The incidence, characteristics and outcomes of pregnant women hospitalized with symptomatic and asymptomatic SARS-CoV-2 infection in the UK from March to September 2020: A national cohort study using the UK Obstetric Surveillance System (UKOSS) DOI Creative Commons
Nicola Vousden, Kathryn Bunch, Edward P. Morris

et al.

PLoS ONE, Journal Year: 2021, Volume and Issue: 16(5), P. e0251123 - e0251123

Published: May 5, 2021

Background There is a lack of population level data on risk factors, incidence and impact SARS-CoV-2 infection in pregnant women their babies. The primary aim this study was to describe the incidence, characteristics outcomes hospitalized with symptomatic asymptomatic UK compared without SARS-CoV-2. Methods findings We conducted national, prospective cohort all confirmed from 01/03/2020 31/08/2020 using Obstetric Surveillance System. Incidence rates were estimated national maternity data. Overall, 1148 had pregnancy, 63% which symptomatic. hospitalization 2.0 per 1000 maternities (95% CI 1.9–2.2) for 1.2 1.1–1.4). Compared SARS-CoV-2, more likely be overweight or obese (adjusted OR 1.86, 1.39–2.48) aOR 2.07 (1.53–2.29)), Black, Asian Other minority ethnic group (aOR 6.24, (3.93–9.90), 4.36, (3.19–5.95) 12.95, (4.93–34.01)), have relevant medical comorbidity 1.83 (1.32–2.54)). Hospitalized admitted intensive care 57.67, (7.80–426.70)) but absolute poor low. Cesarean births neonatal unit admission increased regardless symptom status (symptomatic 2.60, (1.97–3.42) 3.08, (1.99–4.77); 2.02, (1.52–2.70) 1.84, (1.12–3.03)). risks stillbirth death not significantly increased, status. Conclusions identified factors that increase pregnancy. Clinicians can reassured majority do experience severe complications

Language: Английский

Heart Disease and Stroke Statistics—2022 Update: A Report From the American Heart Association DOI Creative Commons

Connie W. Tsao,

Aaron W. Aday, Zaid Almarzooq

et al.

Circulation, Journal Year: 2022, Volume and Issue: 145(8)

Published: Jan. 26, 2022

The American Heart Association, in conjunction with the National Institutes of Health, annually reports most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, diet, weight) factors (cholesterol, blood pressure, glucose control) that contribute health. Statistical Update presents latest data on a range major clinical circulatory disease conditions (including congenital rhythm disorders, subclinical atherosclerosis, coronary failure, valvular venous peripheral artery disease) associated outcomes quality care, procedures, economic costs).

Language: Английский

Citations

4330

Heart Disease and Stroke Statistics—2023 Update: A Report From the American Heart Association DOI Creative Commons

Connie W. Tsao,

Aaron W. Aday, Zaid Almarzooq

et al.

Circulation, Journal Year: 2023, Volume and Issue: 147(8)

Published: Jan. 25, 2023

Background: The American Heart Association, in conjunction with the National Institutes of Health, annually reports most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, diet, weight) factors (cholesterol, blood pressure, glucose control) that contribute health. Statistical Update presents latest data on a range major clinical circulatory disease conditions (including congenital rhythm disorders, subclinical atherosclerosis, coronary failure, valvular venous peripheral artery disease) associated outcomes quality care, procedures, economic costs). Methods: through its Epidemiology Prevention Statistics Committee, continuously monitors evaluates sources stroke United States provide current information available annual review published literature year before writing. 2023 is product full year’s worth effort 2022 by dedicated volunteer clinicians scientists, committed government professionals, Association staff members. strives further understand help heal problems inflicted structural racism, public crisis can significantly damage mental perpetuate disparities access education, income, housing, several other vital healthy lives. This edition includes additional COVID-19 (coronavirus 2019) publications, as well monitoring benefits population, an enhanced focus equity across key domains. Results: Each chapters focuses different topic statistics. Conclusions: represents critical resource for lay public, policymakers, media clinicians, care administrators, researchers, advocates, others seeking best these conditions.

Language: Английский

Citations

4309

Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and meta-analysis DOI Creative Commons
John Allotey, Silvia Fernández-García, Mercedes Bonet

et al.

BMJ, Journal Year: 2020, Volume and Issue: unknown, P. m3320 - m3320

Published: Sept. 1, 2020

Abstract Objective To determine the clinical manifestations, risk factors, and maternal perinatal outcomes in pregnant recently women with suspected or confirmed coronavirus disease 2019 (covid-19). Design Living systematic review meta-analysis. Data sources Medline, Embase, Cochrane database, WHO COVID-19 China National Knowledge Infrastructure (CNKI), Wanfang databases from 1 December to 27 April 2021, along preprint servers, social media, reference lists. Study selection Cohort studies reporting rates, manifestations (symptoms, laboratory radiological findings), covid-19. extraction At least two researchers independently extracted data assessed study quality. Random effects meta-analysis was performed, estimates pooled as odds ratios difference proportions 95% confidence intervals. All analyses are updated regularly. Results 435 were included. Overall, 9% (95% interval 7% 10%; 149 studies, 926 232 women) of attending admitted hospital for any reason diagnosed having The most common covid-19 pregnancy fever cough (both 36%). Compared non-pregnant reproductive age, less likely report symptoms fever, dyspnoea, cough, myalgia. admission an intensive care unit (odds ratio 2.61, 1.84 3.71; I 2 =85.6%), invasive ventilation (2.41, 2.13 2.71; =0%) higher than age. 970 (0.2%, 123 179 981 died cause. In covid-19, non-white ethnicity, increased high body mass index, pre-existing comorbidity including chronic hypertension diabetes, specific complications such gestational diabetes pre-eclampsia, associated serious (severe unit, ventilation, death). without those had death 6.09, 1.82 20.38; =76.6%), (5.41, 3.59 8.14; =57.0%), caesarean section (1.17, 1.01 1.36; =80.3%), preterm birth (1.57, 1.36 1.81; =49.3%). stillbirth (1.81, 1.38 2.37, =0%), neonatal (2.18, 1.46 3.26, =85.4%) babies born versus Conclusion Pregnant hospitals manifest myalgia, but more be needing Pre-existing comorbidities, hypertension, index factors severe pregnancy. deliver have being unit. Their Systematic registration PROSPERO CRD42020178076. Readers’ note This article is a living that will reflect emerging evidence. Updates may occur up years date original publication. version update published on September 2020 ( BMJ 2020;370:m3320), previous updates can found supplements https://www.bmj.com/content/370/bmj.m3320/related#datasupp ). When citing this paper please consider adding number access clarity.

Language: Английский

Citations

2140

Update: Characteristics of Symptomatic Women of Reproductive Age with Laboratory-Confirmed SARS-CoV-2 Infection by Pregnancy Status — United States, January 22–October 3, 2020 DOI Open Access
Laura D. Zambrano, Sascha Ellington, Penelope Strid

et al.

MMWR Morbidity and Mortality Weekly Report, Journal Year: 2020, Volume and Issue: 69(44), P. 1641 - 1647

Published: Nov. 2, 2020

Studies suggest that pregnant women might be at increased risk for severe illness associated with coronavirus disease 2019 (COVID-19) (1,2). This report provides updated information about symptomatic of reproductive age (15-44 years) laboratory-confirmed infection SARS-CoV-2, the virus causes COVID-19. During January 22-October 3, CDC received reports through national COVID-19 case surveillance or National Notifiable Diseases Surveillance System (NNDSS) 1,300,938 aged 15-44 years laboratory results indicative acute SARS-CoV-2. Data on pregnancy status were available 461,825 (35.5%) infection, 409,462 (88.7%) whom symptomatic. Among women, 23,434 (5.7%) reported to pregnant. After adjusting age, race/ethnicity, and underlying medical conditions, significantly more likely than nonpregnant admitted an intensive care unit (ICU) (10.5 versus 3.9 per 1,000 cases; adjusted ratio [aRR] = 3.0; 95% confidence interval [CI] 2.6-3.4), receive invasive ventilation (2.9 1.1 aRR 2.9; CI 2.2-3.8), extracorporeal membrane oxygenation (ECMO) (0.7 0.3 2.4; 1.5-4.0), die (1.5 1.2 1.7; 1.2-2.4). Stratifying these analyses by race/ethnicity highlighted disparities in subgroup. Although absolute risks outcomes low, COVID-19-associated illness. To reduce death from COVID-19, should counseled importance seeking prompt if they have symptoms measures prevent SARS-CoV-2 strongly emphasized their families during all encounters, including prenatal visits. Understanding among is important prevention counseling clinical treatment.

Language: Английский

Citations

1177

2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association DOI Creative Commons
Seth S. Martin, Aaron W. Aday, Zaid Almarzooq

et al.

Circulation, Journal Year: 2024, Volume and Issue: 149(8)

Published: Jan. 24, 2024

BACKGROUND: The American Heart Association (AHA), in conjunction with the National Institutes of Health, annually reports most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, nutrition, sleep, obesity) factors (cholesterol, blood pressure, glucose control, metabolic syndrome) that contribute health. AHA Disease Stroke Statistical Update presents latest data on a range major clinical circulatory disease conditions (including brain health, complications pregnancy, kidney congenital rhythm disorders, sudden cardiac arrest, subclinical atherosclerosis, coronary cardiomyopathy, failure, valvular venous thromboembolism, peripheral artery disease) associated outcomes quality care, procedures, economic costs). METHODS: AHA, through its Epidemiology Prevention Statistics Committee, continuously monitors evaluates sources stroke United States globally provide current information available annual review published literature year before writing. 2024 is product full year’s worth effort 2023 by dedicated volunteer clinicians scientists, committed government professionals, staff members. strives further understand help heal problems inflicted structural racism, public crisis can significantly damage mental perpetuate disparities access education, income, housing, several other vital healthy lives. This edition includes additional global data, as well monitoring benefits population, an enhanced focus equity across key domains. RESULTS: Each chapters focuses different topic statistics. CONCLUSIONS: represents critical resource for lay public, policymakers, media clinicians, care administrators, researchers, advocates, others seeking best these conditions.

Language: Английский

Citations

979

Comparing COVID-19 vaccines for their characteristics, efficacy and effectiveness against SARS-CoV-2 and variants of concern: a narrative review DOI Creative Commons
Thibault Fiolet, Yousra Kherabi,

Conor-James MacDonald

et al.

Clinical Microbiology and Infection, Journal Year: 2021, Volume and Issue: 28(2), P. 202 - 221

Published: Oct. 27, 2021

Language: Английский

Citations

842

Preliminary Findings of mRNA Covid-19 Vaccine Safety in Pregnant Persons DOI Open Access
Tom T. Shimabukuro, Shin Y. Kim, Tanya R. Myers

et al.

New England Journal of Medicine, Journal Year: 2021, Volume and Issue: 384(24), P. 2273 - 2282

Published: April 21, 2021

Many pregnant persons in the United States are receiving messenger RNA (mRNA) coronavirus disease 2019 (Covid-19) vaccines, but data limited on their safety pregnancy.From December 14, 2020, to February 28, 2021, we used from "v-safe after vaccination health checker" surveillance system, v-safe pregnancy registry, and Vaccine Adverse Event Reporting System (VAERS) characterize initial of mRNA Covid-19 vaccines persons.A total 35,691 participants 16 54 years age identified as pregnant. Injection-site pain was reported more frequently among than nonpregnant women, whereas headache, myalgia, chills, fever were less frequently. Among 3958 enrolled 827 had a completed pregnancy, which 115 (13.9%) resulted loss 712 (86.1%) live birth (mostly with third trimester). neonatal outcomes included preterm (in 9.4%) small size for gestational 3.2%); no deaths reported. Although not directly comparable, calculated proportions adverse vaccinated against who similar incidences studies involving women that conducted before pandemic. 221 pregnancy-related events VAERS, most event spontaneous abortion (46 cases).Preliminary findings did show obvious signals received vaccines. However, longitudinal follow-up, including follow-up large numbers earlier is necessary inform maternal, infant outcomes.

Language: Английский

Citations

835

The impact of COVID-19 on pregnancy outcomes: a systematic review and meta-analysis DOI Creative Commons
Shu Qin Wei, Marianne Bilodeau‐Bertrand, Shiliang Liu

et al.

Canadian Medical Association Journal, Journal Year: 2021, Volume and Issue: 193(16), P. E540 - E548

Published: March 19, 2021

The impact of coronavirus disease 2019 (COVID-19) on maternal and newborn health is unclear. We aimed to evaluate the association between severe acute respiratory syndrome 2 (SARS-CoV-2) infection during pregnancy adverse outcomes.We conducted a systematic review meta-analysis observational studies with comparison data SARS-CoV-2 severity COVID-19 pregnancy. searched for eligible in MEDLINE, Embase, ClinicalTrials.gov, medRxiv Cochrane databases up Jan. 29, 2021, using Medical Subject Headings terms keywords "severe OR COVID-19" AND "pregnancy." evaluated methodologic quality all included Newcastle-Ottawa Scale. Our primary outcomes were preeclampsia preterm birth. Secondary stillbirth, gestational diabetes other outcomes. calculated summary odds ratios (ORs) or weighted mean differences 95% confidence intervals (CI) random-effects meta-analysis.We 42 involving 438 548 people who pregnant. Compared no pregnancy, was associated (OR 1.33, CI 1.03 1.73), birth 1.82, 1.38 2.39) stillbirth 2.11, 1.14 3.90). mild COVID-19, strongly 4.16, 1.55 11.15), 4.29, 2.41 7.63), 1.99, 1.09 3.64) low weight 1.89, 3.12).COVID-19 may be increased risks preeclampsia,

Language: Английский

Citations

800

The impact of the COVID-19 pandemic on maternal and perinatal health: a scoping review DOI Creative Commons
Bethany Kotlar,

Emily Gerson,

Sophia Petrillo

et al.

Reproductive Health, Journal Year: 2021, Volume and Issue: 18(1)

Published: Jan. 18, 2021

Abstract Introduction The Covid-19 pandemic affects maternal health both directly and indirectly, direct indirect effects are intertwined. To provide a comprehensive overview on this broad topic in rapid format behooving an emergent we conducted scoping review. Methods A review was to compile evidence impacts of the most significant outcomes thus far. Working papers news articles were considered appropriate along with peer-reviewed publications order capture rapidly evolving updates. Literature English published from January 1st September 11 2020 included if it pertained or COVID-19 physical, mental, economic, social wellbeing pregnant people. Narrative descriptions written about subject areas for which authors found evidence. Results search yielded 396 publications, 95 included. Pregnant individuals be at heightened risk more severe symptoms than people who not pregnant. Intrauterine, vertical, breastmilk transmission unlikely. Labor, delivery, breastfeeding guidelines positive patients varied. Severe increases mental issues, such as clinically relevant anxiety depression, reported. Domestic violence appeared spike. Prenatal care visits decreased, healthcare infrastructure strained, potentially harmful policies implemented little Women likely lose their income due men, working mothers struggled increased childcare demands. Conclusion women higher infection pregnant, however symptomatic may experience adverse compared non-pregnant seem face disproportionate socio-economic consequences. High low- middle-income countries alike faced struggles. Further resources should directed towards quality epidemiological studies. Plain summary reproductive perinatal through itself but also indirectly consequence changes care, policy, economic circumstances. consequences have Intrauterine transmission, passage virus mother baby during delivery labor, vary, variability could create uncertainty unnecessary harm. high low/middle countries. impact is marked. frequency problems, epidemic reported many This reflects increase studies demonstrating true change lacking. vulnerable losing We make several recommendations: studies, services diminished, focus needed.

Language: Английский

Citations

602

Disease Severity and Perinatal Outcomes of Pregnant Patients With Coronavirus Disease 2019 (COVID-19) DOI Open Access
Torri D. Metz,

Rebecca G. Clifton,

Brenna L. Hughes

et al.

Obstetrics and Gynecology, Journal Year: 2021, Volume and Issue: 137(4), P. 571 - 580

Published: Feb. 8, 2021

OBJECTIVE: To describe coronavirus disease 2019 (COVID-19) severity in pregnant patients and evaluate the association between perinatal outcomes. METHODS: We conducted an observational cohort study of all with a singleton gestation positive test result for severe acute respiratory syndrome 2 (SARS-CoV-2) who delivered at 1 33 U.S. hospitals 14 states from March to July 31, 2020. Disease was classified by National Institutes Health criteria. Maternal, fetal, neonatal outcomes were abstracted centrally trained certified research staff. evaluated trends maternal characteristics across COVID-19 classes associations multivariable modeling. RESULTS: A total 1,219 included: 47% asymptomatic, 27% mild, 14% moderate, 8% severe, 4% critical. Overall, 53% Hispanic; there no trend race–ethnicity distribution severity. Those more illness had older mean age, higher median body mass index, pre-existing medical comorbidities. Four deaths (0.3%) attributed COVID-19. Frequency death or SARS-CoV-2 did not differ Adverse frequent among illness, including 6% (95% CI 2–11%) incidence venous thromboembolism those severe–critical compared 0.2% mild–moderate 0% asymptomatic ( P <.001 severity). In adjusted analyses, associated increased risk cesarean birth (59.6% vs 34.0%, relative [aRR] 1.57, 95% 1.30–1.90), hypertensive disorders pregnancy (40.4% 18.8%, aRR 1.61, 1.18–2.20), preterm (41.8% 11.9%, 3.53, 2.42–5.14) patients. Mild–moderate adverse CONCLUSION: Compared infection without symptoms, COVID-19, but complications.

Language: Английский

Citations

404