Cancers,
Journal Year:
2025,
Volume and Issue:
17(2), P. 202 - 202
Published: Jan. 9, 2025
Approximately
36%
of
patients
with
cervical
cancer
present
regional
nodal
metastasis
at
diagnosis,
which
is
associated
adverse
survival
outcomes
after
definitive
treatment.
In
the
modern
era
chemoradiotherapy
(CRT)
and
image-guided
adaptive
brachytherapy
(IGABT),
where
excellent
local
control
achieved
for
locally
advanced
(LACC),
failure
remains
a
major
challenge
to
cure.
To
optimize
treatment
node-positive
LACC
reduce
incidence
failure,
various
approaches
have
been
explored,
including
methods
surgical
staging
or
dissection,
RT
dose
escalation
strategies,
such
as
intensity-modulated
radiotherapy
(IMRT)
simultaneous
integrated
boost
(SIB)
involved
nodes,
elective
subclinical
para-aortic
(PAO)
disease.
Additionally,
there
growing
interest
in
emerging
precision
techniques,
magnetic
resonance-guided
(MRgRT)
proton
therapy,
may
allow
further
improvement
therapeutic
ratio.
This
review
outlines
detection
metastasis,
options
LACC,
techniques
their
clinical
evidence
efficacy
toxicity
profiles.
Furthermore,
recent
advances
systemic
therapy
promising
novel
directions
that
shape
management
are
discussed.
BMC Cancer,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: Jan. 22, 2025
Abstract
Background
Effective
diagnostic
tools
for
prompt
identification
of
high-risk
locally
advanced
cervical
cancer
(LACC)
patients
are
needed
to
facilitate
early,
individualized
treatment.
The
aim
this
work
was
assess
temporal
changes
in
tumor
radiomics
(delta
radiomics)
from
T2-weighted
imaging
(T2WI)
during
concurrent
chemoradiotherapy
(CCRT)
LACC
patients,
and
their
association
with
progression-free
survival
(PFS).
Furthermore,
develop,
validate,
compare
delta-
pretreatment
radiomic
signatures
prognostic
modeling.
Methods
A
total
110
undergoing
CCRT
MRI
at
baseline
mid-treatment
were
divided
into
training
(cohort
T
:
n
=
73)
validation
V
37)
cohorts.
Radiomic
features
extracted
tumors
segmented
on
pre-CCRT
mid-CCRT
T2WI
deltas
features)
computed.
Two
predicting
PFS
constructed
by
least
absolute
shrinkage
selection
operator
(LASSO)
Cox
regression:
Delta
rad
(from
delta
Pre-CCRT
features).
Prognostic
performance
the
signatures,
2018
International
Federation
Gynecology
Obstetrics
(FIGO)
stage
(I–IV),
MRI-derived
maximum
diameter
(Tumor
max
≤2
cm;
>2
≤
4
>4
cm)
evaluated
area
under
time-dependent
receiver
operating
characteristics
(tdROC)
curves
(AUC)
cohort
(AUC
/AUC
).
Mann–Whitney
U
tests
assessed
differences
features.
using
Kaplan–Meier
method
log-rank
tests.
Results
0.74/0.79)
marginally
outperformed
(0.72/0.75)
5-year
PFS,
both
clearly
surpassed
that
FIGO
(0.61/0.61)
Tumor
(0.58/0.65).
In
total,
four
within
significantly
differed
feature
values
between
progressors
non-progressors,
being
consistently
lower
(
p
0.03
all).
High
scores
associated
poor
0.04
/Pre-CCRT
cohorts;
0.11
Conclusions
Delta-
equally
allow
early
prognostication
LACC,
outperforming
MRI-assessed
diameter.
International Journal of General Medicine,
Journal Year:
2025,
Volume and Issue:
Volume 18, P. 881 - 895
Published: Feb. 1, 2025
Infertility
caused
by
endometriosis
(EM)
directly
affects
the
possibility
of
pregnancy
in
women
gestational
age.
This
study
aims
to
establish
a
prediction
model
accurately
predict
natural
outcome
patients
with
EM,
providing
valuable
information
for
clinical
decision-making.
We
retrospectively
selected
total
496
who
underwent
their
first
laparoscopic
surgery
infertility
at
Obstetrics
and
Gynecology
Department
Jingzhou
Central
Hospital
from
January
2016
June
2023.
An
improved
fertility
index
(EFI)
predictive
was
created
based
on
ultrasound
radiomics
urinary
proteomics
gathered
during
patient's
initial
admission,
using
two
machine
learning
algorithms.
The
evaluated
C-index,
calibration,
applicability
through
receiver
working
characteristic
curve,
decision
curve
analysis.
EFI
nomogram,
five
parameters
three
urine
proteomics,
had
AUC
values
0.921
(95%
CI:
0.864-0.978)
0.909
0.852-0.966)
training
validation
sets,
respectively,
while
traditional
0.889
0.832-0.946)
0.873
0.816-0.930)
respectively.
Additionally,
nomogram
exhibited
better
discrimination
ability
achieved
an
overall
benefit
against
threshold
probability
than
tree
analysis
(DCA).
combined
radiomics-urine
able
pregnancy-associated
EM
compared
classical
score.
can
help
clinicians
individual
risk
following
first-ever
facilitate
earlier
diagnosis
treatment.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(29)
Published: Oct. 14, 2024
Abstract
Precise
theranostics
of
tumors
is
intricately
linked
to
the
early
detection
and
monitoring
lymph
nodes
(LN)
metastases,
making
targeted
localization
LNs
essential
for
tumor
identification.
However,
designing
LN‐targeting
probes
remains
a
significant
challenge
due
issues
such
as
lymphatic
uptake,
biocompatibility,
fluorescence
stability.
To
address
these
challenges,
near‐infrared
II
(NIR‐II)
are
developed
through
meticulous
analysis
LN
physiological
structure
passive
targeting
strategy
therapy.
An
LPP‐QDs‐IR‐820
nanocomposite
(NCs)
engineered,
comprising
IR‐820
molecules
ultrabright
PbS@CdS
quantum
dots
(QDs),
which
encapsulated
within
liposome‐SH‐mPEG
2000
polymer
matrix.
These
NCs
demonstrates
remarkable
enrichment,
facilitating
real‐time
tracking
via
electrostatic
repulsion
extracellular
matrix
effects.
Importantly,
exhibit
negligible
in
vivo
toxicity
high
biocompatibility.
The
intense
NIR‐II
emissions
QDs
confer
upon
yield
(6%).
cervical
their
deep
microvessels
clearly
observed
imaging.
Moreover,
photothermal
properties
enable
achieve
conversion
efficiency
36.56%,
leading
effective
therapy
mice.
Annals of Medicine and Surgery,
Journal Year:
2023,
Volume and Issue:
86(2), P. 805 - 810
Published: Nov. 7, 2023
Due
to
the
information-rich
nature
of
positron
emission
tomography/computed
tomography
(PET/CT)
images,
authors
hope
explore
radiomics
features
that
could
distinguish
metastatic
lymph
nodes
(LNs)
from
hypermetabolic
benign
LNs,
in
addition
conventional
indicators.
Clinical and Experimental Obstetrics & Gynecology,
Journal Year:
2024,
Volume and Issue:
51(6), P. 145 - 145
Published: June 19, 2024
Objectives:
Until
2018,
cervical
cancer
(CC)
was
clinically
staged;
however,
it
frequently
under-staged.
For
this
reason,
in
the
International
Federation
of
Gynecology
and
Obstetrics
(FIGO)
incorporated
imaging
assessment
into
staging
malignancy.
The
aim
review
is
to
discuss
available
data
regarding
role
diagnosis,
pretreatment
staging,
how
an
adequate
radiological
evaluation
could
assist
treatment
planning
for
CC.
Mechanism:
An
extensive
literature
search
conducted
identify
relevant
studies
across
various
databases,
including
articles
addressing
topics
related
used
selected
underwent
thorough
examination
that
met
objectives
review,
taking
account
specified
inclusion
exclusion
criteria.
Subsequently,
were
extracted
analyzed
each
article.
Findings
Brief:
Transvaginal
ultrasound
(TVS)
transrectal
(TRUS)
have
been
shown
be
accurate
diagnostic
tools
assessing
local
spread
CC
disease.
Currently,
magnetic
resonance
(MRI)
appears
offer
highest
sensitivity,
specificity,
accuracy
detecting
parametrial
stromal
invasion,
as
well
tumor
size.
Computed
tomography
(CT)
contrast-enhanced
(CE)-CT
are
considered
best
modalities
detection
lymph
node
metastases.
However,
positron
emission
(PET)
has
demonstrated
notable
precision
exhibited
high
negative
predictive
value
predicting
pelvic
nodal
status
during
early-stage
diagnosis
diagnosis.
Radiomics
represents
a
newly
introduced
field
translational
research
with
potential
predict
several
pathological
variables
carcinoma
patients.
These
include
disease
histological
type,
status,
probability
recurrence,
estimated
survival.
Conclusions:
Imaging
plays
indispensable
monitoring
evolution
pathology
response
therapies
over
time.
It
provides
physicians
tool
optimal
regulation
therapeutic
strategy.
