Updates on the neurological manifestations of SARS-CoV-2 infection

Current Opinion in Infectious Diseases, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Purpose of review Since its emergence in 2020, the COVID-19 pandemic has created a global surge survivors experiencing neurologic effects from SARS-CoV-2 infection. This aims to provide an updated synthesis acute and chronic neurological manifestations COVID-19, outline current therapeutic strategies for these conditions. Recent findings Epidemiological studies have shown that patients with symptoms during infection tend poorer hospital functional outcomes. While risk adverse including cognitive dysfunction, headache, autonomic fatigue are thought be greatest following original strain alpha variant, they remain prevalent after subsequent less virulent strains as well. Some recent work also found link between structural brain changes. However, ongoing trials show promising results pharmacologic nonpharmacologic treatments targeting postacute sequelae COVID-19. Summary Lingering still pose considerable individual, healthcare system, socioeconomic repercussions. Both preventive multimodal treatment approaches necessary address Further research is required assess lasting impacts on nervous particularly potential contribution development neurodegenerative diseases.

Language: Английский

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Sociodemographic and psychosocial correlates of fatigue and chronic fatigue: A cross-sectional study from a South East London community survey

Journal of Psychosomatic Research, Journal Year: 2025, Volume and Issue: 193, P. 112146 - 112146

Published: May 9, 2025

Language: Английский

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Elevated adipokines and myokines are associated with fatigue in long COVID patients

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: May 19, 2025

Background Persistent fatigue is one of the most common and debilitating symptoms experienced by patients recovering from COVID-19, contributing significantly to burden “long COVID” or post-COVID-19syndrome. However, underlying pathophysiological mechanisms remain inadequately understood. Few studies have examined association between pulmonary cardiac function, systemic biomarkers, morphological changes in lungs diaphragm. Furthermore, potential influence vaccination on persistence has not been fully explored. This study aims identify post-COVID-19 fatigue. Methods prospective cohort assessed clinical, laboratory, pulmonary, parameters, as well diaphragm ultrasound with without at least 4 months after discharge hospitalization due COVID-19. Results Of 88 evaluated, 34% reported new worsening Demographic characteristics, comorbidities, status were similar fatigued non-fatigued groups. ICU admission during acute phase illness emerged a significant risk factor for (OR 2.65; 95% CI, 1.03–6.94) multivariable analysis. No differences observed lung findings, left ventricular systolic function Fatigue was associated elevated serum levels myostatin irisin, markers muscle metabolism. Additionally, experiencing poorer functional capacity reduced quality life, lower scores multiple domains SF-36 questionnaire, including general health, vitality, mental health. Conclusion Post-COVID-19 strongly prior implicating myopathic its persistence. The profound impact life highlights urgent need further research elucidate pathophysiology develop targeted therapeutic strategies. provides critical insights into interplay organ-specific factors fatigue, offering foundation future interventions improve outcomes long COVID.

Language: Английский

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Investigating the role of organizational stress in nurses' psychosomatic complaints: Evidence from a study in northeastern Italy

AIMS Public Health, Journal Year: 2024, Volume and Issue: 11(2), P. 420 - 431

Published: Jan. 1, 2024

<abstract><sec> <title>Background</title> <p>Nursing is pivotal to healthcare delivery but often associated with high levels of organizational stress. In this cross-sectional study, we aimed investigate the associations between exposure stressors, measured using Health and Safety Executive Management Standards Indicator Tool, psychosomatic complaints among nurses in a medium-sized city hospital northeastern Italy.</p> </sec><sec> <title>Methods</title> <p>A total 215 participated completing self-report questionnaires assessing stressors prevalence experienced over preceding six months.</p> <title>Results</title> <p>Significant were observed various nurses. Specifically, Relationships factor emerged as significant predictor palpitations, irritability, anxiety, physical mental tiredness, headache. Additionally, Demands Managers' support identified predictors specific complaints.</p> <title>Conclusion</title> <p>This study highlights critical role addressing particularly those related interpersonal relationships, promoting nurse well-being optimizing patient care delivery. Despite its strengths, including use well-established measurement tool comprehensive assessment complaints, limitations such design measures warrant consideration. By prioritizing supportive work environments implementing targeted interventions, organizations can cultivate culture nurses, ultimately enhancing quality safety delivery.</p> </sec></abstract>

Language: Английский

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Association between fatigue and depressive symptoms in persons with post-COVID-19 condition: a post hoc analysis

Current Medical Research and Opinion, Journal Year: 2024, Volume and Issue: 40(7), P. 1203 - 1209

Published: June 11, 2024

Objective Post-COVID-19 Condition (PCC) is a prevalent, persistent and debilitating phenomenon occurring three or more months after resolution of acute COVID-19 infection. Fatigue depressive symptoms are commonly reported in PCC. We aimed to further characterize PCC by assessing the relationship between fatigue symptom severity adults with

Language: Английский

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Is recovery just the beginning? Persistent symptoms and health and performance deterioration in post-COVID-19, non-hospitalized university students—a cross-sectional study

Biology Methods and Protocols, Journal Year: 2023, Volume and Issue: 8(1)

Published: Jan. 1, 2023

Many individuals experience persistent symptoms such as deteriorated physical and mental health, increased fatigue, reduced cognitive performance months after recovering from coronavirus disease 2019 (COVID-19). There is limited data on the long-term trajectory prevalence of these symptoms, especially in milder cases. Our study aimed to assess effects COVID-19 a cohort 214 students, averaging 21.8 years age. Of these, 148 had contracted but were not hospitalized, with time since infection ranging 1 39 months. We utilized comprehensive panel tests measure intelligence, memory, psychomotor skills, detailed anamnestic questionnaire evaluate health. While contracting did significantly impact overall health performance, it was associated reports fatigue. However, reported severity pronounced negative influence well-being, reaction time. Trends improvement well error rate, observed within first 2 post-infection. fatigue showed trend deterioration. Beyond 2-year mark, rate continued improve, while began deteriorate. Fatigue decline. Overall, our findings suggest that some can persist or even deteriorate over time, younger who mild cases require hospitalization.

Language: Английский

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Fatigue and somatic symptom burden among U.S. adults with current, previous, or no history of long COVID

Fatigue Biomedicine Health & Behavior, Journal Year: 2024, Volume and Issue: 12(3), P. 205 - 216

Published: March 6, 2024

Objective: Long COVID is associated with many symptoms, including fatigue. As some long report remission of symptoms over time, previous has become increasingly prevalent. This cross-sectional study assessed differences in fatigue and somatic symptom burden among individuals current, previous, no history symptoms.

Language: Английский

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3 Months Follow Up of the Post-COVID Syndrome after Admission in a Specialised Post-COVID Centre – A Prospective Study Focusing Mental Health with Patient Reported Outcome Measures (PROMs)

Published: July 24, 2024

Background and objective: The impairments duration of PASC (Post-acute sequelae COVID-19) symptoms in mental health have up to date not been comprehensively examined. Our objective is provide longitudinal data on the Post-COVID patients identify risk protective factors associated with a severe or prolonged course. Methods: Mental 265 outpatient centre University-Hospital Erlangen was assessed 17.1 (T0) 22.5 months after infection (T1). An online survey validated questionnaires for (Post-COVID-Syndrome-Score), depression (Patient-Health-Questionnaire 9), somatic 15), anxiety (Generalized-Anxiety-Disorder 7), fatigue (Fatigue-Severity-Scale) Post-Exertional Malaise (PEM) (DePaul Post-Exertional-Malaise Screening) conducted home environment. Results: 80% experienced at follow up. Clinically relevant depression, persistent symptoms, anxiety, were reported by 55.8%, 72.5%, 18.9% 89.4% respectively. Depressive, symptom severity decreased significantly over time; PEM remained an unchanged high level. Risk factor higher scores older age; prior psychiatric illness treated psychotherapy more depressive, somatic, symptoms. longer between acute initial presentation centre. Conclusion: findings align previous research, claiming syndrome, lasting infection. In-depth assessment implications needed planning services disease prevention.

Language: Английский

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Fatigue during the COVID-19 pandemic – prevalence and predictors: findings from a prospective cohort study

Stress, Journal Year: 2024, Volume and Issue: 27(1)

Published: May 17, 2024

The COVID-19 pandemic and consequent lockdowns had a substantial impact on mental health. Distress fatigue are highly correlated. However, little is known about the determinants of in general population during pandemic. This study aimed to examine prevalence predictors UK population. Online surveys were completed by community cohort April 2020 (wave 1), July-September 2) November-December 3). In total, 3097 participants wave 1 survey, 1385 1087 (85.4% women) 2 3 respectively. Fatigue was assessed using Chalder Scale at waves 3. Hair samples provided 827 (90.6% 2, which analyzed indicate HairE (stress hormone). mean total score 14.7 (SD = 4.7), significantly higher than pre-pandemic levels observed (mean difference 0.50, p .003). At 614 (44.3%) met case definition for fatigue, only 15.6% whom indicated that lasted more 6 months (suggesting it started prior pandemic). Predictors included being risk group, depression belief having COVID-19, explained 23.8% variability scores. Depression significant predictor remaining prevalent limited people's daily function. sociodemographic variables fatigue.

Language: Английский

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Long COVID symptoms and demographic associations: A retrospective case series study using healthcare application data

JRSM Open, Journal Year: 2024, Volume and Issue: 15(7)

Published: July 1, 2024

Objectives To investigate long COVID (LC) symptoms self-reported via a digital application. Explore associations between various demographic factors and intensity of LC symptoms. Design A retrospective case series study. We analysed from 1008 individuals with November 30, 2020, March 23, 2022. Setting England Wales. Participants Individuals using the healthcare application in 31 post-COVID-19 clinics self-reporting Main outcome measures Highest reported symptoms, Results 109 symptom categories were identified, pain (26.5%), neuropsychological issues (18.4%), fatigue (14.3%) dyspnoea (7.4%) most prevalent. The increased by 3.3% per month since registration. Age groups 68–77 78–87 experienced higher (32.8% 86% higher, respectively) compared to 18–27 age group. Women 9.2% more intense than men, non-white 23.5% white LC. Higher education levels (national vocational qualification (NVQ) 3 NVQ 5) associated less (27.7%, 62.8% 44.7% less, least educated (NVQ 1–2). People deprived areas had those area. No significant association was found index multiple deprivation (IMD) decile number Conclusion Treatment plans must prioritise addressing prevalent symptoms; we recommend sustained support for clinics. Demographic significantly influence severity, underlining need targeted interventions. These findings can inform policies better manage

Language: Английский

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