Variability in Arterial Stiffness and Vascular Endothelial Function After COVID-19 During 1.5 Years of Follow-Up—Systematic Review and Meta-Analysis
Life,
Journal Year:
2025,
Volume and Issue:
15(4), P. 520 - 520
Published: March 21, 2025
Increasing
long-term
observations
suggest
that
coronavirus
disease
2019
(COVID-19)
vasculopathy
may
persist
even
1.5
years
after
the
acute
phase,
potentially
accelerating
development
of
atherosclerotic
cardiovascular
diseases.
This
study
systematically
reviewed
variability
brachial
flow-mediated
dilation
(FMD)
and
carotid-femoral
pulse
wave
velocity
(cfPWV)
from
phase
COVID-19
through
16
months
follow-up
(F/U).
Databases
including
PubMed,
Web
Science,
MEDLINE,
Embase
were
screened
for
a
meta-analysis
without
language
or
date
restrictions
(PROSPERO
reference
CRD42025642888,
last
search
conducted
on
1
February
2025).
The
quality
included
studies
was
assessed
using
Newcastle–Ottawa
Quality
Scale.
We
considered
all
(interventional
pre-post
studies,
prospective
observational
randomized,
non-randomized
trials)
FMD
cfPWV
in
adults
(aged
≥
18
years)
with
laboratory-confirmed
compared
non-COVID-19
controls
changes
these
parameters
during
F/U.
Twenty-one
reported
differences
FMD,
examined
between
patients
control
groups
various
stages:
acute/subacute
(≤30
days
onset),
early
(>30–90
days),
mid-term
(>90–180
late
(>180–270
very
(>270
days)
post-COVID-19
recovery.
Six
while
nine
did
so
Data
14
(627
cases
694
controls)
15
(578
703
our
meta-analysis.
showed
significant
decrease
to
(standardized
mean
difference
[SMD]=
−2.02,
p
<
0.001),
partial
improvements
noted
recovery
(SMD
=
0.95,
0.001)
0.92,
0.006).
Normalization
observed
0.12,
0.69).
In
contrast,
values,
which
higher
than
1.27,
remained
elevated
throughout
F/U,
no
except
(SMD=
−0.39,
0.001).
recovery,
values
those
0.45,
0.010).
manuscript,
we
discuss
how
factors,
severity
COVID-19,
persistence
syndrome,
patient’s
initial
vascular
age,
depending
metrics
age
risk
influenced
time
degree
improvement.
Language: Английский
Approach for enhancing the accuracy of semantic segmentation of chest X-ray images by edge detection and deep learning integration
Frontiers in Artificial Intelligence,
Journal Year:
2025,
Volume and Issue:
8
Published: April 16, 2025
Introduction
Accurate
segmentation
of
anatomical
structures
in
chest
X-ray
images
remains
challenging,
especially
for
regions
with
low
contrast
and
overlapping
structures.
This
limitation
significantly
affects
the
diagnosis
cardiothoracic
diseases.
Existing
deep
learning
methods
often
struggle
preserving
structural
boundaries,
leading
to
artifacts.
Methods
To
address
these
challenges,
I
propose
a
novel
approach
that
integrates
contour
detection
techniques
U-net
architecture.
Specifically,
method
employs
Sobel
Scharr
edge
filters
enhance
boundaries
before
segmentation.
The
pipeline
involves
pre-processing
using
detection,
followed
by
model
trained
identify
lungs,
heart,
clavicles.
Results
Experimental
evaluation
demonstrated
edge-enhancing
filters,
particularly
operator,
leads
marked
improvement
accuracy.
For
lung
segmentation,
achieved
an
accuracy
99.26%,
Dice
coefficient
98.88%,
Jaccard
index
97.54%.
Heart
results
included
99.47%
94.14%
index,
while
clavicle
reached
99.79%
89.57%
index.
These
consistently
outperform
baseline
without
enhancement.
Discussion
integration
improves
quality
complex
X-rays.
Among
tested
operator
proved
be
most
effective
enhancing
boundary
information
reducing
offers
promising
direction
more
accurate
robust
computer-aided
systems
radiology.
Language: Английский