Physical activity, cathepsin B, and cognitive health

Trends in Molecular Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

The Impact of Walking on BDNF as a Biomarker of Neuroplasticity: A Systematic Review

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(3), P. 254 - 254

Published: Feb. 27, 2025

Background/Objectives: The brain-derived neurotrophic factor (BDNF) is a critical exercise-induced modulator of various neuroplasticity processes, including adult hippocampal neurogenesis. Environmental affordance for physical activity novel theory that aims to increase the BDNF through walking or climbing stairs, stimulated by urban and interior environment. In systematic review, this paper explores association between walking, as structured free-living form activity, changes in humans with healthy locomotion. Method: A review registered protocol, INPLASY2024110093, following PRISMA guidelines, includes English-language original research articles on older human subjects who are locomotor-healthy, studies exercise presented non-combined intervention, must report dependent variable. search was conducted using three databases: PubMed, Web Science, Scopus, resulting 21 eligible studies. Results: This finds impact evidenced, but subject moderate high intensities single bouts. At same time, long-term effects yet be fully understood, potentially due uptake functional brain improvements, muscle repair, instead an accumulation itself, still confirm important role neurosustainability. Age environmental factors such heat also found affect BDNF. narrative synthesis provides elaborate explanations understanding those complex dynamics before reaching future conclusions concentrations. Conclusions: highlights potential played moderate- high-intensity lifestyle intervention can utilised built environment promote adaptive changes, sustainable regulation

Language: Английский

Exercise, Neuroprotective Exerkines, and Parkinson’s Disease: A Narrative Review

Biomolecules, Journal Year: 2024, Volume and Issue: 14(10), P. 1241 - 1241

Published: Sept. 30, 2024

Parkinson's disease (PD) is a prevalent neurodegenerative in which treatment often includes an exercise regimen. Exercise neuroprotective animal models of PD, and, more recently, human clinical studies have verified exercise's disease-modifying effect. Aerobic and resistance training improve many PD's motor non-motor symptoms, while neuromotor therapy stretching/flexibility exercises positively contribute to the quality life people with PD. Therefore, understanding role managing this complex disorder crucial. Exerkines are bioactive substances that synthesized released during been implicated several positive health outcomes, including neuroprotection. protect neuronal cells vitro rodent PD vivo. both increase exerkine levels blood, suggesting for exerkines theory. Many demonstrate potential protecting brain against pathological missteps caused by Every person (people) (PwP) needs comprehensive plan tailored their unique abilities. Here, we provide template help PwP understand importance treating describe barriers confronting attempt exercise, suggestions overcoming these barriers, explore In conclusion, together create powerful system should slowing chronic progression

Language: Английский