Association of free triiodothyronine and total triiodothyronine with nonalcoholic fatty liver disease: from National Health and Nutrition Examination Survey and Mendelian randomization study DOI

Wei Hao,

Lanlan Chen, Ting Li

et al.

European Journal of Gastroenterology & Hepatology, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Background Nonalcoholic fatty liver disease (NAFLD) is associated with multiple factors, yet the relationship between NAFLD and thyroid-related biomarkers remains unclear. This study aims to elucidate this potential linkage. Methods Utilizing data from US National Health Nutrition Examination Survey (NHANES), we explored possible associations through multivariable logistic regression, subgroup analysis, interaction tests. A bidirectional Mendelian randomization (MR) approach complemented by various sensitivity analyses was then employed ascertain these relationships’ causality. Results Our NHANES analysis indicated significant elevated levels of free triiodothyronine (FT3) [odds ratio (OR): 2.59, 95% confidence interval (CI): 1.50–4.49] total (TT3) (OR: 2.01, CI: 1.27–3.18) prevalence NAFLD. MR findings reinforced causal relationship, demonstrating that may elevate FT3 ( β : 0.05, 0.01–0.09) TT3 0.08, 0.02–0.14) levels. Additionally, thyroid-stimulating hormone (TSH) confirmed as an independent risk factor for 1.10, 1.04–1.18), specific supporting robustness results. Conclusion indicates elevations in FT3, TT3, thyroglobulin NAFLD, while also identifying TSH a These underscore importance routine thyroid function monitoring both general population particularly individuals

Language: Английский

The Lipidomic Profile Discriminates Between MASLD and MetALD DOI Creative Commons
Kai Markus Schneider, Feng Cao, Helen Huang

et al.

Alimentary Pharmacology & Therapeutics, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

ABSTRACT Background The recent consensus statement redefined steatotic liver diseases. Metabolic dysfunction‐associated disease (MASLD) and metabolic dysfunction alcohol‐related (MetALD) now represent distinct entities. However, biomarkers that differentiate MASLD MetALD remain largely unknown. Aims To identify lipidomic with discriminatory potential for distinguishing from MASLD. Methods Using the UK Biobank dataset, 40,534 people available MRI scans were analysed. A total of, 11,217 cases a proton density fat fraction (PDFF) ≥ 5% identified as having disease. Among these, profiles obtained 5539 462 cases. 250 plasma metabolomic parameters Mendelian randomisation (MR) analysis was used to confirm association between alcohol consumption biomarkers. Results When comparing top 30 differentially expressed predicting compared MASLD, majority related HDL significantly overrepresented at both analysed time points. five metabolites were: acetoacetate, 3‐hydroxybutyrate, phospholipids in Large HDL, concentration of large particles, free cholesterol HDL. sensitivity revealed similar associations, suggesting signature is stable over time. Additionally, MR further confirmed associated increased levels HDL‐related metabolites. Conclusion Our findings indicate HDL‐centric markers, particularly those within larger medium subfraction, may Further longitudinal experimental studies are warranted validate these assess their clinical implications.

Language: Английский

Citations

2
Attention to the misuse of Mendelian randomisation in medical research DOI Creative Commons
Lanlan Chen, Adrien Guillot, Carolin V. Schneider

et al.

eGastroenterology, Journal Year: 2025, Volume and Issue: 3(1), P. e100187 - e100187

Published: Feb. 1, 2025

Language: Английский

Citations

0
Examining the link between 179 lipid species and 7 diseases using genetic predictors DOI Creative Commons
Linda Ottensmann, Rubina Tabassum, Sanni Ruotsalainen

et al.

EBioMedicine, Journal Year: 2025, Volume and Issue: 114, P. 105671 - 105671

Published: March 30, 2025

Language: Английский

Citations

0
Association of free triiodothyronine and total triiodothyronine with nonalcoholic fatty liver disease: from National Health and Nutrition Examination Survey and Mendelian randomization study DOI

Wei Hao,

Lanlan Chen, Ting Li

et al.

European Journal of Gastroenterology & Hepatology, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Background Nonalcoholic fatty liver disease (NAFLD) is associated with multiple factors, yet the relationship between NAFLD and thyroid-related biomarkers remains unclear. This study aims to elucidate this potential linkage. Methods Utilizing data from US National Health Nutrition Examination Survey (NHANES), we explored possible associations through multivariable logistic regression, subgroup analysis, interaction tests. A bidirectional Mendelian randomization (MR) approach complemented by various sensitivity analyses was then employed ascertain these relationships’ causality. Results Our NHANES analysis indicated significant elevated levels of free triiodothyronine (FT3) [odds ratio (OR): 2.59, 95% confidence interval (CI): 1.50–4.49] total (TT3) (OR: 2.01, CI: 1.27–3.18) prevalence NAFLD. MR findings reinforced causal relationship, demonstrating that may elevate FT3 ( β : 0.05, 0.01–0.09) TT3 0.08, 0.02–0.14) levels. Additionally, thyroid-stimulating hormone (TSH) confirmed as an independent risk factor for 1.10, 1.04–1.18), specific supporting robustness results. Conclusion indicates elevations in FT3, TT3, thyroglobulin NAFLD, while also identifying TSH a These underscore importance routine thyroid function monitoring both general population particularly individuals

Language: Английский

Citations

0