Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
16
Published: March 17, 2025
Antimicrobial
resistance
(AMR)
has
become
a
major
and
escalating
global
health
threat,
undermining
the
effectiveness
of
current
antibiotic
antimicrobial
therapies.
The
rise
multidrug-resistant
bacteria
led
to
increasingly
difficult-to-treat
infections,
resulting
in
higher
morbidity,
mortality,
healthcare
costs.
Tackling
this
crisis
requires
development
novel
agents,
optimization
therapeutic
strategies,
initiatives
infection
surveillance
control.
Recent
studies
highlight
crucial
role
human
gut
microbiota
defending
against
AMR
pathogens.
A
balanced
protects
body
through
mechanisms
such
as
colonization
resistance,
positioning
it
key
ally
fight
AMR.
In
contrast,
dysbiosis
disrupts
defense,
thereby
facilitating
persistence,
colonization,
dissemination
resistant
This
review
will
explore
how
influence
drug-resistant
bacterial
its
involvement
various
types
AMR-related
potential
for
microbiota-targeted
therapies,
fecal
transplantation,
prebiotics,
probiotics,
phage
therapy.
Elucidating
interactions
between
pathogens
provide
critical
insights
developing
strategies
prevent
treat
infections.
While
previous
reviews
have
focused
on
general
impact
health,
specifically
look
at
latest
research
evolution
spread
AMR,
highlighting
strategies.
Computational and Structural Biotechnology Journal,
Journal Year:
2025,
Volume and Issue:
27, P. 1482 - 1497
Published: Jan. 1, 2025
Functional
redundancy
has
been
hypothesised
to
be
at
the
core
of
well-evidenced
relation
between
high
ecological
microbiome
diversity
and
human
health.
Here,
we
conceptualise
operationalise
functional
on
a
single-trait
level
for
functionally
annotated
microbial
communities,
utilising
an
information-theoretic
approach
based
relative
entropy
that
also
allows
quantification
interdependency
across
species.
Via
constraint-based
community
modelling
public
faecal
metagenomic
dataset,
demonstrate
strength
species
is
dependent
specific
attributes
function
under
consideration
such
as
rarity
occurring
interdependencies.
Moreover,
by
integrating
metabolome
data,
highlight
measures
have
correlates
in
host's
metabolome.
We
further
microbiomes
sampled
from
colorectal
cancer
patients
display
higher
levels
species-species
interdependencies
than
those
healthy
controls.
By
analysing
models
inflammatory
bowel
disease
(IBD)
study,
show
although
decreased
IBD
subjects,
increased
certain
metabolites,
notably
hydrogen
sulphide.
This
finding
highlights
their
potential
provide
valuable
insights
beyond
diversity.
formalise
concept
communities
its
usefulness
real
providing
foundation
deeper
understanding
how
shapes
capacities
microbiome.
Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
16
Published: March 17, 2025
Antimicrobial
resistance
(AMR)
has
become
a
major
and
escalating
global
health
threat,
undermining
the
effectiveness
of
current
antibiotic
antimicrobial
therapies.
The
rise
multidrug-resistant
bacteria
led
to
increasingly
difficult-to-treat
infections,
resulting
in
higher
morbidity,
mortality,
healthcare
costs.
Tackling
this
crisis
requires
development
novel
agents,
optimization
therapeutic
strategies,
initiatives
infection
surveillance
control.
Recent
studies
highlight
crucial
role
human
gut
microbiota
defending
against
AMR
pathogens.
A
balanced
protects
body
through
mechanisms
such
as
colonization
resistance,
positioning
it
key
ally
fight
AMR.
In
contrast,
dysbiosis
disrupts
defense,
thereby
facilitating
persistence,
colonization,
dissemination
resistant
This
review
will
explore
how
influence
drug-resistant
bacterial
its
involvement
various
types
AMR-related
potential
for
microbiota-targeted
therapies,
fecal
transplantation,
prebiotics,
probiotics,
phage
therapy.
Elucidating
interactions
between
pathogens
provide
critical
insights
developing
strategies
prevent
treat
infections.
While
previous
reviews
have
focused
on
general
impact
health,
specifically
look
at
latest
research
evolution
spread
AMR,
highlighting
strategies.
