Published: Jan. 1, 2023
The research aimed to create a groundbreaking neuromodulation method improve consciousness. Firstly, an innovative rhythmic sound and electric stimulation technique was introduced modulate consciousness in healthy individuals. Subsequently, this tested on patients with disorders. study concluded by examining the impact of brain connectivity, shedding light fundamental mechanism technique.
Language: Английский
Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)
Published: Nov. 9, 2023
Disorders of consciousness (DoC), namely unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS), represent severe conditions with significant consequences for patients their families. Several studies have reported the regaining in such using deep brain stimulation (DBS) subcortical structures or brainstem nuclei. Our study aims to present 10 years' experience a single center DBS as therapy on cohort DoC. Eighty Three consecutive were evaluated between 2011 2022; entry criteria consisted neurophysiological neurological evaluations neuroimaging examinations. Out 83, 36 considered candidates implantation, 32 implanted: 27 had UWS, five MCS. The target was centromedian-parafascicular complex left hemisphere hypoxic lesion one better preserved traumatic injury. level improved seven patients. out MCS emerged full awareness, ability interact communicate. Two them can live largely independently. Four UWS showed improvement two emerging other reaching In DoC lasting longer than 12 months following injury 6 anoxic-ischemic lesion, spontaneous recovery is rare. Thus, certain thalamic nuclei could be recommended treatment option who meet neurological, criteria, especially earlier phases, before occurrence irreversible musculoskeletal changes. Furthermore, we emphasize importance cooperation centers worldwide potentials treating
Language: Английский
Citations
13
BMEMat, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 12, 2025
Abstract Brain‐computer interface (BCI) is an advanced technology that establishes a direct connection between the brain and external devices, enabling high‐speed real‐time information exchange. In BCI systems, electrodes are key devices responsible for transmitting signals including recording electrophysiological electrically stimulating nerves. Early were mainly composed of rigid materials. The mismatch in Young's modulus soft biological tissue can lead to rejection reactions within system, resulting electrode failure. Furthermore, prone damaging tissues during implantation use. Recently, flexible have garnered attention field science research due their better adaptability softness curvature brain. design effectively reduce mechanical damage neural improve accuracy stability signal transmission, providing new tools methods exploring function mechanisms developing novel technologies. Here, we review advancements systems. This paper emphasizes importance discusses limitations traditional electrodes, introduces various types detail. addition, also explore practical application scenarios future development trends technology, aiming offer valuable insights enhancing performance user experience
Language: Английский
Citations
0
Journal of Neurorestoratology, Journal Year: 2025, Volume and Issue: unknown, P. 100191 - 100191
Published: Feb. 1, 2025
Language: Английский
Citations
0
CNS Neuroscience & Therapeutics, Journal Year: 2025, Volume and Issue: 31(3)
Published: March 1, 2025
The heart rate variability (HRV) of patients with disorders consciousness (DOC) differs from healthy individuals. However, there is rarely research on HRV among DOC following treatment deep brain stimulation (DBS). This study aims to investigate the modulatory effects DBS-on central-autonomic nervous system based variations. We conducted DBS surgery eight DOC. Postoperatively, all underwent short-duration for 3 days, frequencies 25 Hz, 50 and 100 Hz respectively. Each day comprised four cycles, a duration 30 min 90 DBS-off. obtained coma recovery scale-revised (CRS-R) scores synchronously recorded electrocardiographic data. analyzed indices, including time-domain frequency-domain parameters across various time points patients. exhibited consistent trend three groups different parameters. Notably, most pronounced changes were induced by Hz. Long-term follow-up indicates that high-frequency (HF), low-frequency (LF), total power (TP) may serve as predictive indicators in prognosis Our reveals enhances patient while increasing HRV. Specifically, indices correlate favorable prognosis.
Language: Английский
Citations
0
CNS Neuroscience & Therapeutics, Journal Year: 2023, Volume and Issue: 30(6)
Published: Dec. 19, 2023
Abstract Background The management of patients with disorders consciousness (DOC) presents substantial challenges in clinical practice. Deep brain stimulation (DBS) has emerged as a potential therapeutic approach, but the lack standardized regulatory parameters for DBS DOC hinders definitive conclusions. Objective This comprehensive review aims to provide detailed summary current issues concerning patient selection, target setting, and modulation studies investigating application patients. Methods A meticulous systematic analysis literatures was conducted, encompassing articles published from 1968 April 2023, retrieved reputable databases (PubMed, Embase, Medline, Web Science). Results 21 eligible articles, involving 146 resulting acquired injury or other disorders, revealed significant insights. most frequently targeted regions were Centromedian‐parafascicular complex (CM‐pf) nuclei central thalamus (CT), both recognized their role regulating consciousness. However, targets have also been explored different studies. frequency predominantly set at 25 100 Hz, pulse width 120 μs, voltages ranged 0 4 V. These customized based on individual responses evaluations. overall efficacy rate all included 39.7%, indicating positive effect subset Nonetheless, assessment methods, follow‐up durations, outcome measures varied across studies, potentially contributing variability reported rates. Conclusion Despite arising parameters, shows promising option DOC. there still remains need protocols which are crucial deepen understanding optimizing this specific population.
Language: Английский
Citations
10
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown
Published: April 19, 2025
Loss of consciousness under anaesthesia is accompanied by widespread silencing neurons, and disruption cortical dynamics. Yet, how this affects mesoscale signal propagation within higher-order associative areas, crucially implicated in theories consciousness, remains poorly understood. Here we combined intracortical microstimulation, simultaneous multielectrode recordings the ventrolateral prefrontal cortex (vlPFC) posterior parietal (PPC) macaques across wakefulness, graded depths anaesthesia. Spiking responses revealed distinct regimes: PFC, higher-amplitude stimulation elicited a delayed single rebound after sustained inhibition, whereas PPC, faster double-rebound profile emerged. Despite enhanced local spiking LFP responsivity anaesthesia, found strong selective suppression lateral PFC - breakdown strikingly absent PPC. This dissociation suggests that disrupts not merely populations, but impairing integrative processes critical for neuronal dynamics at multiple scales. Our findings demonstrate casual spatially-resolved manner, spread key mechanism underlying conscious awareness its loss
Language: Английский
Citations
0
Neurosurgical Review, Journal Year: 2023, Volume and Issue: 46(1)
Published: Aug. 14, 2023
Language: Английский
Citations
8
IEEE Transactions on Neural Systems and Rehabilitation Engineering, Journal Year: 2024, Volume and Issue: 32, P. 923 - 933
Published: Jan. 1, 2024
Deep brain stimulation (DBS) is establishing itself as a promising treatment for disorders of consciousness (DOC). Measuring changes crucial in the optimization DBS therapy DOC patients. However, conventional measures use subjective metrics that limit investigations treatment-induced neural improvements. The focus this study to analyze regulatory effects and explain mechanism at functional level Specifically, paper proposed dynamic temporal-spectral analysis method quantify DBS-induced variations Functional near-infrared spectroscopy (fNIRS) promised evaluate levels was used monitor fNIRS-based experimental procedure with auditory stimuli developed, activities during from thirteen patients before after were recorded. Then, networks formulated sliding-window correlation phase lag index. Afterwards, respect temporal global regional networks, variability efficiency, local clustering coefficient extracted. Further, converted into spectral representations by graph Fourier transform, energy diversity assess variability. results showed under exhibited increased significantly associated Moreover, right regions had stronger enhancements than left regions. Therefore, well signifies patients, may serve biomarkers evaluations
Language: Английский
Citations
2
Brain stimulation, Journal Year: 2023, Volume and Issue: 16(5), P. 1522 - 1532
Published: Sept. 1, 2023
Deep brain stimulation (DBS) in the centromedian-parafascicular complex (CM-pf) has been reported as a potential therapeutic option for disorders of consciousness (DoC). However, lack understanding its electrophysiological characteristics limits improvement effect.To investigate CM-pf underlying (DoC) and recovery.We collected signals from 23 DoC patients who underwent central thalamus DBS (CT-DBS) surgery. Five typical features were extracted, including neuronal firing properties, multiunit activity (MUA) signal stability, spike-MUA synchronization strength (syncMUA), background noise level. Their correlations with level, outcome, primary clinical factors analyzed.11 out (0/2 chronic coma, 5/13 unresponsive wakefulness syndrome/vegetative state (UWS/VS), 6/8 minimally conscious minus (MCS-)) exhibited an level after CT-DBS. In CM-pf, significantly stronger gamma band syncMUA alpha normalized MUA power found MCS- patients. addition, higher rates, high-gamma power, more stable theta oscillation correlated better outcomes. Besides, we also identified properties that are factors, etiologies, age, duration DoC.We provide comprehensive analyses Our results support 'mesocircuit' hypothesis, one proposed mechanism recovery, reveal crucial pathogenesis DoC, predicting explaining effect on DoC.
Language: Английский
Citations
6
International Journal of Clinical and Health Psychology, Journal Year: 2024, Volume and Issue: 24(4), P. 100528 - 100528
Published: Oct. 1, 2024
Language: Английский
Citations
1