Association between C-reactive protein to albumin ratio and subclinical myocardial injury in the general population free from cardiovascular disease DOI Creative Commons

Shuiying Li,

Yichen Wang, Na Xu

et al.

Journal of Cardiothoracic Surgery, Journal Year: 2024, Volume and Issue: 19(1)

Published: Aug. 23, 2024

The study aimed to examine the role of C-reactive protein albumin ratio (CAR) as an inflammatory biomarker in relation subclinical myocardial injury (SC-MI), addressing limited knowledge their association. included 5,949 individuals without cardiovascular disease (CVD) from National Health and Nutrition Examination Survey. SC-MI was identified through a Cardiac Infarction Injury Score (CIIS) ≥ 10 units based on 12-lead electrocardiogram. used multivariate logistic regression models, adjusted for potential confounders, evaluate relationship between CAR SC-MI. Subgroup analyses were conducted substantiate results, non-linear correlation assessed via restricted cubic spline (RCS) regression. RCS curve showed significant positive (P nonlinear = 0.2496). When all highest tertile exhibited higher likelihood compared those lowest tertile, with odds (OR) 1.21 (95% CI: 1.06–1.39, P trend 0.029). A 10-unit increment linked 3.6% heightened risk [OR 1.036 1.006, 1.066)], this association being more prominent among male adults, non-smokers, married individuals, diabetes mellitus, no history cancer. findings suggest US adult population, indicating enhancing prevention strategies general population.

Language: Английский

An inverted U-shaped association between high-sensitivity C-reactive protein and the albumin ratio and hepatic steatosis and liver fibrosis: a population-based study DOI Creative Commons

Xiaorong Ma,

Baoyu Li,

Yuwei Liu

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: April 15, 2025

Background The high-sensitivity C-reactive protein to albumin (CAR) ratio is a comprehensive measure of inflammation in vivo . Hepatic steatosis and fibrosis are significantly correlated with inflammation. present study aimed explore the possible associations between CAR hepatic American population. Methods population involved National Health Nutrition Examination Survey (NHANES) participants from 2017 2020. natural logarithm CAR, calculated as Ln(CAR) base “e,” was used for further analyses. relationships controlled attenuation parameter (CAP) liver stiffness measurement (LSM) were investigated through multivariate linear regression analysis. Interaction subgroup analysis identified factors affecting these variables. Nonlinear elucidated by smoothing curves threshold effect Receiver operating characteristic (ROC) curve performed evaluate predictive performance non-alcoholic fatty disease (NAFLD). results adjusted U.S. estimates. Results included total 7,404 individuals. positively CAP fully model, an value β = 1.827 (95% CI, 0.611, 3.042). A more pronounced positive association observed among BMI ≥ 25 kg/m 2 An inverted U-shaped shown smooth fitting two-segment inflection point (−9.594). ROC showed that had moderate NAFLD (AUC 0.6895), sensitivity 0.7276 specificity 0.6092. No significant detected LSM. Conclusion We demonstrate relationship risk within demographic. Our suggest may serve valuable diagnostic tool NAFLD. Further prospective research necessary validate this conclusion.

Language: Английский

Citations

0
Association of high-sensitivity C-reactive protein to albumin ratio with all-cause and cardiac death in coronary heart disease individuals: A retrospective NHANES study DOI Creative Commons
Shangxun Zhou,

Miaohan Qiu,

Kexin Wang

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(5), P. e0322281 - e0322281

Published: May 28, 2025

Background This research aimed to explore the association of high-sensitivity C-reactive protein albumin ratio (CAR) with death events in community-based patients coronary heart disease (CHD). Methods 624 CHD participants were followed for 36 months using data from 2015–2018 National Health and Nutrition Examination Survey (NHANES). The CAR was dichotomized at 0.075 mg/g stratify inflammation levels. Relationships between CAR, (hsCRP), (ALB) all-cause cardiac all subgroups analyzed restricted cubic spline (RCS), Kaplan-Meier survival curves Cox proportional hazards models. Results Both hsCRP showed positive correlations risk while ALB exhibited a U-shaped correlation but negative risk. high-CAR group had higher risks (P = 0.04) 0.02). hazard ratios (HR) (95% confidence intervals (CI)) 1.77 (1.15–2.74) 0.010), it 2.99 (1.44–6.22) 0.003) death. No significant interaction observed subgroup analyses. Conclusions A threshold effectively distinguished high low risks. Elevated significantly increased community patients.

Language: Английский

Citations

0
Association between C-reactive protein/albumin ratio and all-cause mortality in patients with stroke: Evidence from NHANES cohort study DOI

Jinguo Yuan,

Yawen Cheng,

Xiangning Han

et al.

Nutrition Metabolism and Cardiovascular Diseases, Journal Year: 2024, Volume and Issue: 34(10), P. 2305 - 2314

Published: May 31, 2024

Language: Английский

Citations

2
The value of systemic immune inflammation index, white blood cell to platelet ratio, and homocysteine in predicting the instability of small saccular intracranial aneurysms DOI Creative Commons
Wanwan Zhang, Chao Xiang, Boliang Liu

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 16, 2024

Inflammation has a destructive effect on the homeostasis of vascular wall, which is involved in formation, growth, and rupture human intracranial aneurysms (IAs) disease progression. However, inflammation-related markers have not been well studied risk stratification unruptured IAs. The purpose this study was to investigate predictive value serum inflammatory unstable progression small saccular (SIAs). This retrospectively included 275 patients with SIAs (aneurysm diameter less than or equal 7 mm), compare level difference complex marker systemic immune-inflammatory index (SII), white blood cell platelet ratio (WPR), homocysteine (Hcy) stable (asymptomatic unruptured) (symptomatic unruptured, ruptured) SIAs. 187 (68%) had aneurysm-related compression symptoms outcomes. In multivariate logistic regression after adjusting for baseline differences, SII, WPR, Hcy were independent factors instability SIAs, prediction model combined other (previous stroke history, aneurysm irregularity) showed good ability an area under curve 0.905. addition, correlation analysis that also significant differences symptomatic ruptured higher inflammation levels often promoted Higher WPR can be used as predictors As economical convenient biomarker, it crucial clinical treatment strategies

Language: Английский

Citations

2
CAR, mGPS and hs-mGPS: What is among them the best gero-biomarker for age-related diseases? And for what clinical application? DOI

Miriam Carella,

Daniele Magro,

Letizia Scola

et al.

Mechanisms of Ageing and Development, Journal Year: 2024, Volume and Issue: 220, P. 111952 - 111952

Published: June 4, 2024

Language: Английский

Citations

0
Association between C-reactive protein to albumin ratio and subclinical myocardial injury in the general population free from cardiovascular disease DOI Creative Commons

Shuiying Li,

Yichen Wang, Na Xu

et al.

Journal of Cardiothoracic Surgery, Journal Year: 2024, Volume and Issue: 19(1)

Published: Aug. 23, 2024

The study aimed to examine the role of C-reactive protein albumin ratio (CAR) as an inflammatory biomarker in relation subclinical myocardial injury (SC-MI), addressing limited knowledge their association. included 5,949 individuals without cardiovascular disease (CVD) from National Health and Nutrition Examination Survey. SC-MI was identified through a Cardiac Infarction Injury Score (CIIS) ≥ 10 units based on 12-lead electrocardiogram. used multivariate logistic regression models, adjusted for potential confounders, evaluate relationship between CAR SC-MI. Subgroup analyses were conducted substantiate results, non-linear correlation assessed via restricted cubic spline (RCS) regression. RCS curve showed significant positive (P nonlinear = 0.2496). When all highest tertile exhibited higher likelihood compared those lowest tertile, with odds (OR) 1.21 (95% CI: 1.06–1.39, P trend 0.029). A 10-unit increment linked 3.6% heightened risk [OR 1.036 1.006, 1.066)], this association being more prominent among male adults, non-smokers, married individuals, diabetes mellitus, no history cancer. findings suggest US adult population, indicating enhancing prevention strategies general population.

Language: Английский

Citations

0