How to understand the overlap of long COVID, chronic fatigue syndrome/myalgic encephalomyelitis, fibromyalgia and irritable bowel syndromes

Seminars in Arthritis and Rheumatism, Journal Year: 2024, Volume and Issue: 67, P. 152455 - 152455

Published: May 7, 2024

Language: Английский

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Identifying people with post-COVID condition using linked, population-based administrative health data from Manitoba, Canada: prevalence and predictors in a cohort of COVID-positive individuals

BMJ Open, Journal Year: 2025, Volume and Issue: 15(1), P. e087920 - e087920

Published: Jan. 1, 2025

Objective Many individuals exposed to SARS-CoV-2 experience long-term symptoms as part of a syndrome called post-COVID condition (PCC). Research on PCC is still emerging but urgently needed support diagnosis, clinical treatment guidelines and health system resource allocation. In this study, we developed method identify cases using administrative data report prevalence predictive factors in Manitoba, Canada. Design Cohort study. Setting Participants All Manitobans who tested positive for during population-wide PCR testing from March 2020 December 2021 (n=66 365) were subsequently deemed have based International Classification Disease-9/10 diagnostic codes prescription drug (n=11 316). Additional identified modelling assess patterns service use, including physician visits, emergency department visits hospitalisation any reason (n=4155). Outcomes We measured % among with tests associated by calculating odds ratios 95% confidence intervals, adjusted sociodemographic characteristics (aOR). Results Among 66 365 tests, 15 471 (23%) having PCC. Being female (aOR 1.64, CI 1.58 1.71), being age 60–79 1.33, 1.25 1.41) or 80+ 1.62, 1.46 1.80), hospitalised within 14 days COVID-19 infection 1.95, 1.80 2.10) Charlson Comorbidity Index 1+ 1.78 2.14) Receiving doses the vaccine (one dose, aOR 0.80, 0.74 0.86; two doses, 0.29, 0.22 0.31) decreased Conclusions This data-driven approach expands our understanding epidemiology may be applied other jurisdictions population-based data. The study provides additional insights into risk protective inform planning delivery.

Language: Английский

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Post-Recovery Mental Health Outcomes in Young Adults with Mild-to-Moderate COVID-19: A Cross-Sectional Study

COVID, Journal Year: 2025, Volume and Issue: 5(2), P. 27 - 27

Published: Feb. 19, 2025

Background: The long-term effects of COVID-19 infection represent an emerging area research that explores the relationships between a history and its consequential sequelae. This study investigates potential associations among time since infection, severity acute phase disease, sex, while controlling for age, in relation to mental health. Methods: A total 305 university students participated this cross-sectional study, during which data were collected using SCL-90-R questionnaire. analysis was conducted MANCOVA, ANCOVA, partial Kendall’s Tau methods. Results: findings indicated factors such as sex—specifically being female—longer elapsed disease significantly influenced multiple scales SCL-90-R. Conclusions: Based on these findings, it is recommended investigations into health issues consider biological severity, risk young adults with infection.

Language: Английский

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Cost-effectiveness of preventive COVID-19 interventions: a systematic review and network meta-analysis of comparative economic evaluation studies based on real-world data

Journal of Global Health, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 20, 2025

There is a knowledge gap regarding the effectiveness and utility of various preventive interventions during COVID-19 pandemic. In this study, we aimed to evaluate cost-effectiveness interventions, including non-medical (NMIs) vaccination programs, using real-world data across different demographic socioeconomic contexts worldwide. We searched Medline, Cochrane Library, Embase, Web Science Core Collection from December 2019 March 2024. identified 75 studies which compared 34 interventions. conducted network meta-analysis assess incremental net benefits (INB) these both societal health care system perspectives. adjusted purchasing power parity (PPP) standardised willingness pay (WTP) enhance comparability economic levels. performed sensitivity subgroup analyses examine robustness results. Movement restrictions expanding testing emerged as most cost-effective strategies perspective, with WTP-standardised INB values USD 21 050 11 144. contrast, combinations NMIs were less cost-effective, particularly in high-income regions. From plus distancing test, trace, isolate strategy highly while masking requirements economically viable. The varied significantly contexts, underlining necessity for region-specific strategies. highlight significant variations Tailoring specific regional infrastructural conditions crucial. Continuous evaluation adaptation are essential effective management ongoing future public threats. PROSPERO: CRD42023385169.

Language: Английский

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Mental Health in the Time of the COVID-19 Pandemic: A Scoping Review of Collateral Effects on Common Mental Disorders (CMDs)

International Journal of Environmental Research and Public Health, Journal Year: 2025, Volume and Issue: 22(4), P. 478 - 478

Published: March 23, 2025

It is unclear whether the COVID-19 pandemic has had consequences for common mental disorders (CMDs). This scoping review aims to examine direct infection-related (e.g., severe illness), psychosocial social isolation), and indirect outcomes changes in incidence) that have been particularly discussed so far. A literature search clinically diagnosed adult CMDs was conducted using Pubmed, Web of Science, PsycInfo (n = 5325). After completion screening process, 26 included studies remained extraction. None reported post-pandemic data. The effects appeared be pronounced anxiety obsessive-compulsive first year pandemic. followed by a period adjustment, during which rates disease its symptoms largely returned pre-pandemic levels. Fluctuating may COVID-related causes. Preventive temporary inpatient care could protective approach those at risk or vulnerable, as well establishing consultation building resilience. gap research lack comparisons CMD data before, during, after distinguish transient from chronic requiring treatment.

Language: Английский

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Course of neuropsychological health in post-COVID patients differs 6 and 12 months after inpatient rehabilitation

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 16

Published: April 25, 2025

Background Rehabilitation is an effective and feasible approach for post-COVID patients to improve mental health cognitive complaints. However, knowledge regarding the long-term impact of rehabilitation on neuropsychological these lacking. Objective This study aims investigate psychological health, fatigue, function 6 12 months after inpatient patients, who acquired COVID-19 in workplace. In addition, group differences outcome parameters according sex, age, acute COVID status, socioeconomic profession, pre-existing diseases will be detected. Methods longitudinal observational examined changes 127 with as occupational disease or work accident. Symptoms depression anxiety, fatigue severity, somatic symptom trauma-related symptoms, functioning were assessed at beginning well six rehabilitation. Group concerning existing prior also analyzed. Results The results showed that improvements direct severity could not maintained discharge. Contrary, patients’ stable during follow-up. Significant observed diseases. Conclusion highlights importance aftercare process implementation adequate individualized therapeutic interventions such support strengthen self-management skills. registered German Clinical Trials Register identifier DRKS00022928.

Language: Английский

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Effects of ACE inhibitor/ARB therapy and long COVID on kidney disease: a retrospective cohort study using real-world data

Clinical Kidney Journal, Journal Year: 2024, Volume and Issue: 17(7)

Published: June 7, 2024

The association between angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) and severe acute respiratory syndrome coronavirus 2 susceptibility, particularly via ACE-2 upregulation in the kidneys, raises concerns about potential kidney disease risks long (COVID) patients. This study explores of ACEI/ARB therapy on injury (AKI), chronic (CKD) all-cause mortality patients with without COVID. A retrospective cohort using TriNetX datasets was conducted, diagnoses COVID International Classification Diseases, Tenth Revision (ICD-10) codes prescription for as classification four cohorts: users (LCAUs), non-users (LCANs), non-long (NLCAUs) (NLCANs). Multivariable stratified Cox proportional hazards regression models assessed adjusted hazard ratios (aHRs) across groups. Additional analyses were including time-dependent exposure analysis comparison an active comparator, calcium channel blockers. Our included 18 168 181 680 propensity score-matched from October 2021 to 2023. use did not significantly affect risk AKI CKD when comparing LCAUs LCANs NLCAUs NLCANs. However, a protective effect against observed {aHR 0.79 [95% confidence interval (CI) 0.65-0.93]} NLCAU group compared NLCAN group. Conversely, associated increased [aHR 1.49 (95% CI 1.03-2.14)] 1.00-2.23)] additional support primary findings. treatment does increase incidence AKI, regardless status. itself is increasing diseases mortality.

Language: Английский

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The association between prolonged SARS-CoV-2 symptoms and work outcomes

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(7), P. e0300947 - e0300947

Published: July 29, 2024

While the early effects of COVID-19 pandemic on United States labor market are well-established, less is known about long-term impact SARS-CoV-2 infection and Long COVID employment. To address this gap, we analyzed self-reported data from a prospective, national cohort study to estimate symptoms at three months post-infection missed workdays return work. The analysis included 2,939 adults in Innovative Support for Patients with Infections Registry (INSPIRE) who tested positive their initial time enrollment, were employed before pandemic, completed baseline three-month electronic survey. At post-infection, 40.8% participants reported least one symptom 9.6% five or more symptoms. When asked work due months, 7.2% missing ≥10 13.9% not returning since infection. ≥5 had higher adjusted odds ratio (2.96, 95% CI 1.81–4.83) (2.44, 1.58–3.76) compared those no Prolonged common, affecting 4-in-10 three-months associated increased loss, most pronounced among months. Despite end federal Public Health Emergency efforts “return normal”, policymakers must consider clinical economic implications people’s employment status absenteeism, particularly as characterizing numerous health well-being impacts continue emerge. Improved understanding risk factors lost may guide support people

Language: Английский

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Ribavirin’s Daily Dose Growth Determined as the Result of Medicament Testing May Be a Predictor of the Chronic Course of the Disease in Long COVID Syndrome Patients

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: March 19, 2024

Abstract Introduction Long COVID syndrome, a multisystemic condition resulting from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, affects at least 65 million people worldwide. The disease pathogenesis is unclear, and many different assumptions still exist. This study aimed to explore the use of medicament testing determine optimal daily dose ribavirin through electroacupuncture via Voll (EAV) diagnostic system for acupuncture points. Materials methods One hundred one patients (aged 16 50) with long were recruited Research Institute Virology eligible according inclusion criteria. Patients randomized experimental or placebo groups. further examined EAV diagnostics based on level electrodermal activity points, followed by (tablets) doses drug. Fifty-two participants group fourty nine considered data analyses. Results results this demonstrated feasibility using identify meridians decreased levels restore conductivity studied points measure Conclusions measured in may indirectly serve as prognostic marker course disease. However, clinical instrumental studies are needed evaluate application assessing long-term syndrome.

Language: Английский

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Does COVID-19 Increase the Risk of Subsequent Kidney Diseases More Than Influenza? A Retrospective Cohort Study Using Real-World Data In the United States

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 28, 2024

Abstract Background Although case reports and observational studies suggest Coronavirus disease 2019 (COVID-19) increases the risk of kidney diseases, definitive real-world evidence, especially in comparison with influenza, is lacking. Our study aims to assess association between COVID-19 infections subsequent using influenza as a positive control incorporating negative establish clearer associations. Methods A large retrospective cohort strata matching was conducted MarketScan database records from Jan. 2020 Dec. 2021. We used international classification 10th revision (ICD-10) codes identify individuals build three cohorts, (1) group, index dates diagnosis COVID-19; (2) Influenza but no (positive control) Influenza; (3) / (negative randomly assigned The main outcomes were acute injury (AKI), chronic (CKD), end-stage renal (ESRD). To evaluate new onset diseases relative both groups, we employed multivariable stratified Cox proportional hazards regression analysis. Results included 939,241 COVID-19, 1,878,482 199,071 influenza. After adjusting for demographics, comorbidities, medication histories, significantly associated increased risks AKI (adjusted ratio, aHR: 2.74, 2.61-2.87), CKD (aHR: 1.38, 1.32-1.45), ESRD (aHR, 3.22; 95% CI, 2.67-3.88), while modestly 1.24, 1.11-1.38) had impact on 1.03, 0.92-1.14), 0.84; 0.55-1.29). Time-specific analyses indicated that HR declined 0-180 days 0-540 days, remained stable, COVID-19’s surpassing influenza’s throughout follow-up. Exploratory analysis also found significant impacts glomerular (aHR 1.28, CI 1.09-1.50). Conclusion In this study, 2.3-fold developing AKI, 1.4-fold CKD, 4.7-fold compared Greater attention needs be paid after contracting prevent future adverse health outcomes.

Language: Английский

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