Gut,
Journal Year:
2025,
Volume and Issue:
unknown, P. gutjnl - 333171
Published: April 1, 2025
Autoimmune
hepatitis
(AIH)
is
a
chronic
inflammatory
liver
disease
which,
if
untreated,
often
leads
to
cirrhosis,
failure
and
death.
The
last
British
Society
of
Gastroenterology
(BSG)
guideline
for
the
management
AIH
was
published
in
2011.
Since
then,
our
understanding
has
advanced
many
areas.
This
update
previous
commissioned
by
BSG
developed
multidisciplinary
group.
aim
this
review
summarise
current
evidence,
order
inform
guide
diagnosis
patients
with
its
variant
syndromes.
main
focus
on
adults,
but
guidelines
should
also
be
relevant
older
children
adolescents.
Pneumologie,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 19, 2025
Sarcoidosis
is
a
granulomatous
multi-system
disease
of
unknown
aetiology
[1].
10–30
%
the
chronic
subpopulations
require
prolonged
treatment
[1],
most
commonly
in
form
systemic
glucocorticoids
(GC),
which
are
considered
first
line
for
symptomatic
sarcoidosis
patients
[2]
[3]
[4].
Symptoms
often
unspecific
and
include
fatigue,
arthralgia,
muscle
pain,
general
weakness,
fever
anorexia.
Of
all
symptoms,
fatigue
poses
prevalent
clinical
feature
seen
nearly
70
[1]
[5].
However,
may
also
be
caused
by
suppression
hypothalamic-pituitary-adrenal
(HPA)
axis
as
an
inevitable
effect
exogenous
glucocorticoid
therapy
[6].
This
can
manifest
glucocorticoid-induced
adrenal
insufficiency
(GI-AI),
among
common
causes
cortisol
deficiency
[7].
Clinical
symptoms
GI-AI
[8]
overlap
with
aforementioned
sarcoidosis.
To
our
knowledge,
no
data
available
on
prevalence
patients.
Recently,
current
or
recent
history
GC
use
presenting
signs
suggestive
classified
being
at
high
risk
should,
if
they
currently
receive
dose
5
mg
prednisolone
equivalent,
tested
measuring
early
morning
serum
24
hours
after
last
GCs
Therefore,
between
March
2022
May
2023
we
prospectively
evaluated
62
consecutive
histologically
proven
receiving
less
equivalent
development
insufficiency.
Study
inclusion
required
informed
written
consent.
The
study
was
approved
ethics
committee
University
Bonn.
Musculoskeletal Care,
Journal Year:
2025,
Volume and Issue:
23(2)
Published: March 27, 2025
ABSTRACT
Introduction
Abrupt
discontinuation
of
low
dose
glucocorticoids
(GCs)
in
systemic
lupus
erythematosus
(SLE)
patients
with
clinical
quiescent
disease
increased
the
risk
flares.
This
study
aimed
to
evaluate
effect
a
gradual
GC
withdrawal
scheme
on
flare
rate
among
SLE
sustained
remission.
Methods
who
received
prednisolone
5
mg/day
for
at
least
4
weeks
and
had
Disease
Activity
Index‐2000
(cSLEDAI‐2K)
=
0
minimum
6
months
were
recruited.
The
participants
randomly
assigned
1:1
ratio
either
16‐week
(withdrawal
group)
or
continuation
24
(maintenance
planned
enrolment
36.
primary
outcome
was
proportion
experiencing
flare,
defined
change
cSLEDAI‐2K
≥
4,
SLE‐Disease
Score
1.72
any
treatment
escalation
over
weeks.
Results
Twenty
maintenance
group
(10
patients),
patients).
higher
compared
(3
vs.
1
patient;
HR
3.57;
95%
CI
0.37
34.51,
p
0.24).
All
experienced
serologically
active
clinically
screening.
Adverse
events
(AEs)
occurred
more
(7
Two
trial
terminated
early
due
occurrence
flares
AEs.
Conclusion
Gradual
tapering
showed
non‐significant
relapse
AEs
Clinical
number
registered
ClinicalTrials.gov,
NCT06234852.
Gut,
Journal Year:
2025,
Volume and Issue:
unknown, P. gutjnl - 333171
Published: April 1, 2025
Autoimmune
hepatitis
(AIH)
is
a
chronic
inflammatory
liver
disease
which,
if
untreated,
often
leads
to
cirrhosis,
failure
and
death.
The
last
British
Society
of
Gastroenterology
(BSG)
guideline
for
the
management
AIH
was
published
in
2011.
Since
then,
our
understanding
has
advanced
many
areas.
This
update
previous
commissioned
by
BSG
developed
multidisciplinary
group.
aim
this
review
summarise
current
evidence,
order
inform
guide
diagnosis
patients
with
its
variant
syndromes.
main
focus
on
adults,
but
guidelines
should
also
be
relevant
older
children
adolescents.
