Smoking negatively impacts ocular surface health and corneal nerve metrics DOI Creative Commons

Ansa Anam,

Mingyi Yu,

Chang Liu

et al.

The Ocular Surface, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

To evaluate the effects of smoking on ocular surface through comprehensive analysis corneal nerves, epithelium, dendritic cells (DCs), and clinical assessments. This cross-sectional study included 250 healthy smokers 272 non-smokers. Patients' status duration were recorded. In vivo confocal microscopy was performed to assess 7 quantitative nerves parameters, 3 neuroma DCs epithelial parameters. Ocular evaluations tear break-up time (TBUT), staining, sensitivity, Schirmer test. Surface Disease Index questionnaire used for symptom assessment. Compared non-smokers, exhibited significantly lower nerve fiber density (CNFD), branch density, length, total area (CNFA), fractal dimension (CFracDim; all p<0.001). Smokers also presented with a swollen (p<0.001). Longer associated CNFD (β=-0.04, P=0.010), CNFA (β=-0.00002, P=0.033), CFracDim (β=-0.0008, P=0.016). Additionally, larger (p=0.040), size (p<0.001) perimeter (p<0.001), as well higher count (p=0.003), elongation which suggested maturity observed in group. demonstrated staining scores reduced TBUT (p=0.001). Corneal circularity borderline subjects (p=0.059). Smoking is significant alterations morphology quantity, increased immunological cells, compromised integrity.

Language: Английский

Smoking negatively impacts ocular surface health and corneal nerve metrics DOI Creative Commons

Ansa Anam,

Mingyi Yu,

Chang Liu

et al.

The Ocular Surface, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

To evaluate the effects of smoking on ocular surface through comprehensive analysis corneal nerves, epithelium, dendritic cells (DCs), and clinical assessments. This cross-sectional study included 250 healthy smokers 272 non-smokers. Patients' status duration were recorded. In vivo confocal microscopy was performed to assess 7 quantitative nerves parameters, 3 neuroma DCs epithelial parameters. Ocular evaluations tear break-up time (TBUT), staining, sensitivity, Schirmer test. Surface Disease Index questionnaire used for symptom assessment. Compared non-smokers, exhibited significantly lower nerve fiber density (CNFD), branch density, length, total area (CNFA), fractal dimension (CFracDim; all p<0.001). Smokers also presented with a swollen (p<0.001). Longer associated CNFD (β=-0.04, P=0.010), CNFA (β=-0.00002, P=0.033), CFracDim (β=-0.0008, P=0.016). Additionally, larger (p=0.040), size (p<0.001) perimeter (p<0.001), as well higher count (p=0.003), elongation which suggested maturity observed in group. demonstrated staining scores reduced TBUT (p=0.001). Corneal circularity borderline subjects (p=0.059). Smoking is significant alterations morphology quantity, increased immunological cells, compromised integrity.

Language: Английский

Citations

0