Russian Journal of Cardiology,
Journal Year:
2024,
Volume and Issue:
29(11S), P. 5945 - 5945
Published: Sept. 24, 2024
Coronary
artery
disease
(CAD)
and
depression
are
characterized
by
high
bilateral
comorbidity,
but
its
pathogenesis
is
practically
not
studied.
In
the
last
decade,
neurogenic
mechanisms
of
inflammatory
response
brain-derived
neurotrophic
factor
(BDNF),
which
can
explain
relationship
between
CAD,
have
been
The
review
summarizes
available
information
on
BDNF
role
in
CAD
depression,
as
well
their
comorbid
course
for
period
2019-2024.
Based
literature
review,
we
identified
components
systems
that
most
promising
studying
these
multifactorial
diseases
(genetics,
inflammation,
neuroinflammation,
endothelial
dysfunction
platelet
hyperactivation,
hypothalamic-pituitary-adrenal
system,
low-density
lipoproteins
triglycerides).
emphasizes
important
development
need
further
research
this
area.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Sept. 27, 2024
Introduction
The
complex
and
unresolved
pathogenesis
of
schizophrenia
has
posed
significant
challenges
to
its
diagnosis
treatment.
While
recent
research
established
a
clear
association
between
immune
function
schizophrenia,
the
causal
relationship
two
remains
elusive.
Methods
We
employed
bidirectional
two-sample
Mendelian
randomization
approach
investigate
731
cell
traits
by
utilizing
public
GWAS
data.
further
validated
six
types
white
measures.
Results
found
overall
effects
on
were
significantly
higher
than
reverse
ones
(0.011
±
0.049
vs
0.001
0.016,
p
<
0.001),
implying
that
disease
may
lead
an
increase
in
cells
itself.
also
identified
four
risk
schizophrenia:
CD11c+
monocyte
%monocyte
(odds
ratio
(OR):
1.06,
95%
confidence
interval
(CI):
1.03~1.09,
FDR
=
0.027),
CD62L-
(OR:1.06,
CI:
CD25
IgD+
CD38-
naive
B
(OR:1.03,
CI:1.01~1.06,
0.042),
CD86
(OR
1.04,
0.042).
However,
we
did
not
detect
any
traits.
Using
blood
data,
increases
lymphocyte
counts
95%CI:
1.01-1.04,
0.007),
total
(OR:1.02,
0.021)
1.00-1.03,
0.034).
nominally
associated
with
(OR:1.08,95%CI:1.01-1.16,
P=0.019).
Discussion
Our
study
system
is
complex,
enhancing
our
understanding
role
regulation
development
this
disorder.
These
findings
offer
new
insights
for
exploring
diagnostic
therapeutic
options
schizophrenia.
BMC Psychiatry,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: July 8, 2024
Abstract
Background
Existing
evidence
suggests
that
alterations
in
the
gut
microbiome
are
closely
associated
with
major
depressive
disorder
(MDD).
We
aimed
to
reveal
causal
relationships
between
MDD
and
various
microbial
taxa
gut.
Methods
used
two-sample
Mendelian
randomization
(TSMR)
explore
bidirectional
effects
microbiota
MDD.
The
genome-wide
association
studies
summary
results
of
were
obtained
from
two
large
consortia,
MibioGen
consortium
Dutch
Microbiome
Project,
which
we
analyzed
separately.
Results
Our
TSMR
analysis
identified
10
bacterial
protective
against
MDD,
including
phylum
Actinobacteria
,
order
Clostridiales
family
Bifidobacteriaceae
(OR:
0.96
∼
0.98).
Ten
an
increased
risk
phyla
Firmicutes
Proteobacteria
class
genus
Alistipes
1.01
1.09).
On
other
hand,
may
decrease
abundance
12
taxa,
families
Defluviitaleaceae
0.63
0.88).
increase
8
Bacteroidetes
genera
Parabacteroides
Bacteroides
1.12
1.43).
Conclusions
study
supports
there
mutual
certain
development
suggesting
be
targeted
treatment
Diagnostics,
Journal Year:
2025,
Volume and Issue:
15(3), P. 239 - 239
Published: Jan. 21, 2025
Mental
disorders
(MDs)
are
among
the
major
causes
of
morbidity
and
mortality
worldwide.
Individuals
with
severe
MDs
have
a
shorter
life
expectancy,
primarily
due
to
cardiovascular
diseases.
Echocardiography
facilitates
evaluation
alterations
in
cardiac
morphology
function,
resulting
from
various
pathologies.
The
aim
this
review
was
explore
current
evidence
base
behind
myocardial
deformation
observed
echocardiography
patients
MDs.
We
focused
on
data
regarding
speckle
tracking
echocardiography.
PubMed,
using
medical
subject
headings,
searched
identify
studies
topic.
collected
demonstrated
changes
function
schizophrenia,
bipolar
disorder,
depression,
anxiety
stressor-related
post-traumatic
stress
eating
disorders,
sleep–wake
substance-related
addictive
neurocognitive
borderline
personality
disorder.
recurrent
findings
included
impaired
Left
Ventricular
Ejection
Fraction
Hypertrophy.
Global
Longitudinal
Strain
significantly
altered
anorexia
nervosa,
disorders.
All
reported
support
consideration
cardiology
consultations
multidisciplinary
approach
care
suspected
dysfunction.
Further
investigation
is
warranted
determine
significance
prognostic
value
strain
measurements
individuals
MDs,
focusing
early
detection,
especially
asymptomatic
cases.
Issues in Mental Health Nursing,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 9
Published: March 21, 2025
Psychotropic
drugs
dominate
the
mental
healthcare
landscape.
This
is
despite
contention
over
their
proposed
mechanism
of
action,
concerns
for
adverse
effects,
and
questionable
effectiveness,
especially
long
term.
Mental
health
nurses
are
routinely
involved
in
administering
psychotropic
drugs,
observing
managing
providing
information
support
to
people
prescribed
these
agents.
critique
explores
current
understanding
action
evidence
effect
burden
implications
term
use.
The
role
deprescribing
supporting
discontinue
treatment
considered.
Drugs - Real World Outcomes,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 16, 2025
The
relationship
between
antidepressants,
depression,
and
the
incidence
of
postpartum
hemorrhage
(PPH)
has
been
reported
in
observational
studies,
but
causal
link
these
factors
remains
unknown.
Clarifying
this
is
important
for
treating
depression
during
pregnancy
managing
PPH.
We
aimed
to
assess
PPH
using
a
two-sample
Mendelian
randomization
method.
Single
nucleotide
polymorphisms
were
identified
from
publicly
available
genetics
summary
databases
(FinnGen
database,
access
date:
28
December,
2023,
version
R9,
phenocode:
ANTIDEPRESSANTS,
195,321
participants;
genome-wide
association
studies
[GWAS]
catalog,
3
April,
2024,
GWAS
ID:
ebi-a-GCST90016607;
Integrative
Epidemiological
Unit
ieu-a-1187)
as
alternative
exposure
antidepressants
depression.
Subsequently,
inverse
variance
weighting,
randomization-Egger
regression,
weighted
median,
simple
method,
method
employed
analyses,
results
validated
pleiotropy,
heterogeneity,
sensitivity.
analyses
three
sets
genetic
tools,
comprising
two
9
32
single
that
are
strongly
associated
with
another
set
26
antidepressants.
weighting
indicated
(odds
ratio
=
1.36,
95%
confidence
interval
1.10-1.69,
p
0.005).
Conversely,
none
five
methods
analysis
an
effect
on
This
antidepressant
use
However,
evidence
does
not
support
