Evaluating the causal effect of using glucagon-like peptide-1 receptor agonists on the risk of autoimmune diseases

Diabetes & Metabolic Syndrome Clinical Research & Reviews, Journal Year: 2025, Volume and Issue: 19(1), P. 103186 - 103186

Published: Jan. 1, 2025

Language: Английский

---

Obesity and Chronic Inflammation: Implications for Rheumatoid Arthritis, Spondyloarthritis, and Ulcerative Colitis

Immunity Inflammation and Disease, Journal Year: 2025, Volume and Issue: 13(1)

Published: Jan. 1, 2025

Immune-mediated inflammatory diseases (IMIDs) are a group of chronic conditions characterized by dysregulated immune responses and persistent inflammation. Rheumatoid arthritis (RA), spondyloarthritis (SpA), ulcerative colitis (UC) exemplify prominent IMIDs, each presenting unique challenges for their management, that impact patient's quality life (QoL). Obesity, marked low-grade inflammation, influences the progression, response to treatment, clinical management patients with RA, SpA, UC. Besides, emerging role sarcopenic obesity, special subtype obesity malnutrition, should be considered in definition appropriated therapeutic interventions.

Language: Английский

---

Association between body roundness index and osteoarthritis/rheumatoid arthritis: a cross-sectional study

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 20, 2025

To explore the relationship between Body Roundness Index (BRI) and prevalence of osteoarthritis (OA) rheumatoid arthritis (RA) among American adults, providing new insights for identifying OA RA in adults. We analyzed data from National Health Nutrition Examination Survey (NHANES) 2015–2023 conducted a large cross-sectional study. BRI was calculated based on body measurements, while cases were identified through questionnaires. Participants under 20 years age those with incomplete excluded. Weighted multivariate logistic regression models, restricted cubic spline (RCS) functions, stratified analyses used to assess levels further evaluate BRI's diagnostic potential RA, receiver operating characteristic (ROC) curves employed analyze calculate area curve (AUC). After screening, 17,544 participants included, 2,382 (13.58%) 987 (5.63%). Multivariate showed positive correlation adults both unadjusted adjusted models. A similar observed partially models (P < 0.001), but fully model no significant association > 0.05). In model, highest quartile 3.47 times than that lowest (95% CI: 2.84, 4.24, P 0.001). Even remained 1.46 higher 1.02, 2.08, RCS demonstrated non-linear increase as rose Subgroup forest plots indicated most subgroups ROC had better predictive ability risk compared BMI. There is especially OA. Maintaining lower may help prevent onset RA.

Language: Английский

---

Beneficial Effects of Omega-3 Fatty Acids on Obesity and Related Metabolic and Chronic Inflammatory Diseases

Nutrients, Journal Year: 2025, Volume and Issue: 17(7), P. 1253 - 1253

Published: April 3, 2025

Omega-3 polyunsaturated fatty acids (n-3 PUFAs) are known to help resolve inflammation through generation of anti-inflammatory eicosanoids and specialized pro-resolving mediators, including resolvins, protectins, maresins. Through binding the GPR120/FFAR4 receptor, their beneficial effects result from phospholipid membrane remodeling, impairment inflammatory signaling molecules clustering, subsequent inhibition NF-κB inflammasome activation, a reduction in oxidative stress. Obesity, chronic disease that contributes metabolic disorders, is alleviated by n-3 PUFAs. In adipose tissue (AT) individuals with obesity, PUFAs counteract hypoxia, inhibit immune cell infiltration AT inflammation, improve insulin sensitivity, reduce fat mass. Beyond AT, also alleviate other disorders such as metabolic-associated steatotic liver (MASLD), gut dysbiosis, and/or renal dysfunction. cardiovascular (CVD), they mainly recommended secondary prevention for patients coronary heart risks. This review provides an in-depth analysis benefits obesity related diseases, examining both mechanistic clinical aspects. Additionally, it explores obesity-related conditions, bowel disease, psoriasis, rheumatoid arthritis, osteoarthritis, multiple sclerosis, targeting specific pathophysiological mechanisms. Clinical applications limitations discussed based on findings human trials.

Language: Английский

---

In early rheumatoid arthritis, comorbidities do not explain the increased risk of failure to reach remission in patients with obesity

RMD Open, Journal Year: 2025, Volume and Issue: 11(2), P. e005430 - e005430

Published: April 1, 2025

Objective To examine whether obesity and/or overweight are independently associated with an increased risk of remission failure in patients early rheumatoid arthritis (RA), treated methotrexate as first disease-modifying antirheumatic drug, or if the previously reported associations could be explained by underlying comorbidities and lifestyle factors. Methods For included Epidemiological Investigation Rheumatoid Arthritis (EIRA) study 2006–2018 initiating monotherapy (n=1285), we captured data on body mass index, disease activity from EIRA through linkage to nationwide Swedish clinical quality registers. The primary outcome was reach 28-joint Disease Activity Score (DAS28) at 3 6 months. Secondary outcomes Boolean, Simplified Index Clinical their individual components. We estimated relative (RR) compared normal weight using modified Poisson regression, adjusting for potential confounders. Results After months, 64% (n=98/153) obesity, 52% (n=171/326) 48% (n=210/433) failed DAS28 remission, RR 1.33 (95% CI 1.14 1.55) after adjustment age sex. remained further seropositivity, educational level, smoking, alcohol use, physical activity, calendar period, glucocorticoid treatment (RR=1.27, 95% 1.08 1.50). No significant association observed overweight. results were similar secondary Conclusion Obesity is a factor RA, independent comorbid conditions.

Language: Английский

---

The C-reactive protein (CRP)-albumin-lymphocyte (CALLY) index exhibits an L-shaped association with all-cause mortality in rheumatoid arthritis patients: a retrospective cohort study

BMC Rheumatology, Journal Year: 2025, Volume and Issue: 9(1)

Published: April 22, 2025

Language: Английский

---