Complex neural-immune interactions shape glioma immunotherapy DOI Creative Commons
Kun-Wei Song, Michael Lim, Michelle Monje

et al.

Immunity, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

Mapping Knowledge Structure and Themes Trends of Ewing Sarcoma: A Text-Mining Study DOI
Haiyang Wu,

Zaijie Sun,

Zeng GuiPing

et al.

Annals of Surgical Oncology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Language: Английский

Citations

1
Tumor-Associated Extracellular Matrix Obstacles for CAR-T Cell Therapy: Approaches to Overcoming DOI Creative Commons
Ilya Klabukov, Alexander E. Kabakov, A. O. Yakimova

et al.

Current Oncology, Journal Year: 2025, Volume and Issue: 32(2), P. 79 - 79

Published: Jan. 30, 2025

Chimeric antigen receptor (CAR)-T cell therapy yields good results in the treatment of various hematologic malignancies. However, efficacy CAR-T against solid tumors has proven to be limited, primarily because tumor-associated extracellular matrix (ECM) creates an intractable barrier for cytotoxic cells that are supposed kill cancer cells. This review unravels multifaceted role ECM impeding infiltration, survival, and functions within tumors. We analyze situations when intratumoral limits by being a purely physical complicates lymphocyte penetration/migration also acts as immunosuppressive factor impairs antitumor activities In addition, we highlight promising approaches such engineering with improved capabilities penetrate migrate into/through ECM, combination therapies aimed at attenuating high density potential others enable overcoming ECM-related obstacles. A detailed overview data relevant studies not only helps better understand interactions between but outlines ways more effectively use

Language: Английский

Citations

0
The role of tenascin-C in tumor microenvironments and its potential as a therapeutic target DOI Creative Commons
Yaran Wang,

Xiaohui Wen,

Chao Su

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 19, 2025

The tumor microenvironment (TME) plays a pivotal role in cancer development and progression, comprises various cellular non-cellular components that interact with cells. Tenascin-C (TNC) is an extracellular matrix glycoprotein widely expressed the stroma influences critical processes, such as cell adhesion, migration, immune modulation. This review examines multifaceted roles of TNC different TMEs, including mechanical, immune, metabolic microenvironments, well radiation (RME). In context mechanical microenvironment, actively participates remodeling, thereby facilitating invasion. Notably, exhibits immunosuppressive effects on T cells promotes recruitment within microenvironment. Furthermore, implicated hypoxia response, glucose metabolism reprogramming, regulation pH balance, underscoring its Intriguingly, also radiosensitivity RME. explores potential biomarker for prognosis target therapeutic interventions. By integrating recent advances single-cell sequencing spatial omics, we propose innovative strategies leveraging personalized therapy. Future research directions are discussed, focusing distinct isoforms TNC, their interaction networks, radiotherapy efficacy. comprehensive analysis underscores importance understanding dynamics improving treatment outcomes.

Language: Английский

Citations

0
Complex neural-immune interactions shape glioma immunotherapy DOI Creative Commons
Kun-Wei Song, Michael Lim, Michelle Monje

et al.

Immunity, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

Citations

0