The Journals of Gerontology Series A, Journal Year: 2024, Volume and Issue: 79(8)
Published: June 26, 2024
Language: Английский
Biomolecules, Journal Year: 2025, Volume and Issue: 15(2), P. 161 - 161
Published: Jan. 22, 2025
Early life adversity (ELA) has long been recognized to negatively impact a variety of health outcomes, with increasingly long-term implications for neurocognitive function. ELA may affect the brain through multiple mechanisms, including chronic inflammation. One potential moderator pathway from neuroinflammation cognitive dysfunction is sex. leave females potentially even more vulnerable impairment in later life. This review discusses influence on function across much lifespan, how inflammation implicated this process, and current state knowledge regarding sex differences these relationships. We conclude discussion unanswered questions suggestions future research, incorporation genetic data.
Language: Английский
Citations
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PLoS ONE, Journal Year: 2025, Volume and Issue: 20(3), P. e0311074 - e0311074
Published: March 27, 2025
Background Dementia is a major public health concern, with its incidence rising as the population ages. Recent studies suggest links between childhood health, socioeconomic status, and later-life cognitive impairment dementia, though findings remain inconclusive. This systematic review evaluates influence of status on dementia. Method A search conducted in MEDLINE, CiNAHL, PsycINFO December 2024 identified 44 matching our inclusion criteria. Findings are presented under five key themes: (1) (2) educational attainment, (3) family factors, (4) experiences, (5) reading habits social interactions. Conclusion Our results highlight need for further longitudinal to establish causal relationships early-life risk factors later decline. Policymakers should prioritize early development programs that integrate nutrition, education, support help mitigate dementia life.
Language: Английский
Citations
0
Alzheimer s & Dementia, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 6, 2024
Abstract INTRODUCTION Childhood adversity harms neurodevelopment. Literature on late‐life brain health is limited, and findings cognition are mixed. METHODS Pooling data from Kaiser Healthy Aging Diverse Life Experiences (KHANDLE) Study of in African Americans (STAR) cohorts, we assessed the impact childhood (factor score seven self‐reported items) (a) executive function verbal memory decline using linear mixed effects models ( n = 2447), (b) structural magnetic resonance imaging (MRI) regression 618), (c) amyloid positron emission tomography (PET) generalized 331), all adjusting for early‐life demographic socioeconomic confounders. RESULTS was not associated with except a slightly faster −0.013 SD/year, 95% confidence interval [−0.025, −0.001]). Among neuroimaging outcomes, only larger temporal lobe volumes 0.092 SD [0.012, 0.173]). DISCUSSION More research evaluating sources resilience, heterogeneity, bias needed to explain inconsistent across studies. Highlights We developed measurement capture diverse cohort. decline. examined adversity's effect MRI PET measures. Higher volumes.
Language: Английский
Citations
1
American Journal of Epidemiology, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 27, 2024
Abstract Trauma, defined as exposure to actual or threatened death, serious injury, sexual violence, is a pervasive, major public health challenge that disproportionately burdens socially disadvantaged groups and has known consequences for outcomes in early midlife. Despite plausible mechanisms by which trauma may also be critically important risk factor late life, there presently lack of literature evaluating the on aging-related inequities, such dementia. In this commentary, we (1) discuss drivers paucity epidemiologic evidence namely available data, supported detailed review measures, including interpersonal violence—a particularly common form trauma—in 7 established longitudinal aging cohort studies United States; (2) address 4 concerns about inclusion measures studies; (3) suggest ways forward, specific assessment tools measure violence after structured PhenX Toolkit, facilitate critical research understand impact life.
Language: Английский
Citations
0
The Journals of Gerontology Series A, Journal Year: 2024, Volume and Issue: 79(8)
Published: June 26, 2024
Language: Английский
Citations
0