Harnessing the Power of Nanocarriers to Exploit the Tumor Microenvironment for Enhanced Cancer Therapy DOI Creative Commons
Bandar E. Al‐Dhubiab, Rashed M. Almuqbil, Anroop B. Nair

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(5), P. 746 - 746

Published: May 19, 2025

The tumor microenvironment (TME) has a major role in malignancy and its complex nature can mediate survival, metastasis, immune evasion, drug resistance. Thus, reprogramming or regulating the immunosuppressive TME significant contribution to make cancer therapy. Targeting with nanocarriers (NCs) been widely used directly deliver anticancer drugs control TME, which revealed auspicious outcomes. be reprogrammed by using range of NCs regulate factors activate immunostimulatory cells. Moreover, ameliorated via redox environment, oxygen content, pH value site. have capacity provide site-specific delivery therapeutic agents, controlled release, enhanced solubility stability, decreased toxicities, pharmacokinetics as well biodistribution. Numerous demonstrated their potential inducing distinct mechanisms delivering various preclinical studies, including metal NCs, liposomal solid lipid micelles, nanoemulsions, polymer-based dendrimers, nanoclays, nanocrystals, many more. Some them already received US Food Drug Administration approval, some entered different clinical phases. However, there are several challenges NC-mediated targeting, scale-up NC-based therapy, rapid clearance mononuclear phagocyte system, heterogeneity. In order harness full treatment, that need carefully studied, optimization loading into NC-associated immunogenicity, biocompatibility for successful translation therapies practice. this review, applications remodel therapy extensively discussed. findings from numerous studies these also highlighted.

Language: Английский

Liposomes as Immunotherapeutic Carriers: A Game-Changer in Cancer Therapy DOI

Sepehr Hoseinzadeh Moghaddam,

Abulfazl Vatankhah,

Fatemeh Oroojalian

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106847 - 106847

Published: March 1, 2025

Language: Английский

Citations

3
Nanomedicine: a cost-effective and powerful platform for managing neurodegenerative diseases DOI

Majid Hassanzadeh-khanmiri,

Amirreza Moshari,

Reza Kheradmand

et al.

Metabolic Brain Disease, Journal Year: 2025, Volume and Issue: 40(3)

Published: March 11, 2025

Language: Английский

Citations

1
Clinical Applications of Targeted Nanomaterials DOI Creative Commons

Ankesh Kumar,

SK Shahvej,

Pankaj Yadav

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 379 - 379

Published: March 17, 2025

Targeted nanomaterials are at the forefront of advancements in nanomedicine due to their unique and versatile properties. These include nanoscale size, shape, surface chemistry, mechanical flexibility, fluorescence, optical behavior, magnetic electronic characteristics, as well biocompatibility biodegradability. attributes enable application across diverse fields, including drug delivery. This review explores fundamental characteristics emphasizes importance clinical applications. It further delves into methodologies for nanoparticle programming alongside discussions on trials case studies. We discussed some promising nanomaterials, such polymeric nanoparticles, carbon-based metallic role biomedical underscores significant translating applications highlights potential these innovative approaches revolutionizing medical field.

Language: Английский

Citations

1
From Bench to Bedside: Advancing Liposomal Doxorubicin for Targeted Cancer Therapy DOI Creative Commons
Mohammad Zaki Ahmad, Gulam Mustafa, Basel A. Abdel‐Wahab

et al.

Results in Surfaces and Interfaces, Journal Year: 2025, Volume and Issue: unknown, P. 100473 - 100473

Published: March 1, 2025

Language: Английский

Citations

0
Fabrication of Bioconjugates Clacked Chitosan‐Coated SN‐38 Liposomal Nanoparticles: Improved Precise Chemotherapy Efficacy in Lung Cancer Cells and Its Apoptosis DOI Open Access
Xiaojun Zhang, Wei Sun,

Changting Liu

et al.

Biotechnology and Applied Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

ABSTRACT Employing an active targeting method with monoclonal antibodies for chemotherapeutics‐loaded nanocarriers represents a promising option to enhance the specific drug delivery and alleviate detrimental effects of chemotherapeutic agents. Targeted human epidermal growth factor receptor‐2 (HER2), which is overexpressed in HER2+ lung cancerous cells, can be accomplished by conjugating nanoparticles antibody (anti‐HER2). We developed trastuzumab (TZ)‐conjugated chitosan iodoacetamide (CsIA)‐coated liposomal carrying SN‐38 (TZ‐SN‐CsIA LNPs) as lung‐targeted delivery. CsIA was used develop trastuzumab‐clacked (TZ LNPs). The structure, physicochemical characteristics, encapsulation, release, anticancer properties LNPs were established. TZ spherical, measuring around 77 nm diameter, exhibited positive zeta potential; upon incorporation, diameter enlarged. A sustained, 24‐h release from accomplished. demonstrated substantial cellular accumulation markedly enhanced efficacy against Calu‐3 adenocarcinoma cancer cells compared solution unconjugated LNPs. Consequently, TZ‐SN‐CsIA may potential nanocarrier cancer.

Language: Английский

Citations

0
Cancer nanomedicine from a clinician-scientist perspective: Lessons and prospects DOI Creative Commons
Alberto Gabizón

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113731 - 113731

Published: April 1, 2025

Language: Английский

Citations

0
Nanotechnology-Enhanced siRNA Delivery: Revolutionizing Cancer Therapy DOI

Donya Esmaeilpour,

Matineh Ghomi, Ehsan Nazarzadeh Zare‬

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 12, 2025

RNA interference (RNAi) has emerged as a transformative approach for cancer therapy, enabling precise gene silencing through small interfering (siRNA). However, the clinical application of siRNA-based treatments faces challenges such rapid degradation, inefficient cellular uptake, and immune system clearance. Nanotechnology-enhanced siRNA delivery revolutionized therapy by addressing these limitations, improving stability, tumor-specific targeting, therapeutic efficacy. Recent advancements in nanocarrier engineering have introduced innovative strategies to enhance safety precision therapies, offering new opportunities personalized medicine. This review highlights three key innovations nanotechnology-enhanced delivery: artificial intelligence (AI)-driven design, multifunctional nanoparticles combined strategies, biomimetic nanocarriers enhanced biocompatibility. AI-driven utilize machine learning algorithms optimize nanoparticle properties, drug release profiles minimizing off-target effects. Multifunctional integrate with chemotherapy, immunotherapy, or photothermal synergistic treatment approaches that outcomes reduce resistance. Biomimetic nanocarriers, including exosome-mimicking systems cell-membrane-coated nanoparticles, improve circulation time, evasion, targeted tumor delivery. These collectively precision, efficiency, therapies. The scope novelty lie their ability overcome primary barriers while paving way clinically viable solutions. provides comprehensive analysis latest developments fabrication, preclinical studies, assessments. By integrating multifunctionality, biomimicry, holds immense potential future therapy.

Language: Английский

Citations

0
Role of tumor microenvironment in ovarian cancer metastasis and clinical advancements DOI Creative Commons
Yang Wang, Na Zhu, Jing Liu

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: May 14, 2025

Language: Английский

Citations

0
Modulation of Doxorubicin-Induced ROS Accumulation in Cardiomyocytes Using Ibuprofen-Conjugated Synthetic Lipids as Carriers DOI

Soumya Saroj,

Akshaya Kana Veedu,

Chandrasekhar Reddy U

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 23, 2025

Conjugation of an NSAID such as ibuprofen to the head group oxanorbornane-based lipids and use their aggregates carriers for doxorubicin (Dox) are discussed here. These conjugates were characterized by various spectroscopic techniques, including 2D-NMR, insights into assembly gathered through PXRD, AFM, SEM, DLS, qNano techniques. Free well formulations (lipid:cholesterol:Dox in a 3:1.5:2 molar ratio) showed high tendency form solid lipid particles, which was verified TEM analysis. The presence unit led increase interlipid spacing characteristic change packing. Active loading pH gradient allowed us achieve drug entrapment controlled release profile. formulation AT3.3, prepared this method, Dox ∼90%, with ∼18% end 24 h; only ∼66% entrapped released 5 days. Cytotoxicity studies NIH3T3 cells hemolytic assay results that these have good safety Results from flow cytometry experiments A549 revealed AT3.3 induces effects similar free Dox, cell cycle arrest predominantly at S phase G2/M phase. At same time, response blank comparable control. Confocal microscopy gets localized mainly nucleus, while carrier (AT3.3) causes significant localization on cytoplasmic side well. ROS induction due its cardiomyocytes also compared, protective effect when using formulation.

Language: Английский

Citations

0
Sustainable and Eco-Friendly Nanomaterials DOI
Anita Restu Puji Raharjeng, Evika Sandi Savitri, Ruqiah Ganda Putri Panjaitan

et al.

IGI Global eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 143 - 180

Published: April 25, 2025

This book chapter elucidates key concepts such as the molecular mechanisms of life, biomolecular synthesis, bioenergetics, and chemical interactions within biological systems. integrated approach is designed to support a science curriculum that meets contemporary needs, emphasizing exploration real-world phenomena through laboratory experiments, digital simulations, cutting-edge technological applications. also highlights importance global issues climate change, waste management, public health in context biology chemistry. With research-driven methodology problem-based learning approaches, it offers practical guidance for educators, students, researchers effectively apply various academic industrial contexts. Through educational innovation cross-disciplinary integration, Molecular Revolution aims inspire transformation teaching learning, building strong foundation future generations address challenges with knowledge empathy.

Language: Английский

Citations

0