Imbalance in gut microbial interactions as a marker of health and disease DOI Creative Commons
Roberto Corral López, Juan A. Bonachela, María Gloria Domínguez-Bello

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

Imbalances in the human gut microbiome (dysbioses) are linked to multiple diseases but remain poorly understood. Current biomarkers identify dysbiosis inconsistent and fail capture ecological mechanisms differentiating healthy from diseased microbiomes. We propose a general biomarker, inspired by phenomenology observed gut-microbiome theoretical model introduced here. The emergent communities show complex interaction networks two distinct collective states, corresponding dysbiotic Our robust metric for dysbiosis, quantifying balance between cooperation competition, differentiates these states both simulated real datasets across diverse diseases. Moreover, it reveals that results shift toward greater community. further correlates with disease progression, highlighting its potential as diagnostic tool.

Language: Английский

Imbalance in gut microbial interactions as a marker of health and disease DOI Creative Commons
Roberto Corral López, Juan A. Bonachela, María Gloria Domínguez-Bello

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

Imbalances in the human gut microbiome (dysbioses) are linked to multiple diseases but remain poorly understood. Current biomarkers identify dysbiosis inconsistent and fail capture ecological mechanisms differentiating healthy from diseased microbiomes. We propose a general biomarker, inspired by phenomenology observed gut-microbiome theoretical model introduced here. The emergent communities show complex interaction networks two distinct collective states, corresponding dysbiotic Our robust metric for dysbiosis, quantifying balance between cooperation competition, differentiates these states both simulated real datasets across diverse diseases. Moreover, it reveals that results shift toward greater community. further correlates with disease progression, highlighting its potential as diagnostic tool.

Language: Английский

Citations

0