheumatoid arthritis DOI Creative Commons
Aditya Arra, Katrin Vogel,

I. Han

et al.

Journal of Autoimmunity, Journal Year: 2025, Volume and Issue: 154, P. 103424 - 103424

Published: April 28, 2025

Language: Английский

Citations

0
Ghrelin/GHSR system attenuates collagen-induced arthritis in mice and ameliorates inflammation in human rheumatoid arthritis fibroblast-like synoviocytes DOI
Junxian Ma, Jinshan Zhang, Jie Liu

et al.

Biochemical Pharmacology, Journal Year: 2025, Volume and Issue: 238, P. 116973 - 116973

Published: May 6, 2025

Language: Английский

Citations

0
Targeting myeloid differentiation protein 2 ameliorates rheumatoid arthritis by inhibiting inflammation and ferroptosis via MAPK and NF-κB signaling pathways DOI
Lirun Zhou, Tong Yang, Shujie Zhang

et al.

Journal of Molecular Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: May 21, 2025

Language: Английский

Citations

0