Molecular characteristics, immune evasion, and impact of SARS-CoV-2 variants

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: June 28, 2022

Abstract The persistent COVID-19 pandemic since 2020 has brought an enormous public health burden to the global society and is accompanied by various evolution of virus genome. consistently emerging SARS-CoV-2 variants harboring critical mutations impact molecular characteristics viral proteins display heterogeneous behaviors in immune evasion, transmissibility, clinical manifestation during infection, which differ each strain endow them with distinguished features populational spread. Several variants, identified as Variants Concern (VOC) World Health Organization, challenged efforts on control due rapid worldwide spread enhanced evasion from current antibodies vaccines. Moreover, recent Omicron variant even exacerbated anxiety continuous pandemic. Its significant medical treatment disease highlights necessity combinatory investigation mutational pattern influence dynamics against immunity, would greatly facilitate drug vaccine development benefit policymaking. Hence this review, we summarized characteristics, impacts focused parallel comparison different profile, transmissibility tropism alteration, effectiveness, manifestations, order provide a comprehensive landscape for research.

Language: Английский

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Needleless electrospun phytochemicals encapsulated nanofibre based 3-ply biodegradable mask for combating COVID-19 pandemic

Chemical Engineering Journal, Journal Year: 2021, Volume and Issue: 416, P. 129152 - 129152

Published: Feb. 26, 2021

Language: Английский

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Ivermectin for the Treatment of Coronavirus Disease 2019: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Clinical Infectious Diseases, Journal Year: 2021, Volume and Issue: 74(6), P. 1022 - 1029

Published: June 25, 2021

We systematically assessed benefits and harms of the use ivermectin (IVM) in patients with coronavirus disease 2019 (COVID-19).

Language: Английский

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Recommendations for the management of COVID-19 in patients with haematological malignancies or haematopoietic cell transplantation, from the 2021 European Conference on Infections in Leukaemia (ECIL 9)

Leukemia, Journal Year: 2022, Volume and Issue: 36(6), P. 1467 - 1480

Published: April 29, 2022

Language: Английский

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Pro-Inflammatory and Anti-Inflammatory Interleukins in Infectious Diseases: A Comprehensive Review

Tropical Medicine and Infectious Disease, Journal Year: 2024, Volume and Issue: 9(1), P. 13 - 13

Published: Jan. 4, 2024

Interleukins (ILs) are signaling molecules that crucial in regulating immune responses during infectious diseases. Pro-inflammatory ILs contribute to the activation and recruitment of cells, whereas anti-inflammatory help suppress excessive inflammation promote tissue repair. Here, we provide a comprehensive overview role pro-inflammatory diseases, with focus on mechanisms underlying their effects, diagnostic therapeutic potential, emerging trends IL-based therapies.

Language: Английский

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