Causal associations between 26 musculoskeletal disorders and gut microbiota: A Mendelian randomization analysis with Bayesian validation DOI Creative Commons
Yunhao Wang, Yuanyuan Sun, Hsiu‐Jung Liao

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 22, 2024

Abstract Emerging evidence suggests that gut microbiota imbalances may influence the onset of musculoskeletal disorders (MSDs), yet conclusive establishing causation remains limited. This study investigates causal relationship between and a range MSDs, aiming to identify potential therapeutic targets. Using data on 211 microbiome taxa from genome-wide association (GWAS) summary statistics for 26 MSDs Finnish Biobank, we employed Mendelian randomization (MR) with inverse-variance weighting (IVW) as primary analytical approach, complemented by Bayesian model validation ensure robust results. Our MR analyses revealed significant associations nine within four categories, including osteoporosis (IVW-Beta = 0.011, P 0.025), rheumatoid arthritis -0.016, < 0.001), rotator cuff syndrome -0.007, 0.022), calcific tendonitis shoulder -0.021, 0.034). underscored plausibility these relationships, supporting role in development disorders. findings present library underscore microbiome's MSD pathogenesis, providing genetic highlights specific prospective research offers novel insights into pathogenic mechanisms underlying points toward new directions future investigation microbiome-based therapies.

Language: Английский

Causal associations between 26 musculoskeletal disorders and gut microbiota: a Mendelian randomization analysis with Bayesian validation DOI Creative Commons
Yunhao Wang, Yuanyuan Sun, Hsiu‐Jung Liao

et al.

World Journal of Microbiology and Biotechnology, Journal Year: 2025, Volume and Issue: 41(3)

Published: March 1, 2025

Language: Английский

Citations

1
Gut microbiota and psoriasis: pathogenesis, targeted therapy, and future directions DOI Creative Commons
Xinyan Zou,

Xinfu Zou,

Longxia Gao

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Aug. 7, 2024

Psoriasis is one of the most common autoimmune skin diseases. Increasing evidence shows that alterations in diversity and function microbiota can participate pathogenesis psoriasis through various pathways mechanisms.

Language: Английский

Citations

5
Fecal microbiota transplantation in autoimmune diseases – An extensive paper on a pathogenetic therapy DOI

Isa Seida,

Maisam Al Shawaf,

Naim Mahroum

et al.

Autoimmunity Reviews, Journal Year: 2024, Volume and Issue: 23(7-8), P. 103541 - 103541

Published: April 7, 2024

Language: Английский

Citations

4
The gut microbiota in spondyloarthritis: an update DOI
Valeria Ríos Rodríguez, Morgan Essex, Denis Poddubnyy

et al.

Current Opinion in Rheumatology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Purpose of review This provides an updated overview the gut microbiota's involvement in spondyloarthritis (SpA) from a clinical perspective. It explores mechanisms by which microbiota may influence SpA pathogenesis and considers therapeutic implications targeting microbiome treatment. Recent findings The is multifactorial, involving genetic predisposition, external factors dysregulation immune system. studies have identified alterations patients with SpA, including changes microbial diversity specific taxa linked to disease activity. HLA-B27 status seems composition, potentially impacting progression. In transgenic rats, association between development has been confirmed, supporting human studies. A compromised barrier, influenced proteins like zonulin, allow antigens translocate, triggering responses associated SpA. Summary These highlight potential for microbiota-modulating therapies, such as probiotics, prebiotics, diet exercise, managing However, methodological variability exposes need more rigorous research better understand these associations. offer opportunity refine treatment strategies, offering personalized approach disease.

Language: Английский

Citations

0
Fecal microbiota transplantation-current perspective on human health DOI Creative Commons

Zixuan Cao,

Tingting Gao, Ousman Bajinka

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: March 14, 2025

Recently, microbiome medicine has attracted the attention of researchers. While this rapidly growing medical approach for various diseases and disorders is changing paradigm, it imperative to weigh both its benefits associated risk factors. For instance, manipulation gut microbiota (GM) positive effects on metabolic neurodegenerative diseases. Notably, fecal transplantation (FMT), a complex method, shown promise; however, many doubt feasibility without adverse human health. Given number clinical trials investigating FMT treatment disorders, review summarizes recent findings impact This responses with their reversal gastrointestinal infections, behavioral changes, immune responses. Additionally, discusses role in antimicrobial resistance co-supplementation health, safety, potential risks, limitations, prospects, recommendations. Although does not cover all studies database, searched terms health are sufficient provide summary current perspective.

Language: Английский

Citations

0
New horizons in the treatment of psoriasis: modulation of gut microbiome DOI Creative Commons
Mojtaba Memariani, Hamed Memariani

Heliyon, Journal Year: 2025, Volume and Issue: 11(1), P. e41672 - e41672

Published: Jan. 1, 2025

The last decennia have witnessed spectacular advances in our knowledge about the influence of gut microbiome on development a wide swathe diseases that extend beyond digestive tract, including skin like psoriasis, atopic dermatitis, acne vulgaris, rosacea, alopecia areata, and hidradenitis suppurativa. novel concept gut-skin axis delves into how interact through inflammatory mediators, metabolites, intestinal barrier. Elucidating effects health could provide new opportunities for developing innovative treatments dermatological diseases. Psoriasis is complex disease with multiple factors contributing to its development, such as diet, lifestyle, genetic predisposition, microbiome. This paper has dual purpose. First, we outline current unique microbiota patterns implicated pathogenesis psoriasis. Second, equal importance, briefly discuss reciprocal impact psoriasis treatment In addition, this review explores potential therapeutic targets based microbial interventions, which hold promise providing options

Language: Английский

Citations

0
Shared Pathophysiology of Inflammatory Bowel Disease and Psoriasis: Unraveling the Connection DOI Open Access

Walter Jauregui,

Yozahandy A Abarca,

Yasmin Ahmadi

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 3, 2024

Psoriasis (PS) and inflammatory bowel disease (IBD) are immune-mediated chronic conditions that share pathophysiological processes, including immune system dysfunction, microbiome dysbiosis, pathways. These pathways result in increased turnover of epithelial cells compromised barrier function. The assessment the literature suggests immunopathogenic mechanisms, such as tumor necrosis factor (TNF)-α signaling IL-23/IL-17 axis dysregulation, shared by PS IBD. Clinical characteristics diagnostic approaches overlap significantly, advances biomarker identification benefit both conditions. Current treatments, namely biologics target TNF-α, IL-17, IL-23, show promising results decreasing inflammation controlling symptoms. Precision medicine prioritized prospective therapeutic procedures to tailor pharmaceuticals based on specific biomarkers, perhaps improving outcomes minimizing side effects. This study thoroughly examines evaluates body research Several papers were examined compile data clinical features, diagnosis, therapies, pathophysiology, epidemiology, potential future developments. selection articles was three methodological qualities: relevance addition knowledge IBD PS. retrieved combined provide a coherent summary state spot new trends. overview latest studies demonstrates foundations approaches. With spotlight particular precision path toward enhancing effectiveness

Language: Английский

Citations

2
Fecal microbiota transplantation for the treatment of intestinal and extra‐intestinal diseases: Mechanism basis, clinical application, and potential prospect DOI Creative Commons

Dongxin Yi,

Tao Li,

Yuji Xiao

et al.

Bioengineering & Translational Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 7, 2024

To review the theoretical basis and therapeutic effects of fecal microbiota transplantation (FMT) in various diseases animal experiments clinical studies, as well limitations current standards FMT application. PubMed Web Science databases were searched for articles published only English between 1975 2023 on reliable results treatment FMT. The properties gut its interactions with host metabolism are critical to human health, microbiome disturbance is closely associated intestinal extra-intestinal diseases. Therefore, tools targeting modulation have attracted increasing attention, among which represents most widely studied intervention strategy. This gathered summarized application diseases, metabolic hypertension, cancer, nervous system arthritis, elaborated beneficial that can be achieved by altering mechanisms action. In addition, potential risks side approach discussed, efforts standardize development Through a systemic outcome mechanism we aimed provide construction an optimized framework, so better exert prospects.

Language: Английский

Citations

0
Causal associations between 26 musculoskeletal disorders and gut microbiota: A Mendelian randomization analysis with Bayesian validation DOI Creative Commons
Yunhao Wang, Yuanyuan Sun, Hsiu‐Jung Liao

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 22, 2024

Abstract Emerging evidence suggests that gut microbiota imbalances may influence the onset of musculoskeletal disorders (MSDs), yet conclusive establishing causation remains limited. This study investigates causal relationship between and a range MSDs, aiming to identify potential therapeutic targets. Using data on 211 microbiome taxa from genome-wide association (GWAS) summary statistics for 26 MSDs Finnish Biobank, we employed Mendelian randomization (MR) with inverse-variance weighting (IVW) as primary analytical approach, complemented by Bayesian model validation ensure robust results. Our MR analyses revealed significant associations nine within four categories, including osteoporosis (IVW-Beta = 0.011, P 0.025), rheumatoid arthritis -0.016, < 0.001), rotator cuff syndrome -0.007, 0.022), calcific tendonitis shoulder -0.021, 0.034). underscored plausibility these relationships, supporting role in development disorders. findings present library underscore microbiome's MSD pathogenesis, providing genetic highlights specific prospective research offers novel insights into pathogenic mechanisms underlying points toward new directions future investigation microbiome-based therapies.

Language: Английский

Citations

0